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陈克平(博导)

图片1.jpg

个人简介

姓名

陈克平

性别

出生日期

1960.9

职称

研究员

电话

0511-88791923

传真

0511-88791923

E-mail

【学术简介】

学习经历:

1997年9 月-2000年6 月,西南大学,特种经济动物饲养,博士学位。

1979年 9月-1983年6 月,安徽农业大学,蚕学专业,学士学位。

【教学及研究经历】

2001/1 -至今,江苏大学,生命科学研究院,研究员

2004/1 - 2004/8,日本东京大学,农学部,高访学者

1983/6 - 2000/12,中国农业科学院蚕业研究所,家蚕品种与育种研究室,副研究员

【学术社会兼职及荣誉】

1. 国家自然科学基金评委 2. 国际合作专家评委 3. 国际多种杂志评审 4. 国内多种杂志评审

【主讲课程】

博士研究生:

高级分子遗传学、蛋白质组学

硕士研究生:

分子遗传学

【指导硕、博士生研究方向】

博士研究生:

1. 转基因生物安全性评估 2. 病毒与宿主的相互博弈 3.蛋白质组及功能解析

硕士研究生:

1. 转基因生物安全性评估 2. 病毒与宿主的相互博弈 3.蛋白质组及功能解析

【研究领域】

蛋白质组,转基因对食品及环境安全性

【获奖情况】

(1) 家蚕二分浓核病毒和杆状病毒基因功能解析,姚勤,陈克平,李国辉,胡朝阳,刘晓勇,郭忠建,陈慧卿,申红星,周阳,奖励名称等级:江苏省科学技术进步二等奖。2013年。

(2) 家蚕两种主要病毒及与宿主相互作用的分子基础,荣获2013年教育部自然科学进步二等奖,主要完成人:姚勤,陈克平,胡朝阳,李国辉,刘晓勇,周阳,申红星。2013年。

出版专著

《模式生物家蚕》主编:陈克平、黄君霆、姚勤

主持或参加科研项目及人才计划项目情况

1. 国家自然科学基金面上项目、31572467、家蚕对重大病毒病(BmNPV)抗性基因定位及鉴定、2016/1-2019/12、79万、主持。

2. 国家重点基础研究发展计划(973)、2012CB114604、家蚕的免疫应答与抗性机制、2012/1-2016/8、80万、在研、参加单位主持。

3. 国家转基因重大专项、2009ZX08012018B、高通量二维电泳-质谱联动技术检测转基因水稻产品、2009/6-2011/12、221万、已结题、主持。

4. 国家转基因重大专项、2008ZX08011-001、转基因水稻环境安全评价技术、2008/7-2011/4、64万、已结题、主持。

5. 江苏省农业支撑项目、BE2008379、家蚕优质高产兼抗两种病毒病育种及应用、2008/6-2011/6、结题、主持。

6. “六大人才高峰”培养对象,2007年,生命科学。

7. 国家"973"、2005CB121006、家蚕小分子mRNA、小肽功能以及病原体与宿主相互作用机理研究、2006-2010、60万、结题、参加单位主持。

8. 国家自然科学基金(面上)、30370773、家蚕对BmNPV抗性基因及作用机制的研究、2004/1-2006/12、21万、结题、主持。

9. 中央与地方高校共建、家蚕功能基因组计划技术平台建设、2003-2004、1000万、完成、主持。

10. 省教育厅产业化、JH03-034、家蚕抗病基因筛选及其分子标记、2003/9-2006/9、8万、结题、主持。

11. 江苏省有突出贡献的中青年专家,2002年,生命科学。

12. 江苏省333第二层次,2002年,生命科学。

13. 国家重点自然科学基金、39730730、家蚕特优基因资源及定向遗传改良的基础、1998/1 - 2000/12、90万、优秀结题、参加单位主持。

14. 国家“九·五”科技攻关项目、96-606-02-01、新型优质蚕品种选育、1996/1-2000/12、314万、优秀结题、副主持。

15. 国家青年自然科学基金、39270537、家蚕对核型多角体病毒病抗性遗传规律研究、1993/1-1995/12、4万、已结题、主持。

主要论著(*为通讯作者)

2015

1. Chen L, Chen H, Yao C, Chang C, Xia H, Zhang C, Zhou Y, Yao Q, Chen KP*. The toxicity of NaF on BmN cells and a comparative proteomics approach to identify protein expression changes in cells under NaF-stress: Impact of NaF on BmN cells. Journal of Hazardous Materials, 2015, 286:624-631.

2. Chen L, Lü X, Cao W, Zhang C, Xu R, Meng X, Chen KP*. An investigation and evaluation on species and characteristics of pathogenic microorganisms in Chinese local hospital settings. Microb Pathog, 2015, 89:154-160.

3. Yang Y, Dai L, Zhu K, Xia H, Chen L, Liu H, Chen K*. Foreign Protein Detection in Transgenic Rice Revealed by Comparative Proteomic Analysis. Crop Science, 2015, 55(5):2225-2233.

4. Hao LJ, Lü P, Gao L, Zhou Y, Yao Q, Yang YH, Chen KP*. Identification and characterization of theBombyx mori myosin II essential light chain and its effect in BmNPV infection. Invertebrate Survival Journal, 2015, 12:38-45.

5. Ma SS, Kang ZQ, Lu P, Yang YH, Yao Q, Xia HC, Chen KP*. Molecular and Physiological Characterization of Two Novel Multirepeat beta-Thymosins from Silkworm,Bombyx mori. PLoS ONE, 2015, 10(10):e0140182.

6. Ma SS, Zhang Z, Xia HC, Chen L, Yang YH, Yao Q, Chen KP*. Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts. Genet Mol Res, 2015, 14(3):9963-9973.

