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齐向辉(博导)

【个人简介】

姓名  齐向辉

职称  教授 博导

电话  +86-139****2912

传真  +86-511-88780201

Email  qxh(at)ujs.edu.cn

【学术简介】

学习经历:

2016-2017 美国耶鲁大学,交流;

2015-2016 美国加州大学洛杉矶分校, 访问学者;

2009-2011 南京工业大学 化学工程与技术 博士后;

2003-2006 广西大学亚热带农业生物资源保护与利用国家重点实验室 微生物学 博士;

研究经历:

2016-至今 江苏大学 教授、博导;

2013-2014 江苏省镇江市京口区政府、中储粮镇江基地总经理助理;

2010-2016 江苏大学 副教授;

2007-2010 江苏大学 讲师;

1998-2000 河北省元氏环保局 工程师;

学术社会兼职及荣誉:

担任国际期刊Canadian Journal of Applied Sciences 主编,担任国际期刊International Journal of Food Science and BiotechnologyBiotechnology Frontier编委;担任Protein CellIF=7.6, Crit Rev BiotechnolIF=7.0, J Clean ProdIF=6.4),J Ind Eng ChemIF=5.0),Cancer SciIF=4.8, J Agr Food ChemIF=3.6, LWT-Food Sci TechnolIF=3.7, Microbiol ResIF=3.7, Enzyme Microb TechIF=3.6),Molecular CatalysisIF=2.9),Environ Sci Pollut RIF=2.9, Biotechnol LettAppl Biochem Biotech, J Biosci BioengMol BiotechnolAppl Biol ChemBioResourcesFolia MicrobiolChem PapSCI期刊评审专家,担任高新技术企业、国家重点研发计划/专项评审专家。

【主讲课程】

微生物学、酶工程、基因工程、生化工程等

【指导硕、博士生研究方向】

博士研究生:

1、功能性糖醇的生物合成、制造、功能与应用;2、食品微生物发酵工程、途径工程与生物合成;3、酶工程与生物催化

硕士研究生:

1、高附加值食品与食品添加剂的生物合成、制造、功能与应用;2、食品微生物发酵工程、途径工程与生物合成;3 酶工程与生物催化;4、食品微生物快速检测与评估

【研究领域】

致力于以五碳糖、六碳糖、甘油以及生物质等为原料的功能性糖醇等高附加值食品与食品添加剂、医药等产品的生物合成与制造的基础与应用等方面的研究工作。重点围绕D-阿拉伯糖醇、木糖醇、D-塔格糖、D-阿洛糖、1,3-丙二醇、3-羟基丙酸、2,3-丁二醇等高附加值食品、医药等化学品,开展功能微生物的筛选鉴定与工程菌的开发、新酶发现、关键酶定向进化与理性设计、代谢途径工程改造、微生物组学、生物转化合成、发酵工程与代谢调控、合成途径解析与分子机制等方面的研究;并致力于高附加值食品添加剂、保健食品、医药等相关产品的应用与开发。同时,开展了食源性微生物的快速检测与评估等方面的研究工作。

http://spswxy.ujs.edu.cn/info/1009/4387.htm;   (School of Food and Biological Engineering)

https://www.researchgate.net/profile/Xianghui_Qi; (ResearchGate)

https://www.mendeley.com/profiles/xianghui-qi/; (Mendeley)

【主要论著】

发表论文100余篇。以第一或通讯作者在Renewable and Sustainable Energy ReviewsIF=10.556)、Bioresource TechnologyIF=6.667)、Journal of Cleaner ProductionIF=6.395)、Science BulletinIF=6.277)、Food ChemistryIF=5.339Journal of Agricultural and Food ChemistryIF=3.571等杂志发表SCI/EI论文40余篇,影响因子累计120多分,JCR Q1区论文16篇,10分以上中科院一区论文2篇,6分以上中科院一区论文9篇,Top h-index论文9篇;在国际知名的Springer NatureElsevier等出版社出版英文专著(章节)3部和中文专著(章节)1部。

近年发表的部分代表性论文:

[1] Hossain M. Zabed, Suely Akter, Junhua Yun, Guoyan Zhang, Yufei Zhang, Xianghui Qi*. Biogas from microalgae: Technologies, challenges and opportunities. Renewable & Sustainable Energy Reviews, 2020, 117: 109503. doi: 10.1016/j.rser.2019.109503. (SCIJCR Q1,中科院一区, IF=10.556)

