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周阳(硕导)


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【个人简介】

性别: 男

职称: 副研究员

电话: 15052945866

E-mail: zhouyang@ujs.edu.cn

【学历简介】

学习经历:

1997-2001年南京师范大学学士

2001-2004年安徽农业大学硕士

2007-2010年江苏大学生命科学研究院博士

【研究领域】

1. 游离DNA的功能及在产前筛查、肿瘤、器官移植中的应用

2. 病原微生物感染检测

【科研项目】

(1) 横向课题,1871330003,游离DNA(cell-free DNA, cfDNA)在肾移植免疫排斥中的应用技术开发,2017/12-2020/.12, 200万,主持

(2) 国家自然青年基金,31301919,家蚕氨基酸转运蛋白与其抗BmNPV 功能的研究,2014/01–2016/12,24万,已结题,主持

(3) 江苏省青年基金,BK20130506,基于生物组学方法研究铁代谢调控家蚕免疫和生长分子机制,201307-201606,20万,已结题,主持

(4) 国家自然基金面上项目,31271272,通过蛋白组转录组和基因筛选研究镉诱导生物毒性的机理,201301-201612,80万,已结题,参加(排名第二)

(5) 国家自然青年基金,31200602,基于脂肪酶A 突变体探索无固定结构蛋白催化机制,2012/01–2015/12,23 万元,已结题,参加(排名第二)

(6) 国家自然青年基金,31200209,N-乙酰基高丝氨酸内酯对植物耐盐性的影响及机制分析,2012/01–2015/12,22 万元,已结题,参加(排名第三)

(7) 国家自然青年基金,31101673,家蚕β-N-乙酰氨基葡萄糖苷酶2对核型多角体病毒蛋白糖基化的影响,2011/01–2014/12,24 万元,已结题,参加(排名第三)


【主要著作】

 (1)Yang Zhou, Dandan Yan, Shaofei Yuan,Yawen Chen, EmmanuellaE. Fletcher,Haifeng Shi, Bangxing Han, Selective binding, magnetic separation and purification of histidine-tagged protein using biopolymer magnetic core-shell nanoparticles, Protein Expression and Purification, 2018, 144: 5-11

(2) Yang Zhou, Shaofei Yuan, Qian Liu, Dandan Yan, Yun Wan, Li Gao, Jan Han*, Haifeng Shi*, Synchronized purification and immobilization of his-tagged β-glucosidase via Fe3O4/PMG core/shell magnetic nanoparticles, Scientific Reports, 2017.01.30,2017(7): 41741

(3) Yang Zhou, Jiege Wu, Feng Lin, Naifu Chen, Shaofei Yuan, Lina Ding, Li Gao, Bangxing Hang*, Rapid detection of Bombyx mori nucleopolyhedrovirus (BmNPV) by loop-mediated isothermal amplification assay combined with a lateral flow dipstick method, Molecular and Cellular Probes, 2015, 29(6): 389-395

(4) Yang Zhou, Juan Huo, TingYa Jiang, HengChuan Xia, HaiTao Liu, Xiao Yuan, RongFa Xu, KePing Chen, HaiFeng Shi*, Subcellular Localization, Transcription, Expression, and Activity of Dihydrolipoamide Dehydrogenase (DLDH) During Developmental Stages and in Different Tissues of Silkworm (Lepidoptera: Bombycidae), Annals of the Entomological Society of Amercia, 2015, 108(4): 562-569

(5) Yang Zhou, Zhong Ni, Keping Chen, Haijun Liu, Liang Chen, Chaoqun Lian, Lirong Yan*, Modeling Protein–Peptide Recognition Based on Classical Quantitative Structure–Affinity Relationship Approach: Implication for Proteome-Wide Inference of Peptide-Mediated Interactions, Protein Journal, 2013, 32(7): 568-578

(6) Yang Zhou, Lu Gao, Haifeng Shi, Hengchuan Xia, Li Gao, Chaoqun Lian, Liang Chen, Qin Yao, Keping Chen*, Xiaoyong Liu*, Microarray analysis of gene expression profile in resistant and susceptible Bombyx moristrains reveals resistance-related genes to nucleopolyhedrovirus, Genomics, 2013, 101 (4): 256-262

(7) 周阳,施海峰*,癫痫的遗传学研究进展,安徽医科大学学报,2015,50(3): 406~410

(8) 周阳,庄国庆,林锋,蒋廷亚,袁少飞,高力,施海峰*,锦鲤致病性假单胞菌的分离鉴定及生物学特性研,西南农业学报,2015,28(4): 1830~1833

(9) 周阳,严丽荣,袁少飞,刘海涛,施海峰*,氧化应激与阿尔茨海默病,生命科学研究,2015,19(3): 265~275

(10)周阳,袁少飞,蒋廷亚,韩邦兴,高力,陈乃富*,基因组靶向修饰技术研究进展,生物学杂志,2015,32(5): 70~75

    (11) Feng Lin, Dan-Dan Yan, Ya-Wen Chen, Fletcher Emmanuella E, Haifeng Shi, Bangxing Han, Yang Zhou*, Cloning, purification and enzymatic characterization of recombinant human superoxide dismutase 1 (SOD1) expressed in Escherichia coli, Acta Biochimica Polonica, 2018, (通讯作者)