7. Tang Q, Hu ZY, Yang YH, Wu HL, Qiu LP, Chen KP, Li GH. Overexpression of Bm65 correlates with reduced susceptibility to inactivation by UV light. J Invertebr Pathol, 2015, 127:87-92.

2014

1. Chen, L., You, Z., Xia, H., Tang, Q., Zhou, Y., Yao, Q., Chen, K*. Spatiotemporal expression profile of the Pumilio gene in the embryonic development of silkworm. Z Naturforsch C, 2014, 69(7-8):317-324.

2. Feng, F., L. Chen, C. Lian, H. Xia, Y. Zhou, Q. Yao, K. Chen*. Comparative proteomic analysis reveals the suppressive effects of dietary high glucose on the midgut growth of silkworm. J Proteomics, 2014, 108:124-132.

3. Han, Y., H. Xia, Q. Tang, Lu, S. Ma, Y. Yang, D. Shao, Q. Ma, K. Chen*. TheBombyx mori nucleopolyhedrovirus Bm111 affects virulence but not virus replication. Curr Microbiol, 2014, 69(1):56-62.

4. Hou, Y., Zhang, Z., Xu, Q., Wang, H., Xu, Y., Chen, K. Inhibitor of growth 4 induces NFkappaB/p65 ubiquitin-dependent degradation. Oncogene,2014,33(15):1997-2003.

5. Huang, G., Yang, D., Sun, C., Huang, J., Chen, K., Zhang, C., Chen, H., Yao, Q. A quicker degradation rate is yielded by a novel kind of transgenic silk fibroin consisting of shortened silk fibroin heavy chains fused with matrix metalloproteinase cleavage sites. Journal of Materials Science: Materials in Medicine, 2014,25(8):1833-1842.

6. Hu, P., F. Feng, H. Xia, L. Chen, Q. Yao, K. Chen*. Molecular cloning and characterization of aBombyx mori gene encoding the transcription factor Atonal. Z Naturforsch C, 2014, 69(3-4):155-164.

7. Lian, C., Y. Zhou, F. Feng, L. Chen, Q. Tang, Q. Yao, K. Chen*. Surface display of human growth hormone on Bacillus subtilis spores for oral administration. Curr Microbiol, 2014, 68(4):463-471.

8. Qin, L., Shi, H., Xia, H., Chen, L., Yao, Q., Chen, K. Comparative proteomic analysis of midgut proteins from male and femaleBombyx mori (Lepidoptera: Bombycidae). J Insect Sci, 2014, 14.

9. Wang, X.H., Wang, Y., Zhang, D.B., Liu, A.K., Yao, Q., Chen, K.P. A genome-wide identification of basic helix-loop-helix motifs in Pediculus humanus corporis (Phthiraptera: Pediculidae). J Insect Sci, 2014,14:195.

10. Wang, Z., Chen, Y., Fang, H.D., Shi, H.F., Chen, K.P., Zhang, Z.Y., Tan, X.L. Selection of reference genes for quantitative reverse-transcription polymerase chain reaction normalization inBrassica napus under various stress conditions. Molecular Genetics and Genomics, 2014,289(5):1023-1035

11. Wang, Z., Fang, H.D., Chen, Y., Chen, K.P., Li, G.Y., Gu, S.L., Tan, X.L. Overexpression of BnWRKY33 in oilseed rape enhances resistance to Sclerotinia sclerotiorum. Molecular Plant Pathology, 2014,15(7):677-689.

12. Yang, Y., Zhu, K., Xia, H., Chen, L., Chen, K. Comparative proteomic analysis of indica and japonica rice varieties. Genet Mol Biol,2014,37(4):652-661.

13. You, C., Yang, Y., Zhang, L., Chen, H., Chen, Y., Chen, K., Zhou, Y. Comparative proteomics analysis of global cellular stress responses to hydroxyurea-induced DNA damage in HeLa cells. Cytotechnology, 2014,1-12.

14. Yuan, Y., F. Feng, L. Chen, Q. Yao, K. Chen*. Surface display of Acetobacter pasteurianus AdhA on Bacillus subtilis spores to enhance ethanol tolerance for liquor industrial potential. European Food Research and Technology, 2014, 238(2):285-293.

15. Zhu, K.M., Min, C., Xia, H.C., Yang, Y.H., Wang, B., Chen, K.P*. Characterisation of Indica Special Protein (ISP), amarkerprotein for thedifferentiation of Oryza sativasubspecies indica and japonica. International Journal of Molecular Sciences, 2014,15(5):7332-7343.

2013

1. Feng, F.,Hu, L. Chen, Q. Tang, C. Lian, Q. Yao, K. Chen*. Display of human proinsulin on the Bacillus subtilis spore surface for oral administration. Curr Microbiol, 2013, 67(1):1-8.

2. Feng, F., P.Hu, K. Chen*.Progress of antiviral mechanisms in the mulberry silkworm: A review. African Journal of Microbiology Research, 2013,7(14):1173-1178.

3. Gao, L., Cui, J., Zhou, Y., Chen, L., Zhang, C., Chen, K., Lian, C., Li, L., Li, H., Liang, J. A strategy for sequencing based on rolling-circle amplification on a microarray. J Biomed Nanotechnol, 2013,9(4):615-620.

4. Hu, Z.Y., Li, G.H., Li, G.T., Yao, Q., Chen, K.P.Bombyx mori bidensovirus: The type species of the new genus Bidensovirus in the new family Bidnaviridae. Chinese Science Bulletin 58, 2013, 58(36):4528-4532.

5. Li, G.H., Hu, Z.Y., Guo, X.L., Li, G.T., Tang, Q., Wang, P., Chen, K.P., Yao, Q. Identification ofBombyx mori bidensovirus VD1-ORF4reveals anovelproteinassociated withviralstructuralcomponent. Current Microbiology, 2013, 66(6):527-534.

