
陆健,男,1977年生,江苏宜兴人,副研究员,硕士生导师。2001年本科毕业于南京大学生化系,获学士学位;2006年获江苏大学生化与分子生物学硕士学位;2009年获江苏大学食品科学与工程博士学位;2011.2-2013.2美国肯塔基大学医学院毒理研究中心博士后;2015.11-2016.11美国北卡罗来纳州立大学化学系访问学者。2001年7月参加工作,历任江苏大学生命科学研究院实习研究员、助理研究员、副研究员;2013年起任江苏大学基础医学与医学技术学院卫生检验系副研究员、医学院预防医学与卫生检验系副研究员。近年来在SCI源期刊发表论文二十余篇,其中第一作者论文10篇,通讯作者11篇,论文他引170多次。共获得发明专利3项。先后主持或作为主要成员参与国家“973”重大专项、国家自然基金面上项目、各类省市级(含人才类)项目11项,负责各类产学研横向合作项目5项,目前在研各类项目5项。 现担任Toxicol Lett,Toxicol Appl Pharmacol,Toxicol Mech Method,Biol Trace Elem Res等国际知名毒理学专业SCI源期刊审稿人; 系美国毒理学会会员、美国金属毒理学会会员、中国毒理学会会员、中国生化与分子生物学会会员、中国环境诱变剂学会会员、江苏省环境诱变剂学会青年理事。先后被评聘为镇江市科技特派员、南京市“321”双创人才、南京市浦口区“653”双创人才。
E-mail:lujian@@mail.ujs.edu.cn或lujian@@ujs.edu.cn(发邮件时请删除一个@)
地址:医学院2号楼1422办公室或3号楼2517实验室
1.无机物分子毒理机制:主要为镉、铬、氟等金属与非金属离子的分子毒理学
2.毒理基因组学:主要为比较基因组学、蛋白组学及生物信息学在分子毒理学
3.癌症化学预防:主要为天然化合物,包括芹菜素、姜黄素、花青素等对癌症
1.Jian Lu*,Zhongping Zhou, Jianzhou Zheng , Zhuyi Zhang, Rongzhu Lu, Hanqing Liu,
Haifeng Shi , Zhigang Tu*.2D-DIGE and MALDI TOF/TOF MS analysis reveals that
small GTPase signaling pathway may play important roles in cadmium induced colon cell
maligant transformation,Toxicol Appl Pharmacol,288(1):106-13,2015(第一作者,通讯作者)
2.Qi Y, Chen Q, Hao F, Wan Z, Guo H,Lu R, Mao L, Du H,Lu J*, Zhang C*.Subtype
distribution of Hepatitis C virus in Jiangsu, China,J Med Virol. doi: 10.1002/jmv.24356,2015(第一通讯作者)
3.Hao W, Fan L, Chen Q, Chen X, Zhang S,Lan K,Lu J*, Zhang C*.Modified Proofreading
PCR for Detection of Point Mutations, Insertions and Deletions Using a ddNTP-Blocked
Primer.PLoS One.27;10(4):e0123468,2015, doi: 10.1371/journal.pone.0123468. eCollection
2.Hanqing Liu,Jian Lu,Ye Hua,Peishan Zhang, Zhiquan Liang, Lingling Ruan, Caixia Lian,
Haifeng Shi, Keping Chen, Zhigang Tu*.Targeting Heat Shock Protein 90 with Ganetespib for
molecularly targeted therapy of gastric cancer.Cell Death Dis,6:e1595,2015
3.Jian Lu*, Zhuyi Zhang, Zhong Ni, Haijun Shen, Zhigang Tu, Hanqing Liu, Rongzhu Lu,
Haifeng Shi. The non-additive contribution of hydroxyl substituents to Akt kinase–apigenin
affinity.Molecular Simulation,DOI:10.1080/08927022.2014.913099,(online),2014,
4.Yuntao F, Chenjia G, Panpan Z, Wenjun Z, Suhua W, Guangwei X, Haifeng S,Jian L, Wanxin
P, Yun F, Cai J, Aschner M, Rongzhu L.Role of autophagy in methylmercury-induced
neurotoxicity in rat primary astrocytes.,Arch Toxicol.2014. [Epub ahead of print]
4.Jian Lu*,Zhuyi Zhang, Zhong Ni, Haijun Shena, Zhigang Tu, Hanqing Liu, Rongzhu Lu.
QM/MM–PB/SA scoring of the interaction strength between Akt kinase and apigenin
5.Poyil Pratheeshkumar, Young-Ok Son, XinWang, Sasidharan Padmaja Divya, Binoy
Joseph,John Andrew Hitron, Lei Wang, Donghern Kim, Yuanqin Yin, RamVinod Roy,
Jian Lu,Zhuo Zhang , Yitao Wang , Xianglin Shi*. Cyanidin-3-glucoside inhibits
UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB
signaling pathways in SKH-1 hairless mice skin.Toxicol Appl Pharmacol,
DOI: 10.1016/j.taap.2014.06.028,(online),2014
6. Hu YG, Lu YZ,Lu J*. Comparative proteomics analysis of tea leaves exposed to subzero
temperature: Molecular mechanism of freeze injury. Int J Agric & Biol Eng, 6(4): 27-34,2013(通讯作者)
7.Yuanqin Yin, Wenqi Li , Young-Ok Son , Lijuan Sun ,Jian Lu, Donghern Kim , Xin Wang,
Hua Yao ,Lei Wang , Poyil Pratheeshkumar , Andrew J. Hitron, Jia Luo, Ning Gao, Xianglin
Shi*, Zhuo Zhang*. Quercitrin protects skin from UVB-induced oxidative damage. Toxicol
Appl Pharmacol,269(1): 61-67,2013
8. Song-Ze Ding *, Yu-Xiu Yang , Xiu-Ling Li , Audrey Michelli-Rivera , Shuang-Yin Han , Lei
Wang ,Poyil Pratheeshkumar , Xin Wang ,Jian Lu, Yuan-Qin Yin , Amit Budhraja , Andrew
J. Hitron. Epithelial–mesenchymal transition during oncogenic transformation induced by
hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial
cells. Toxicol Appl Pharmacol,269(1):61-67,2013
9.Wang X, Mandal AK, Saito H, Pulliam JF, Lee EY, Ke ZJ,Lu J, Ding S, Li L, Shelton BJ,
Tucker T, Evers BM, Zhang Z, Shi X*.Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential
mechanism is ROS-mediated Wnt/β-catenin signaling pathway.Toxicol Appl Pharmacol,
10. Lu J*,Xu Q, Chen H, Li J,Chen K. Comparative proteomics analysis of midgut samples from
Takifugu rubripesexposed to excessive fluoride: initial molecular response to fluorosis.