   (12) Hongxing Shen, Wen Zhang, Hua Wang, Yang Zhou*, Shihe Shao*, Identification of recombination between Muscovy duck parvovirus and goose parvovirus structural protein genes, Arch Virol, 2015, 160 (10): 2617-2621 (通讯作者)

    (13) 蒋廷亚,袁少飞,马媛媛,闫丹丹,袁平,谢文茜,施海峰,周阳*,自闭症相关拷贝数变异检测及临床意义解读研究进展,中华医学杂志,2016,96(11): 905~908 (通讯作者)

    (14)Qiang Wang, Xiaoli Ju, Yang Zhou, Keping Chen*, Necroptotic cells release find-me signal and are engulfed without proinflammatory cytokine production, In Vitro Cell Dev Biol Anim, , 51(10): 1033-1039

    (15) Li Gao*, Qin Li, Raoqi Li, Lirong Yan, Yang Zhou, Keping Chen, Haixia Shi, Highly sensitive detection for proteins using graphene oxide-aptamer based sensors, Nanoscale, 2015, 7(25): 10903-10907

    (16) Raoqi Li, Qin Li, Yang Zhou, Keping Chen, Chunxia. Zhang, Liang Chen, Li Gao*, Jingjie Cui, Graphene-based DNA sensors, Materials Technology, 2015, 30(B3): B163-B166

    (17) Li Gao*, Chaoqun Lian, Yang Zhou, Lirong Yan, Qin Li, Chunxia Zhang, Liang Chen, Keping Chen, Graphene oxide-DNA based sensors, Biosensors Bioelectronics, 2014, 15(60): 22-29

    (18) Chaoqun Lian, Yang Zhou, Fan Feng, Liang Chen, Qi Tang, Qin Yao, Keping Chen*, Surface display of human growth hormone on Bacillus subtilis spores for oral administration, Curr Microbiol, 2014, 68(4): 463-471

     (19) Fan Feng, Liang Chen, Chaoqun Lian, Hengchuan Xia, Yang Zhou, Qin Yao, Keping Chen*, Comparative proteomic analysis reveals the suppressive effects of dietary high glucose on the midgut growth of silkworm, J Proteomics, 2014, 28(108): 124-32

      (20) Li Gao*, Jingjie Cui, Yang Zhou, Liang Chen, Chunxia Zhang, Keping Chen, Chaoqun Lian, Lihua Li, Hong Li, Ji nke Liang. A strategy for sequencing based on rolling-circle amplification on a Microarray, Journal of Biomedical Nanotechnology, 2013, 9(4): 615-620

      (21) Hongxing Shen, Yang Zhou, Wen Zhang, Bin Nin, Hua Wang, Xiaochun Wang, Shihe Shao, Huiqing Chen, Zhongjian Guo, Qin Yao, Keping Chen*, Characterization of BmNPV with a knockout of Bm17, Cytotechnology, 2012, 64(6): 711-718

      (22) Nan Wang, Haifeng Shi, Qin Yao, Yang Zhou, Lequn Kang, Chen H, Keping Chen*, Cloning, expression and characterization of alcohol dehydrogenases in the silkworm Bombyx mori, Genet Mol Biol, 2011, 34(2): 240-243

   【会议学术报告】

1. Yang Zhou, Haifeng Shi, Iron induced proteomic changes in silkworm Bombyx mori, 17th international biophysics congress, Beijing, China Oct. 30-Nov. 3, 2011,

2. Yang Zhou, Yawen Cheng, Tingya Chiang, Gongda Yang, Xiaofeng Li, Fengbo Zeng, Xiaocheng Wang, Jun Ge, Lei Liu. Noninvasive Detection of Infection and Rejection in Renal Transplant Patients, 2018 American Transplant Congress (ATC) at the Washington State Convention Center, Seattle, WA, June 2–6th, 2018

3. 刘磊, 蒋廷亚, 唐笑天, 杨功达, 黎小锋, 陈雅文, 周阳*, 游离DNA在器官肾移植急性排斥和感染中的应用, 2017年器官移植学年会, 中国, 武汉, 2017.10.27-10.29

  【专利】

(1) 周阳,施海峰,高力,陈亮,刘海涛,张春霞,陈克平,一种家蚕核型多角体病毒免疫胶体金试纸条及检测方法,授权,2016.08.24,201410647226.0

(2) 周阳,施海峰,高力,陈亮,刘海涛,张春霞,陈克平,一种家蚕核型多角体病毒快速检测试剂盒及检测方法,授权,2017.3,201410646786.4

(3) 周阳,袁少飞,王赟,韩娟,刘倩,施海峰,刘海涛,闫丹丹,高力,一种核壳式磁性高分子纳米颗粒在酶的固定化中的应用. ,201710030807.3

(4) 高力,周阳,陈克平,张春霞,陈亮,连超群,一种DNA甲基化检测试剂盒及其检测方法,2014.10,中国,201210524641.8

(5) 高力,周阳,陈克平,张春霞,陈亮,连超群,一种基于石墨烯传感器检测DNA突变的方法,2015.7,中国,201310224960.1

(6) 杨功达,蒋廷亚,曾丰波,胡秀弟,黎小锋,陈雅文,刘磊,周阳,检测异源cfDNA的SNP分子标记及检测方法、用途,实质审查程序,201710334862.1

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