6. Liu, A., Wang, Y., Zhang, D., Wang, X., Song, H., Dang, C., Yao, Q., Chen, K. Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis. Molecular Genetics and Genomics,2013, 1-16.

7. Lü, P., H. Xia, L. Gao, Y. Pan, Y. Wang, X. Cheng, H. Lu, F. Lin, L. Chen, Q. Yao, X. Liu, Q. Tang, K. Chen*. V-ATPase is involved in silkworm defense response against nucleopolyhedrovirus. PLoS One, 2013, 8(6):e64962.

8. Qiu, L.P.,K.P. Chen*. Anti-HBV agents derived from botanical origin. Fitoterapia, 2013, 84:140-157.

9. Shen, H., Wang, R., Han, Q., Zhang, W., Nin, B., Zhou, Y., Shao, S., Yao, Q., Chen*, K., Liu, X. Characterization ofBombyx mori nucleopolyhedrovirus Bm17. J Basic Microb,2013,53(10):808-814.

10. Tang, Q., G. Li, Q. Yao, L. Chen,Lv, C. Lian, K. Chen*. Bm91 is an envelope component of ODV but is dispensable for the propagation ofBombyx mori nucleopolyhedrovirus. J Invertebr Pathol, 2013, 113(1):70-77.

11. Tang, Q., Li, G., Yao, Q., Chen, L., Feng, F., Yuan, Y., Chen, K*. Bm65 isessential for thepropagation ofBombyx mori nucleopolyhedrovirus. Current Microbiology, 2013, 66(1):22-29.

12. Yang, Y., Dai, L., Xia, H., Zhu, K., Liu, H., Chen, K*. Protein profile of rice (Oryza sativa) seeds. Genetics and Molecular Biology, 2013,36(1):087-092.

13. Yang, Y., Dai, L., Xia, H., Zhu, K., Liu, X., Chen, K*. Comparative proteomic analysis of resistant and susceptible rice cultivars of rice stripe disease. Australian Journal of Crop Science, 2013,7(5):588-593.

14. You, Z., C. Sun, L. Chen, Q. Yao, K. Chen*. A novel method of silkworm embryo preparation for immunohistochemistry. Biotechnol Lett, 2013, 35(8):1209-1214.

15. Yuan, Y., Feng, F., Chen, L., Yao, Q., Chen*, K. Directional isolation of ethanol-tolerant acetic acid bacteria from industrial fermented vinegar. European Food Research and Technology, 2013,1-6.

16. Zhang, D.B., Wang, Y., Liu, A.K., Wang, X.H., Dang, C.W., Yao, Q., Chen, K.P. Phylogenetic analyses of vector mosquito basic helix-loop-helix transcription factors. InsectMolecularBiology,2013,22(5):608-621.

17. Zhou, Y., L. Gao, H. Shi, H. Xia, L. Gao, C. Lian, L. Chen, Q. Yao, K. Chen*, X. Liu. Microarray analysis of gene expression profile in resistant and susceptibleBombyx mori strains reveals resistance-related genes to nucleopolyhedrovirus. Genomics, 2013, 101(4):256-262.

18. Zhou, Y., Ni, Z., Chen, K.P., Liu, H.J., Chen, L., Lian, C.Q., Yan, L.R. Modelingprotein-peptiderecognitionbased onclassicalquantitativestructure-affinityrelationshipapproach:implication forproteome-wideinference ofpeptide-mediatedinteractions. Protein Journal,2013,32(7):568-578.

2012

1. Chen, H.Q., Q. Yao, F. Bao, K.P. Chen*, X.Y. Liu, J. Li, L. Wang. Comparative proteome analysis of silkworm in its susceptibility and resistance responses toBombyx mori densonucleosis virus. Intervirology, 2012, 55(1):21-28.

2. Feng, F., J. Fu, Hu, X. Zhang, Q. Yao, K. Chen*.Genetic analysis of baculovirus resistance inLepidopteran model insectBombyx mori L. African Journal of Biotechnology, 2012, 11(79):14417-14421.

3. Feng, F., H. Shi, J. Fu, L. Qin, X. Zhang, X. Liu, K. Chen*, Q. Yao. Double molecular markers-assisted breeding of silkworm,Bombyx mori, resistant to the virus, BmNPV and BmDNV-Z. Indian Journal of Animal Research, 2012, 46(2):107-113.

4. Liu, A., Wang, Y., Dang, C., Zhang, D., Song, H., Yao, Q., Chen, K. A genome-wide identification and analysis of the basic helix-loop-helix transcription factors in the ponerine ant, Harpegnathos saltator. BMC Evol Biol, 2012,12:165.

5. Mao, L., S. Jiang, G. Li, Y. He, L. Chen, Q. Yao, K. Chen*. Surface display of human serum albumin on Bacillus subtilis spores for oral administration. Curr Microbiol, 2012, 64(6):545-551.

6. Qin, L., H. Xia, H. Shi, Y. Zhou, L. Chen, Q. Yao, X. Liu, F. Feng, Y. Yuan, K. Chen*. Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance toBombyx mori nuclear polyhedrosis virus. J Proteomics, 2012, 75(12):3630-3638.

7. Ren, Q., Du, Z.Q., Li, M., Zhang, C.Y., Chen, K.P. Cloning and expression analysis of an anti-lipopolysaccharide factor from giant freshwater prawn, Macrobrachium rosenbergii. Mol Biol Rep,2012,39(7):7673-7680.

8. Shen, H., K. Chen*. BM61 ofBombyx mori nucleopolyhedrovirus: its involvement in the egress of nucleocapsids from the nucleus. FEBS Lett, 2012, 586(7):990-995.

