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高力(硕导)

联系方式 gaoli@ujs.edu.cn


研究经历

2010年,东南大学吴健雄实验室,博士

 

主要研究方向及内容:生物芯片、生物传感器

1. 新型生物芯片的制备及应用

高通量的研究工具——生物芯片,又称蛋白芯片或基因芯片,它们起源于DNA杂交探针技术与半导体工业技术相结合的结晶。该技术系指将大量探针分子固定于支持物上后与带荧光标记的DNA或其他样品分子(例如蛋白,因子或小分子)进行杂交,通过检测每个探针分子的杂交信号强度进而获取样品分子的数量和序列信息。


2. 单分子传感器的构建及高灵敏检测

单分子传感器是当前研究的热点,实现具有1个分子灵敏度,如1根DNA链或1个蛋白质分子在线检测是当前检测研究的终极目标之一,我们制备出单分子传感器,并在生物检测方面初步应用。

 

学生荣誉

2人次获国家奖学金

1人次获省创新计划

1人次获校优秀毕业生

1人次获加拿大硕士联合培养1年

 

发表的论文

(1) Li Gao, Lele Li, Xiaolong Wang, Peiwen Wu, Yang Cao, Bo Liang, Xin Li, Yuanwei Lin, Yi Lu and Xuefeng Guo. Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity. Chemical Science, 2015, 6(4), 24692473.

(2)Li Gao, Qin Li, Raoqi Li, Lirong Yan, Yang Zhou, Keping Chen, Haixia Shi. Highly sensitive detection for proteins using graphene oxide-aptamer based sensors. Nanoscale, 2015, 7, 10903–10907.

(3)LiGao,Chaoqun Lian, Yang Zhou, Lirong Yan, Qin Li, Chunxia Zhang, Liang Chen, Keping Chen. Graphene oxide-DNA based sensors.Biosensors Bioelectronics ,2014, 60, 22–29.

(4) Li Gao, Jingjie Cui, Yang Zhou, Liang Chen, Chunxia Zhang, Keping Chen, Chaoqun Lian, Lihua Li, Hong Li, and Jinke Liang. A strategy for sequencing based on rolling-circle amplification on a Microarray. Journal of Biomedical Nanotechnology, 2013, 9(4), 615–620.

(5) Li Gao, Qin Li, Raoqi Li, Zebin Deng, Brendan Brady, Ni Xia, Guimin Chen,Yang Zhou, Hengchuan Xia, Keping Chen, Haixia Shi. Protein determination using graphene oxide-aptamer modified gold nanoparticles in combination with Tween 80, Analytica Chimica Acta, 2016, 941:80.

(6) Li Gao, Qin Li, Zebin Deng, Brendan Brady, Ni Xia, Yang Zhou, Haixia Shi. Highly sensitive protein detection via covalently linked aptamer to MoS2 and exonuclease-assisted amplification strategy, International Journal of Nanomedicine, 2017 (in press)

(7) Lirong Yan, Haixia Shi, Xiaowei Sui, Zebin Deng,Li Gao*. MoS2-DNA and MoS2 based sensors, RCS Advances, 2017, 7(38), 23573–23582.

(8) Li Gao, Hua Lu, Hong Zhao, Zuhong Lu. An extension-quenching-extension sequencing on a microarray. Talanta, 2010, 81, 418423.

(9) Li Gao, Hua Lu, Zuhong Lu. An efficient strategy for sequencing-by-synthesis. Journal of Nanoscience and Nanotechnology, 2010, 10, 2988–2993.

(10) Li Gao, Zuhong Lu. The removal of fluorescence in DNA sequencing. Biochemical and Biophysical Research Communications, 2009, 387: 421–424.

(11) Xiaolong Wang#, Li Gao#, Bo Liang, Xin Li, and Xuefeng Guo, Revealing the Direct Effect of Individual Intercalations on DNA Conductance toward Single-Molecule Electrical Biodetection,J. Mater. Chem. B, 2015, 3, 5150. (# Co-first authorCover paper)

(12) LijianXu#, Li Gao#, Li Song, Nongyu He. Self-assembly of APTES on glassy carbon electrode and its analytical application. Journal of Nanoscience and Nanotechnology. 2009, 9 (3):1923–1927.(# 共同第一)

(13) Karuppanan Muthsamy Kathir#,Li Gao#, Dakshinamurthy Rajalingam,Anna E. Daily,Sherri Brixey, Huimin Liu,Dan Davis,Paul Adams,Igor Prudovsky,Thallapuranam Krishnaswamy Suresh Kumar. NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I Biochimica et Biophysica Acta - Biomembranes,2010,1798 (2), 297–302.(#共同第一)

(14) Haixia Shi, Qin Li, Raoqi Li, Ti Hu, Lei Yao, Li Gao*. Highly sensitive detection for stimulants using an aptamer functionalized gold nanoparticles. Materials Technology, 2015, 30(3), 178-181.(*通讯作者)

(15) Raoqi Li, Qin Li, Yang Zhou, Keping Chen, Chunxia. Zhang, Liang Chen, Li Gao*, Jingjie Cui. Graphene-based DNA sensors. Materials Technology, 2015, 163-166. (*通讯作者)

 


申请的发明专利

 

1高力等,基于石墨烯氧化物双氨基固定多T序列检测汞离子的方法201710784190.4

2高力,生物芯片和特异性切割位点DNA序列检测汞离子的方法201710784214.6

3高力等,一种基于石墨烯氧化物传感器及其对Hg2+检测的方法,201710230043.2

4高力等,一种基于酶切检测SNP的方法201611222597.X

5高力等,基于酶切循环放大的石墨烯氧化物-DNA传感器的制备方法和在检测凝血上的应用技术,201610844180.0

6高力等,一种基于聚乙醇修饰的传感器及其检测凝血酶的方法,201510045515.8

7高力等,一种基于二硫化钼的传感器及其制备方法和应用,201610113606.5

8高力等,一种基于二硫化钼的传感器检测SNPs的方法201610335958.5

9高力等,一种基于石墨烯氧化物传感器及其制备方法和应用, 201510687206.0

 

 授权的发明专利

 

1高力等, 一种基于石墨烯氧化物芯片对铜离子的检测方法,201410832706.4

2高力等,一种DNA甲基化检测试剂盒及其检测方法,201210524641.8

3高力等,生物芯片上基于微乳液等温扩增的DNA测序方法,201110233837.7

4高力等,一种基于荧光淬灭的核酸测序方法,200710133930.4

5高力等,一种基于石墨烯传感器检测DNA突变的方法,201310224960.1

6高力等,一种基于石墨烯氧化物芯片DNA解旋酶的检测方法,201410832817.5

7高力等,一种石墨烯DNA传感器的制备方法,201310567407.8

 

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