[2] Mostafa E. Elshobary, Atef M. Abo-Shady, Hanan M. Khairy, Dorya Essa, Hossain M. Zabed, Xianghui Qi*. Abd El-Fatah Abomohra. Influence of nutrient supplementation and starvation conditions on the biomass and lipid productivities of Micractinium reisseri grown in wastewater for biodiesel production. Journal of Environmental Management, 2019, 250: 109529. doi:10.1016/j.jenvman.2019, 109529. (SCIJCR Q1,中科院二区, IF=4.865)

[3] XiaLiu#, XianghuiQi#, SongZhu, BoJiang, SongGao, YifengZhang, HonglingWang, ShuminXu, YifeiLiu, YingfengAn. Embedding inulin fructotransferase from Arthrobacter aurescens into novel curdlan-based mesoporous silica microspheres for efficient production of Difructose Anhydride III. Food Chemistry, 2019, 299: 125128. doi:10.1016/j.foodchem.2019.125128. (SCIJCR Q1,中科院一区, IF=5.399)

[4] Hossain M. Zabed, Yufei Zhang, Qi Guo, Junhua Yun, Miaomiao Yang, Guoyan Zhang, Xianghui Qi*. Co-biosynthesis of 3-hydroxypropionic acid and 1,3-propanediol by a newly isolated Lactobacillus reuteri strain during whole cell biotransformation of glycerol, Journal of Cleaner Production, 2019, 226: 432-442. doi:10.1016/j.jclepro.2019.04.071. (SCIJCR Q1,中科院一区, IF=6.395)

[5] Miaomiao Yang, Yingfeng An, Hossain M. Zabed, Qi Guo, Junhua Yun, Guoyan Zhang, Faisal N. Awad, Wenjing Sun, Xianghui Qi*. Random mutagenesis of Clostridium butyricum strain and optimization of biosynthesis process for enhanced production of 1,3-propanediol. Bioresource Technology, 2019, 284: 188-196. doi: 10.1016/j.biortech.2019.03.098. (SCIJCR Q1,中科院一区, IF=6.669)

[6] Zabed, Hossain M., Suely Akter, Junhua Yun, Guoyan Zhang, Faisal N. Awad, Xianghui Qi*, and J. N. Sahu. Recent advances in biological pretreatment of microalgae and lignocellulosic biomass for biofuel production. Renewable & Sustainable Energy Reviews, 2019, 105: 105-128. doi: 10.1016/j.rser.2019.01.048. (SCIJCR Q1,中科院一区, IF=10.556, Top h-index)

[7] Fokum, Ernest, Hossain M. Zabed, Qi Guo, Junhua Yun, Miaomiao Yang, Hao Pang, Yingfeng An, Wen Li, Xianghui Qi*. Metabolic engineering of bacterial strains using CRISPR/Cas9 systems for biosynthesis of value-added products. Food Bioscience. 2019, 28: 125-132. doi: 10.1016/j.fbio.2019.01.003. (SCIJCR Q1,中科院三区, IF=3.22)

[8] Guoyan Zhang, Yingfeng An, H. Zabed, Qi Guo, Jiao Yuan, Wenjing Sun, Xianghui Qi*.  Bacillus subtilis Spore Surface Display Technology: A Review of its Development and Applications. Journal of Microbiology and Biotechnology, 2019, 29: 179-190. doi: 10.4014/jmb.1807.06066. (SCIJCR Q2,中科院四区, IF=1.975)

[9] Qi Guo, H. Zabed, Huanhuan Zhang, Xu Wang, JunhuaYun, Guoyan Zhang, MiaomiaoYang, Wenjing Sun, Xianghui Qi*. Optimization of fermentation medium for a newly isolated yeast strain (Zygosaccharomyces rouxii JM-C46) and evaluation of factors affecting biosynthesis of D-arabitol. LWT-Food Science and Technology, 2019, 99: 319-327. doi:10.1016/j.lwt.2018.09.086. (SCIJCR Q1,中科院二区, IF=3.714)

[10] Wen Li, Zhicheng Zhou, Jiaxiang Huang, Guoyan Zhang, Faisal N. Awad, Radhika Chandankere, Qi Guo*, Xianghui Qi*. Screening and Identification of Lactic Acid Bacteria with D-tagatose Production Capability. Biotechnology Journal International, 2019, 23: 1-6. doi: 10.9734/BJI/2019/v23i230074.