9. Shen, H., Y. Zhou, W. Zhang, B. Nin, H. Wang, X. Wang, S. Shao, H. Chen, Z. Guo, X. Liu, Q. Yao, K. Chen*. Characterization ofBombyx mori nucleopolyhedrovirus with a knockout of Bm17. Cytotechnology, 2012, 64(6):711-718.

10. Wang, B., Kang, L., Xia, H., Zhu, K., Guo, M., Liu, X., Yao, Q., Chen*, K. Construction of a proteomic reference map for analysis of development of etiolated rice seedlings. African Journal of Agricultural Research,2012,7(6):902-917.

11. Yang, Y., Chen, K. Molecular evolution of the ent-kaurenoic acid oxidase gene in Oryzeae. Genet Mol Biol,2012,35(2):448-454.

12. Zhou, Y., Mo, J.C., Chen, K.P., Xu, Q.G. Isolation andcharacterization of P450gene from the Formosan Subterranean Termite, Coptotermes formosanus (Isoptera: Rhinotermitidae). Sociobiology,2012,59(4):1121-1135.

13. Zhu, S.L., Li, G.H., Hu, Z.Y., Chen, K.P., Li, G.T., Guo, X.L., Ma, Y., Yao, Q. Characterization of thepromoterelements ofBombyx mori bidensovirusnonstructuralgene 1. Current Microbiology,2012,65(5):643-648.

2011

1. Cao, J., He, Y., Li, G., Chen, K., Kong, J., Wang, F., Shi, J., Yao, Q. Detection of the expression of aBombyx mori atypicalproteinkinase C in BmPLV-infectedlarvalmidgut. International Journal of Industrial Entomology,2011,22(2):59-64.

2. Chang, C., Liu, X., Chen, K*. Molecular cloning, expression and characterization of a novel gene β-N-acetylglucosaminidase fromBombyx mori. Advances in Bioscience and Biotechnology,2011, 2011(2):123-127.

3. Dang, C.W., Wang, Y., Chen, K.P., Yao, Q., Zhang, D.B., Guo, M. The basic helix-loop-helix transcription factor family in the pea aphid, Acyrthosiphon pisum. Journal of Insect Science,2011,11.

4. Dang, C., Wang, Y., Zhang, D., Yao, Q., Chen, K. A genome-wide survey on basic helix-loop-helix transcription factors in giant panda. PLoS One,2011,6(11):e26878.

5. Guo, M., Y. Wang, J. Shi, L. Kang, Q. Yao, F. Wang, L. Qin, K. Chen*. Molecular cloning and characterization of twist gene inBombyx mori. Mol Cell Biochem, 2011, 348(1-2):69-76.

6. Kang, L., H. Shi, X. Liu, C. Zhang, Q. Yao, Y. Wang, C. Chang, J. Shi, J. Cao, J. Kong, K. Chen*. Arginine kinase is highly expressed in a resistant strain of silkworm (Bombyx mori, Lepidoptera): Implication of its role in resistance toBombyx mori nucleopolyhedrovirus. Comp Biochem Physiol B Biochem Mol Biol, 2011, 158(3):230-234.

7. Kang, L., H. Shi, N. Wang, Y. Chen, Q. Yao, Y. Zhou, Y. Wang, H. Chen, M. Guo, F. Wang, K. Chen*. Cloning, purification and characterization of recombinant silkworm arginine kinase expressed in Escherichia coli. African Journal of Biotechnology, 2011, 10(36):7026-7033.

8. Kong, J., Hu, Z.G., He, Y.Q., Li, G.H., Cao, J., Wang, F.H., Chen, K.P., Yao, Q. Expression analysis ofBombyx mori parvo-like virus VD2-ORF1 gene encoding a minor structural protein. Biologia,2011,66(4):684-689.

9. Li, G., Tang, Q., Chen, H., Yao, Q., Ning, D., Chen*, K. Display ofBombyx mori nucleopolyhedrovirus GP64 on the Bacillus subtilis spore coat. Curr Microbiol,2011,62(5):1368-1373.

10. Lin, F., Chen*, K., Xia, H., Yao, Q., Gao, L., Chen, H. Characterization of a Late Gene, ORF134, fromBombyx mori nucleopolyhedrovirus. Intervirology,2011,54(3):113-121.

11. Liu, J.B., F.L. Qiang, J. Dong, J. Cai, S.H. Zhou, M.X. Shi, K.P. Chen*, Z.B. Hu. Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma. World J Gastroenterol, 2011, 17(44):4917-4921.

12. Liu, J.B., Y.X. Zhang, S.H. Zhou, M.X. Shi, J. Cai, Y. Liu, K.P. Chen*, F.L. Qiang. CpG island methylator phenotype in plasma is associated with hepatocellular carcinoma prognosis. World J Gastroenterol, 2011, 17(42):4718-4724.

13. Lu, J., Xu, Q.G., Chen, H.Y., Li, J., Chen*, K.P. Comparative proteomics analysis of midgut samples from Takifugu rubripes exposed to excessive fluoride: initial molecular response to fluorosis. Toxicol Mech Method,2011,21(6):444-452.

14. Lu, J., Zheng, J.Z., Xu, Q.G., Chen*, K.P., Zhang, C.Y. Adaptive evolution of the vertebrate skeletal muscle sodium channel. Genetics and Molecular Biology,2011,34(2):323-U304.

15. Lü, M., Yao, Q., Wang, Y., Liu, X., Liu, H., Huang, G., Chen, K., Zhang, J., Li, X. Identification ofstructuralproteins ofBombyx mori parvo-likevirus (China Zhenjiang Isolate). Intervirology,2011, 54(1):37-43.

