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侯永忠(博导)

侯永忠、博士、教授、 Email: houyz@mail.ujs.edu.cn。

2007/11- 2012/7 博士后/research associate. University of Calgary, Canada. 2006/4 - 2007/11. 博士后. Kinki University, Japan. 2005/6 - 2006/2 博士后. University of Florida, USA .

研究兴趣

核受体蛋白调控肿瘤发生分子机制、及药物开发

以人肿瘤细胞和小鼠为研究对象,探索并揭示细胞核受体蛋白PPARs (PPARα、 PPARγ、PPARδ)调节肿瘤发生的细胞内信号网络机制,基于这些分子机制筛选以PPARs 为靶点的天然或合成抗肿瘤化合物。

近年发表主要论文(# 通讯作者)

1. Xu Y, Jin J, Zhang Z, Zhang W, Gao J, Liu Q, Zhou C, Shi H, Hou Y#, Shi J#. EGFR/MDM2 signaling promotes NFkB activation via PPARg degradation. Carcinogenesis, 2016 Dec 30. pii: bgv252.

2.Gao J, Liu Q, Xu Y, Gong X, Zhang R, Zhou C, Su Z, Jin J, Shi H, Shi J#,Hou Y#. PPARα induces cell apoptosis by destructing Bcl2.Oncotarget. 2015 Nov 9. doi: 10.18632/oncotarget.5988.

3. You M, Yuan S, Shi J,Hou Y #.PPARδ signaling regulates colorectal cancer. Current Pharmaceutical Design. 2015; 21(21):2956-9

4. Xu H, You M, Shi H,Hou Y#. Ubiquitin-mediated NFκB degradation signaling. Cellular & Molecular Immunology. 2015 Nov;12(6):653-5.

5.Hou Y#, Zhang Z, Xu Q, Wang H, Xu Y, Chen K. ING4 induces NFκB/p65 ubiquitin-dependent degradation. Oncogene. 2014, 33:1997-2003.

6.Hou Y#, Gao J, Xu H, Xu Y, Zhang Z, Xu Q, Zhang C. PPARγ E3 ubiquitin ligase regulates MUC1-C oncoprotein stability. Oncogene. 2014, 33:5619-25.

7.Hou Y, France M, Chadee K. PPARγ functions as E3 ubiquitin ligase to terminate NFкB activation. Nature Communications. 2012, 3:1300.

8.Hou Y,Mortimer L, Chadee K. E. histolytica cysteine proteinase-5 binds integrin on colonic cells and stimulates NFkB-mediated pro-inflammatory response. J. Biol. Chem. 2010. 285, 35497–35504.

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