[11] Herui Gao#, Xianghui Qi#, Darren J. Hart, Song Gao, Hongling Wang, Shumin Xu, Yifeng Zhang, Xia Liu, Yifei Liu, Yingfeng An. Three Novel Escherichia coli Vectors for Convenient and Efficient Molecular Biological Manipulations. Journal of Agricultural and Food Chemistry, 2018, 66, 6123−6131. doi: 10.1021/acs.jafc.8b01960. (SCIJCR Q1,中科院一区, IF=3.571)

[12] Huanhuan Zhang, Junhua Yun, H. Zabed, Miaomiao Yang, Guoyan Zhang, Yilin Qi, Qi Guo, Xianghui Qi*. Production of xylitol by expressing xylitol dehydrogenase and alcohol dehydrogenase from Gluconobacter thailandicus and co-biotransformation of whole cells. Bioresource Technology, 2018, 257:223-228. doi: 10.1016/j.biortech.2018.02.095. (SCIJCR Q1,中科院一区, IF=6.669)

[13] Tinashe AM, H. Zabed, Miaomiao Yang, Junhua Yun, Huanhuan Zhang, Xianghui Qi*. Improvement of industrially important microbial strains by genome shuffling: Current status and future prospects. Bioresource Technology, 2018, 257:281-289, doi: 10.1016/j.biortech.2018.02.118. (SCIJCR Q1,中科院一区, IF=6.669)

[14] 杨苗苗,员君华,张欢欢,张国艳,Hossain Zabed齐向辉*. 基于甘油的1,3-丙二醇生物合成的代谢局限及其改造策略. 生物工程学报, 2018, 34(7): 1069-1080. doi: 10.13345/j.cjb.170516. (PubMed)

[15] Miaomiao Yang, Junhua Yun, Huanhuan Zhang, Tinashe A. Magocha, Hossin Zabed, Yanbo Xue, Ernest Fokum, Wenjing Sun, Xianghui Qi*. Genetically Engineered Strains: Application and Advances for 1,3-Propanediol Production from Glycerol, Food Technology and Biotechnology, 2018.56(1): 3-15. doi: 10.17113/ftb.56.01.18.5444. (SCIJCR Q2,中科院三区, IF=1.517)

[16] Junhua Yun, Miaomiao Yang, Tinashe A Magocha, Huanhuan Zhang, Yanbo Xue, Guoyan Zhang, Xianghui Qi*, Wenjing Sun. Production of 1,3-propanediol using a novel 1,3-propanediol dehydrogenase from isolated Clostridium butyricum and co-biotransformation of whole cells. Bioresource Technology, 2018, 247838-843. doi: 10.1016/j.biortech.2017.09.180. (SCIJCR Q1,中科院一区, IF=6.669, Top h-index)

[17] Qi Guo,Yingfeng An, Junhua Yun; Miaomiao Yang, Tinashe A Magocha, Jingfei Zhu, Yanbo Xue, Yilin Qi, Zabed Hossain, Wenjing Sun, Xianghui Qi*. Enhanced D-tagatose production by spore surface-displayed L-arabinose isomerase from isolated Lactobacillus brevis PC16 and biotransformation. Bioresource Technology, 2018,247:940-946. doi10.1016/j.biortech.2017.09.187.  (SCIJCR Q1,中科院一区, IF=6.669, Top h-index)

[18] Xianghui Qi*, Huanhuan Zhang, Tinashe Archbold Magocha, Yingfeng An, Junhua Yun, Miaomiao Yang, Yanbo Xue, Shuhua Liang, Wenjing Sun, Zheng Cao. Improved xylitol production by expressing a novel D-arabitol dehydrogenase from isolated Gluconobacter sp. JX-05 and co-biotransformation of whole cells. Bioresource Technology, 2017, 235: 50-58. doi: 10.1016/j.biortech.2017.03.107. (SCIJCR Q1,中科院一区, IF=6.669, Top h-index)

[19] Song Gao#, Xianghui Qi#, Darren J. Hart, Herui Gao, Yingfeng An, Expression and Characterization of Levansucrase from Clostridium acetobutylicum. Journal of Agricultural and Food Chemistry, 2017, 65 (4), 867-871. doi: 10.1021/acs.jafc.6b05165. (SCIJCR Q1,中科院一区, IF=3.571)

[20] Yilin Qi, Huanhuan Zhang†, Junhua Yun†, Miaomiao Yang, Guoyan Zhang, Yanbo Xue, Xuexia Bai, Xianghui Qi*, Yanqin Liu, Longxian Ran. Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains. American Journal of Bioscience and Bioengineering, 2017,5(5): 104-107. doi: 10.11648/j.bio.20170505.13.