16. Mao, L., S. Jiang, B. Wang, L. Chen, Q. Yao, K. Chen*. Protein profile of Bacillus subtilis spore. Curr Microbiol, 2011, 63(2):198-205.

17. Ren, Q., Li, M., Zhang, C.Y., Chen, K.P. Six defensins from the triangle-shell pearl mussel Hyriopsis cumingii. Fish Shellfish Immun,2011,31(6):1232-1238.

18. Wang, N., C. Chang, Q. Yao, G. Li, L. Qin, L. Chen, K. Chen*. Display ofBombyx mori alcohol dehydrogenases on the Bacillus subtilis spore surface to enhance enzymatic activity under adverse conditions. PLoS One, 2011, 6(6):e21454.

19. Wang, N., H. Shi, Q. Yao, Y. Zhou, L. Kang, H. Chen, K. Chen*.Cloning, expression and characterization of alcohol dehydrogenases in the silkworm Bombyx mori. Genet Mol Biol, 2011, 34(2):240-243.

20. Wang, F.H., Hu, Z.Y., He, Y.Q., Li, G.H., Kong, J., Cao, J., Chen, K.P., Yao, Q. The non-structural protein NS-2 ofBombyx mori parvo-like virus is localized to the nuclear membrane. Current Microbiology,2011,63(1):8-15.

21. Xia, H., C. Wu, Q. Xu, J. Shi, F. Feng, K. Chen*, Q. Yao, Y. Wang, L. Wang. Molecular cloning and characterization of lactate dehydrogenase gene 1 in the silkworm,Bombyx mori. Mol Biol Rep, 2011, 38(3):1853-1860.

2010

1. Chen, H., G. Li, G. Huang, K. Chen*, Q. Yao, Z. Guo. Characterization of ORF29 ofBombyx mori nucleopolyhedrovirus. Acta Virol, 2010, 54(4):275-280.(病毒)

2. Chen, H., Y. Li, K. Chen*, Q. Yao, G. Li, L. Wang. Comparative proteomic analysis ofBombyx mori hemolymph and fat body after calorie restriction. Acta Biochim Pol, 2010, 57(4):505-511.

3. Guo, Z.J., L.H. Qiu, S.H. An, Q. Yao, E.Y. Park, K.P. Chen*, C.X. Zhang. Open reading frame 60 of theBombyx mori nucleopolyhedrovirus plays a role in budded virus production. Virus Res, 2010, 151(2):185-191.

4. Guo, Z.J., D.X. Wang, Q. Yao, K.P. Chen*, C.X. Zhang. Identification of a novel functional nuclear localization signal in the protein encoded by open reading frame 47 ofBombyx mori nucleopolyhedrovirus. Arch Virol, 2010, 155(12):1943-1950.

5. Huang, G., Li, G., Chen, H., He, Y., Yao, Q., Chen*, K. Proteomic analysis of 3T3-L1 preadipocytes having a higher cell proliferation rate after treatment with low-molecular-weight silk fibroin peptides. Cell Proliferat,2010,43(5):515-527.

6. Huo, J., H. Shi, Q. Yao, H. Chen, L. Wang, K. Chen*. Cloning and purification of recombinant silkworm dihydrolipoamide dehydrogenase expressed in Escherichia coli. Protein Expr Purif, 2010, 72(1):95-100.

7. Li, X.G., Xia, H.C., He, Y.Q., Gao, L., Zhou, Y., Li, G.H., Chen, K.P., Yao, Q. Cloning and characterization of the densoviruses susceptible gene +(nsd-2) in the silkworm,Bombyx mori. African Journal of Biotechnology,2010,9(25):736-3741.

8. Liang, G., G. Li, K. Chen*, Q. Yao, H. Chen, Y. Zhou.Bombyx mori nucleopolyhedrovirus ORF94, a novel late protein is identified to be a component of ODV structural protein. Curr Microbiol, 2010, 61(3):190-196.

9. Lin, F., Q. Yao, H. Chen, Y. Zhou, K. Chen*.Differential expression of early viral gene BmORF51 inBombyx mori nucleopolyhedrovirus infection of resistant and susceptible silkworms. African Journal of Biotechnology, 2010, 9 (25):3742-3747.

10. Liu, X., K. Chen, Q. Yao*, H. Xia. Proteomic analysis of differentially expressed proteins involved in BmNPV resistance in the fat body of silkworm,Bombyx mori. Z Naturforsch C, 2010, 65(11-12):713-718.

11. Liu, X., Q. Yao, Y. Wang, K. Chen*, Proteomic analysis of nucleopolyhedrovirus infection resistance in the silkworm,Bombyx mori (Lepidoptera: Bombycidae). J Invertebr Pathol, 2010, 105(1):84-90.

12. Lu, J., Zheng, J.Z., Liu, H.J., Li, J., Xu, Q.G., Chen, K.P. Proteomicsanalysis ofliversamples frompufferfish Takifugu rubripesexposed toexcessivefluoride:aninsight intomolecularresponse tofluorosis. J Biochem Mol Toxic,2010,24(1):21-28.

13. Lu, J., Chen, H.Y., Xu, Q.G., Zheng, J.Z., Liu, H.J., Li, J., Chen, K.P. Comparative proteomics of kidney samples from puffer fish Takifugu rubripes exposed to excessive fluoride: An insight into molecular response to fluorosis. Toxicol Mech Method,2010,20(6):345-354.

14. Lu, J., Zheng, J.Z., Liu, H.J., Li, J., Chen, H.Y., Chen, K.P. Protein profiling analysis of skeletal muscle of a pufferfish, Takifugu rubripes. Mol Biol Rep,2010,37(5):2141-2147.

15. Lü, P., K. Chen*, Q. Yao, L. Gao, Y. Pan, Y. He, G. Huang, L. Wang. Expression and localization ofBombyx mori V-ATPase 16 kDa subunit c. Z Naturforsch C, 2010, 65(1-2):119-126.