Toxicol Mech Method, 21(6): 444-452,2011(第一作者,通讯作者)
11.Jian Lu, Jianzhou Zheng,Na ding ,Chiyu Zhang*. Adaptive evolution of vertebrate skeletal
muscle sodium channel. Genet Mol Biol,34(2): 323–328,2011(第一作者)
12.Jian Lu*,Jianzhou Zheng, Haijun Liu ,Jun Li, Huayou Chen, Keping Chen. Protein profiling
analysis of skeletal muscle of a pufferfish,Takifugu rubripes.Mol Biol Rep,37(5): 2141-2147,2010(第一作者,通讯作者)
13.Jian Lu*, Jianzhou Zheng, Haijun Liu, Jun Li, Qinggang Xu, Keping Chen. Proteomics
analysis of liver samples from puffer fishTakifugu rubripesexposed to excessive fluoride: An
insight into molecular response to fluorosis. J Biochem Mol Toxic,24(1): 21 – 28,2010(第
14.Jian Lu*,Huayou Chen; Qinggang Xu; Jianzhou Zheng; Haijun Liu;Jun Li; Keping
Chen. Comparative proteomics of kidney samples from puffer fishtakifugu rubripes
exposed to excessive fluoride: an insight into molecular response to fluorosis.
Toxicol Mech Method, 20(6):345-354,2010(第一作者,通讯作者)
15.Jian Lu*, Qinggang Xu, Jianzhou Zheng, Haijun Liu, Jun Li, and Keping Chen*.Comparative
proteomics analysis of cardiac muscle samples from pufferfishtakifugu rubripesexposed to
excessive fluoride: initial molecular response to fluorosis.Toxicol Mech Method,19(6-7):468–475,2009(第一作者,通讯作者)
16.Jianzhou Zheng,Jian Lu, Haijun Liu, Jun Li, Keping Chen. Sequence and structural analysis
of 4SNc-Tudor domain protein fromtakifugu rubripes. Bioinformation,4 (3): 127-131,2009
17. Huayou Chen, Xiaoli Tan,Jian Lu, Chunxia Zhang,Yi Zhang, Shengli Yang*.
Characterization of ATPase activity of class II chaperonin from thehyperthermophilic
archaeon Pyrococcus furiosus. Biotechnol Lett,31(11): 1753-1758,2009
18.Jian Lu, Haijun Liu, Qin yao, Yong Wang, Keping Chen. An RNA Folding Algorithm Based
on dynamic weighted matching. Journal of Biomathetics (China) 23(4):743-749,2008(第
19.YongJie Wang, Qin Yao, KePing Chen, Yong Wang,Jian Lu, Xu Han. Characterization of
the genome structure ofBombyx moridensovirus (China isolate).Virus Genes35:103–108,
1.芹菜素用于在制备抑制支架蛋白表达及癌细胞转移的药物中的应用陆健、张
竹易、周中平,专利申请号201410378080.4,已公开;2014
2.复合纳米银新生儿护脐带 彭宇竹, 陆健,华联实用新型专利 ,专利号:
CN2868251 ,已授权,2007.2.14;
3.家蚕丝素固定化细胞生产L-天门冬氨酸的工艺 陆健,董英,国家发明专利,
专利号:ZL03131658.1 已授权,2004.10.20。
1. SAHF核心元件BRG1-HP1-H3K9me复合物的鉴定与功能研究,国家自然科学基
金面上项目(No. 31471294),经费80万,在研,第二,2014-2018;
2.中成药的国际标准化研发服务,南京“321”创新创业领军人才优先资助项目
(2013A12001)经费100万,在研,主持,2013-2016;
3.中成药的国际标准化研发服务,浦口区“653” 创新创业领军人才资助专项,
4.营养失衡导致脂代谢紊乱疾病的病理生理学机制与早期干预研究,国家
“973”重大专项(2012CB524900),经费200万,分课题,在研,第二,
5.基于气流扰动的茶园防霜机理及控制策略研究,江苏省自然科学基金
(BK2010326),经费20万,已结题,第二完成人;
6.防治鸡球虫病口服生物制剂的研制及产业化,长三角联合攻关重大项目
(2011C16039),经费60万,已结题,第二完成人;
7.河豚鱼氟中毒相关基因的分析与鉴定,江苏大学高级人才基金No.10JDG087,
8.河豚蛋白质组学初步研究与蛋白数据库建立,江苏省高校自然科学基金
(No.1191330001),经费3万,已结题,第一完成人;