16. Pan, Y., K. Chen*, H. Xia, Q. Yao, L. Gao,Lu, Huojuan, Y. He, L. Wang. Molecular cloning, expression and characterization of BmIDGF gene from Bombyx mori. Z Naturforsch C, 2010, 65(3-4):277-283.

17. Xu, Q.G., Zhou, Y., Li, J., Chen, H.Y., Lu, J.A., Chen, K.P., Mo, J.C., Zhu, M.Y., Zhang, C.Y. Diversifyingevolution ofendo-beta-1,4-glucanase intermites (Isoptera). Sociobiology,2010,56(3):623-636.

18. Zhang, J., G. Li, H. Chen, X. Li, M. Lv, K. Chen, Q. Yao*. Molecular cloning and expression of key gene encoding hypothetical DNA polymerase from B. mori parvo-like virus. Genet Mol Biol, 2010, 33(4):739-744.

19. Zhou, Y., K. Chen*, Q. Yao, H. Shen, G. Liang, X. Li, N. Wang, Y. Li. Characterization of a late expression gene ofBombyx mori nucleopolyhedrovirus. Z Naturforsch C, 2010, 65(7-8):508-518.

20. Zhou, Y., Q. Yao, H. Shen, H. Xia, F. Lin, K. Chen*. Characterization ofBombyx mori nucleopolyhedrovirus ORF109 that encodes a 25-kDa structural protein of the occlusion-derived virion. Curr Microbiol, 2010, 61(5):451-457.

21. Zhu, Y.M., G.H. Li, Q. Yao, K.P. Chen*, Z.J. Guo. Characterization of the Open reading frame 35 ofBombyx mori nucleopolyhedrovirus. International Journal of Industrial Entomology, 2010, 21(2):157-162.

2009

1. Chen, T., Chen*, K. Investigation andapplicationprogress of Verocellserum-freeculture. International Journal of Biology,2009,1(2):41-47.

2. Chi, G., L. Gao, K. Chen*, Q.Y. Yao, Z. Yang, H. Chen, L. Wang. Preliminary characterization of a death-related gene in silkwormBombyx mori. African Journal of Biotechnology, 2009, 8(10):2118-2124.

3. Ding, N., Wu, N.N., Xu, Q.G., Chen*, K.P., Zhang, C.Y. Molecular evolution of novel swine-origin A/H1N1 influenza viruses among and before human. Virus Genes,2009,39(3):293-300.

4. Li, G., C. Sun, J. Zhang, Y. He, H. Chen, J. Kong, G. Huang, K. Chen*, Q. Yao. Characterization ofBombyx mori parvo-like virus non-structural protein NS1. Virus Genes, 2009, 39(3):396-402.

5. Li, Y., K. Chen, Q. Yao, J. Li, Y. Wang, H. Liu, C. Zhang, G. Huang. The effect of calorie restriction on growth and development in silkworm,Bombyx mori. Arch Insect Biochem Physiol, 2009, 71(3):159-172.

6. Lu, J., Xu, Q.G., Zheng, J.Z., Liu, H.J., Li, J., Chen, K.P. Comparative proteomics analysis of cardiac muscle samples from pufferfish Takifugu rubripes exposed to excessive fluoride: Initial molecular response to fluorosis. Toxicol Mech Method,2009,19(6-7):468-475.

7. Pan, Y., H. Xia,Lu, K. Chen*, Q. Yao, H. Chen, L. Gao, Y. He, L. Wang. Molecular cloning, expression and characterization of Bmserpin-2 gene from Bombyx mori. Acta Biochim Pol, 2009, 56(4):671-677.

8. Qin, L., X. Liu, J. Li, H. Chen, Q. Yao, Z. Yang, L. Wang, and K. Chen*. Protein profile of Nomuraea rileyi spore isolated from infected silkworm. Curr Microbiol, 2009, 58(6):578-585.

9. Shen, H., K. Chen*, Q. Yao, W. Yu, Y. Pan, J. Huo, H. Xia, G. Huang. Characterization ofBombyx mori nucleopolyhedrovirus orf74, a novel gene involved in virulence of virus. Virus Genes, 2009, 38(3):487-494.

10. Shen, H., K. Chen*, Q. Yao, Y. Zhou.Characterization of the Bm61 of theBombyx mori nucleopolyhedrovirus. Curr Microbiol, 2009, 59(1):65-70.

11. Tian, B., K. Chen*, Q. Yao, H. Chen, Z. Yang, J. Zhou. Isolation and characterization of a PUF-domain pumilio gene from silkwormBombyx mori. African Journal of Biotechnology, 2009, 8(6):986-994.

12. Wang, Y., Chen*, K.P., Yao, Q., Zheng, X.D., Yang, Z. Phylogeneticanalysis ofzebrafishbasichelix-loop-helixtranscriptionfactors. J Mol Evol,2009,68(6):629-640.

13. Xia, H., H. Lv, K. Chen*, Q. Yao,Lv, J. Li, H. Chen, L. Wang. Cloning and characterization of peptidylprolyl isomerase B in the silkworm,Bombyx mori. African Journal of Biotechnology, 2009, 8 (24):7116-7124.

14. Yang, H., H. Chen, K. Chen*, Q. Yao, G. Zhao, C. Wu, P. Lü, L. Wang.Characterization and localization of the vacuolar-type ATPase in the midgut cells of silkworm (Bombyx mori). Z Naturforsch C, 2009, 64(11-12):899-905.

15. Zheng, J., Lu, J., Liu, H., Li, J., Chen*, K. Sequence and structural analysis of 4SNc-Tudor domain protein from Takifugu Rubripes. Bioinformation,2009, 4(3):127-131.

16. Zheng, X., Wang, Y., Yao, Q., Yang, Z., Chen, K*. A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse. Mammalian Genome,2009, 20(4):236-246.

2008

1. Cai, K., K. Chen*, X. Liu, Q. Yao, J. Li. Differential expression of haemolymph proteome of resistant strain and susceptible strain for BmNPV inBombyx mori L. Chinese Journal of Biotechnology, 2008, 24(2):285-290.

2. Liu, X., K. Chen*, K. Cai, Q. Yao. Determination of protein composition and host-derived proteins ofBombyx mori nucleopolyhedrovirus by 2-dimensional electrophoresis and mass spectrometry. Intervirology, 2008, 51(5):369-376.

3. Lü, H., K. Chen*, Q. Yao, L. Wang.Cloning and Characterization of hydroxypyruvate isomerase (EC 5.3.1.22) gene in silkwormBombyx mori. International Journal of Industrial Entomology, 2008, 17(2):189-195.

4. Wang, H., K. Chen*, Z. Guo, Q. Yao.Bombyx mori nucleopolyhedrovirus orf25 encodes a 30kDa late protein in the infection cycle. Acta microbiologica Sinica, 2008, 48(2):247-251.

5. Wang, Q., K. Chen*, Q. Yao, Y. Zhao, Y. Li, H. Shen, R. Mu.Identification and characterization of a novel 1-Cys peroxiredoxin from silkworm,Bombyx mori. Comp Biochem Physiol B Biochem Mol Biol, 2008, 149(1):176-182.

6. Wang, Y., Chen*, K.P., Yao, Q., Wang, W.B., Zhu, Z. The basic helix-loop-helix transcription factor family in the honey bee, Apis mellifera. Journal of Insect Science,2008, 8.

7. Wu, C., Z. Guo, K. Chen*, H. Shen. High-level expression, polyclonal antibody preparation and bioinformatics analysis ofBombyx mori nucleopolyhedrovirus orf47 encodes protein. International Journal of Industrial Entomology, 2008, 16(2):87-92.

8. Xu, J.P., Chen*, K.P., Liu, M.H., Yao, Q., Gao, G.T., Zhao, Y. Identification and characterization of Bms3a inBombyx mori L. African Journal of Biotechnology,2008,7(19):3424-3430.

9. Yin, H., Q. Yao, Z. Guo, F. Bao, W. Yu, J. Li, K. Chen*. Expression of non-structural protein NS3 gene ofBombyx mori densovirus (China isolate). J Genet Genomics, 2008, 35(4):239-244.

10. Yu, W., Q. Yao, Z. Guo, F. Bao, H. Yin, K. Chen*. Expression of non-structural protein 1 ofBombyx mori densovirus-3. Acta microbiologica Sinica, 2008, 48(2):191-196.

11. Zhao, G., K. Chen*, Q. Yao, W. Wang.Cloning and characterization of nanos gene in silkwormBombyx mori. J Genet Genomics, 2008, 35(2):77-83.

12. Zhao, G., K. Chen*, Q. Yao, W. Wang, Y. Wang, R. Mu, H. Chen, H. Yang, H. Zhou.The nanos gene ofBombyx mori and its expression patterns in developmental embryos and larvae tissues. Gene Expr Patterns, 2008, 8(4):254-260.

13. Zhou, H., K. Chen*, Q. Yao, L. Gao, Y. Wang. Molecular cloning ofBombyx mori cytochrome P450 gene and its involvement in fluoride resistance. J Hazard Mater, 2008, 160(2-3):330-336.

14. Zhou, Z.H., H.J. Yang, M. Chen, C.F. Lou, Y.Z. Zhang, K.P. Chen*. Y. Wang, M.L. Yu, F. Yu, J.Y. Li, B.X. Zhong. Comparative proteomic analysis between the domesticated silkworm (Bombyx mori) reared on fresh mulberry leaves and on artificial diet. J Proteome Res, 2008, 7(12):5103-5111.

15. Zhu, M., K. Chen*, Y. Wang, Z. Guo, H. Yin, Q. Yao, H. Chen. Cloning and partial characterization of a gene inBombyx mori homologous to a human adiponectin receptor. Acta Biochim Pol, 2008, 55(2):241-249.

2007

1. Chen, H.Q., K.P. Chen*, Q. Yao, Z.J. Guo, L.L. Wang. Characterization of a late gene, ORF67 fromBombyx mori nucleopolyhedrovirus. FEBS Lett, 2007, 581(30):5836-5842.

2. Chen*, K., Chen, H., Tang, X., Yao, Q., Wang, L., Han, X. bmpkci is highly expressed in a resistant strain of silkworm (Lepidoptera: Bombycidae):implication of its role in resistance to BmDNV-Z. European Journal of Entomology,2007,104(3):369-376.

3. Han, X., Q. Yao, L. Gao, Y.J. Wang, F. Bao, K.P. Chen*. Replication ofBombyx mori densonucleosisvirus (Zhenjiang isolate) in different silkworm strains. Chinese Journal of Biotechnology, 2007, 23(1):145-151.

4. Lü, P., K. Chen*, Qin Yao, H. Yang. Molecular cloning, bioinformatics analysis and expression profiling of a gene encoding Vacuolar-type H+-ATP synthetase (V-ATPase) c subunit fromBombyx mori. International Journal of Industrial Entomology, 2007, 15(2):115-122.

5. Wang, H., K. Chen*, Z. Guo, Qin Yao, Q. Wang, R. Mu.Rapid expression of Bm46 inBombyx mori cell lines, larvae and pupae. International Journal of Industrial Entomology, 2007, 15(1):35-38.

6. Wang, Q., Z.J. Guo, Q. Yao, H.Y. Wang, K.P. Chen*. Rapid disruption ofBombyx mori nucleopolyhedrovirus orf60 by red recombination system. Chinese Journal of Biotechnology, 2007, 23(5):801-805.

7. Wang, Y., K. Chen*, Q. Yao, W. Wang, Z. Zhi.The basic helix-loop-helix transcription factor family inBombyx mori. Dev Genes Evol, 2007, 217(10):715-723.

8. Wang, Y.J., K.P. Chen*, Q. Yao, X. Han. Transcriptional analysis of the DNA polymerase gene ofBombyx mori parvo-like virus (China isolate). J Microbiol, 2007, 45(2):139-145.

9. Wang, Y.J., Q. Yao*, K.P. Chen, Y. Wang, J. Lu, X. Han. Characterization of the genome structure ofBombyx mori densovirus (China isolate). Virus Genes, 2007, 35(1):103-108.

10. Yang, H., K. Chen*, Q. Yao, Z. Guo. Cloning and characterization of 6-phosphogluconolactonase gene in silkwormBombyx mori. International Journal of Industrial Entomology, 2007, 14(2):69-74.

11. Zhao, Y., K. Chen*, He, S. Key principles for breeding spring and autumn using silkworm varieties: from our experience of breeding 873×874. Caspian Journal of Environmental Science,2007, 5(1):57-61.

12. Zhao, Y., Q. Yao, X. Tang, Z. Hu, J. Lu, K. Chen*. Cloning and homologic analysis of Tpn I gene in silkwormBombyx mori. Journal of Applied Entomology, 2007, 6(6):672-676.

13. Zhu, M., K. Chen*, Q. Yao.Identification and characterization ofBombyx mori LDH gene through bioinformatics approaches. International Journal of Industrial Entomology, 2007, 15(2):137-143.

2006

1. Gao, L., K. Chen*, Q. Yao, H. Chen. BmNPV infection enhances ubiquitin-conjugating enzyme E2 expression in the midgut of BmNPV susceptible silkworm strain. International Journal of Industrial Entomology, 2006, 13(1):31-35.

2. Hu, Z., K. Chen*, L. Gao, Q. Yao. RNA interference to preventBombyx mori nuclear polyhedrosis virus infection in Vivo. International Journal of Industrial Entomology, 2006, 12(1):15-19.

3. Hu, Z.G., K.P. Chen*, Q. Yao, G.T. Gao, J.P. Xu, H.Q. Chen. Cloning and characterization ofBombyx mori PP-BP a gene induced by viral infection. Acta Genetica Sinica, 2006, 33(11):975-983.

4. Wang, L.L., K.P. Chen*, Z. Zhang, Q. Yao, G.T. Gao, Y. Zhao. Phylogenetic analysis of Nosema antheraeae (Microsporidia) isolated from Chinese oak silkworm, Antheraea pernyi. J Eukaryot Microbiol, 2006, 53(4):310-313.

5. Wang, Y.J., K.P. Chen*, Q. Yao, G.T. Gao, X. Han. Complete nucleotide sequence analysis ofBombyx mori densonucleosis virus type 3 VD2 (China isolate). Acta microbiologica Sinica, 2006, 46(3):363-367.

6. Wang, Y.J., Q. Yao, K.P. Chen*, X. Han. Organization and transcription strategy of genome ofBombyx mori bidensovirus (China isolate) VD1. Chinese Journal of Biotechnology, 2006, 22(5):707-712.

7. Zhao, Y., K. Chen*, Q. Yao, Y. Wu, J. Zhang, X. Guo. Preliminary report on the breeding of robust and resistant-NPV and high quality silkworm race Shengming No.1 for summer-autumn rearing. International Journal of Industrial Entomology 2006, 13(2):85-95.

2005

1. Hu, Z., K. Chen*, L. Wang, Q. Yao. Identification and characterization ofBombyx mori eIF5A gene through bioinformatics approaches. In Silico Biol, 2005, 5(5-6):573-580.

2. Xu, J.P., K.P. Chen*, Q. Yao, X.Y. Liu. Fluorescent differential display analysis of gene expression for NPV resistance inBombyx mori L. Journal of Applied Entomology, 2005, 129(1):27-31.

3. Xu, J.P., Chen, K.P., Yao, Q., Liu, M.H., Gao, G.T., Zhao, Y. Identification and characterization of an NPV infection-related gene Bmsop2 inBombyx mori L. Journal of Applied Entomology,2005,129(8):425-431.

4. Yao, Q., Z. Hu, J. Xu, K. Chen*. Cloning and characterization of Ribosome-associated Membrane Protein 4 (RAMP4) gene in silkwormBombyx mori. International Journal of Industrial Entomology, 2005, 10(2):125-129.

2004

1. Zhang, C., Yao, Q., Xu, Q., Tang, X.,Chen*, K.P. Screening andcloning of RAPDmarkers from the Wchromosome ofsilkworm,Bombyx mori L. International Journal of Industrial Entomology, 2004,8(2):161-167.

2003

1. Yao, Q., Li, M.W., Wang, Y., Wang, W.B., Lu, J., Dong, Y., Chen, K.P.Screening of molecular markers for NPV resistance inBombyx mori L. (Lep., Bombycidae). Journal of Applied Entomology-Zeitschrift Fur Angewandte Entomologie,2003,127(3):134-136.

2. Chen*, K., Yao, Q., Wang, Y., Cheng, J. Genetic basis of screening of molecular markers for nuclear polyhedrosis virus resistance inBombyx mori L. International Journal of Industrial Entomology, 2003,7(1):5-10.

3. Chen*, K., Yao, Q., Li, M., Wang, Y. Screening of RAPDmarkers forfluorideresistance inBombyx mori L. International Journal of Industrial Entomology, 2003,7(1), 11-14.

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