[21] Xianghui Qi*, Jing-Fei Zhu, Jun-Hua Yun, Jing Lin, Yi-Lin Qi, Qi Guo, Hong Xu. Enhanced xylitol production: Expression of xylitol dehydrogenase from Gluconobacter oxydans and mixed culture of resting cell. Journal of Bioscience and Bioengineering, 2016, 122 (3): 257-262. doi: 10.1016/j.jbiosc.2016.02.009. (SCIJCR Q2,中科院三区, IF=2.24, Top h-index)

[22] Xianghui Qi*, Junhua Yun, Yilin Qi, Huanhuan Zhang, Fei Wang, Qi Guo, Zheng Cao. Expression and Characterization of a Novel 1,3-Propanediol Dehydrogenase from Lactobacillus brevis. Applied Biochemistry and Biotechnology, 2016, 179:959-972. doi: 10.1007/s12010-016-2043-6. (SCIJCR Q2,中科院三区, IF=2.14)

[23] Xianghui Qi*, Yan Luo, Xu Wang, Jingfei Zhu, Jing Lin, Huanhuan Zhang, Fang Chen, Wenjing Sun. Enhanced D-arabitol production by Zygosaccharomyces rouxii JM-C46: isolation of strains and process of repeated-batch fermentation. Journal of Industrial Microbiology & Biotechnology, 2015, 42:807-812. doi: 10.1007/s10295-015-1603-z. (SCIJCR Q2,中科院二区, IF=3.103, Top h-index)

[24] Xianghui Qi*, Xu Wang, Jing Lin, Jingfei Zhu, Yan Luo, Wenying Deng, Fei Wang, Wenjing Sun, Jianzong Meng. Microbial and Enzymatic Process for Production of Xylitol from D-glucose. Current Organic Chemistry, 2014, 18(24)3131-3135. doi: 10.2174/138527281824150119095755. (SCIJCR Q2,中科院二区, IF=2.193)

[25] Xianghui Qi*, Wenying Deng, Fei Wang, Qi Guo, Huayou Chen, Liang Wang, Xiang He, Ribo Huang. Molecular Cloning, Co-expression, and Characterization of Glycerol Dehydratase and 1,3-Propanediol Dehydrogenase from Citrobacter freundii. Molecular Biotechnology2013, 54(2):469-474. doi: 10.1007/s12033-012-9585-9. (SCIJCR Q2,中科院四区, IF=2.275)

[26] Xianghui Qi*, Qi Guo, Yuotuo Wei, Hong Xu, Ribo Huang. Enhancement of pH stability and activity of glycerol dehydratase from Klebsiella pneumoniae by rational design. Biotechnology Letters, 2012, 34:339-346. doi: 10.1007/s10529-011-0775-5. (SCIJCR Q2,中科院三区, IF=2.154, Top h-index)

[27] Xianghui Qi, Yunlai Chen, Ke Jiang, Wenpu Zuo, Zhaofei Luo, Yutuo Wei, Liqin Du, Hang Wei, Ribo Huang*, Qishi Du. Saturation-mutagenesis in two positions distant from active site of a Klebsiella pneumoniae glycerol dehydratase identifies some highly active mutants. Journal of Biotechnology, 2009, 144: 43-50. doi: 10.1016/j.jbiotec.2009.06.015.SCIJCR Q2,中科院二区, IF=3.163, Top h-index

论著(章节):

[1] Applications of nano-biotechnology for sustainable water purification. Industrial Applications of Nanomaterials Edited. Elsevier, 2019. doi: 10.1016/B978-0-12-815749-7.00011-6.

[2] Anaerobic digestion of microalgae biomass for methane production, Springer Nature, 2019. doi:10.1007/978-981-13-2264-8_16.

[3] An overview on the application of ligninolytic microorganisms and enzymes for biological pretreatment of biomass, Springer Nature, 2018. doi: 10.1007/978-981-13-1307-3.

[4] 海藻糖—21世纪的新型糖类(Trehalose : a novel sugar in the new century),2010,化学工程出版社

【科研项目】

江苏省六大人才高峰高层次人才;科学中国人2018年度人物环境与轻纺领域提名人;主持国家重点研发计划课题1项,主持国家自然科学基金多项,主持 “863”子课题1项,主持省、市、企业合作课题多项;获批国家级大创项目4项、省级4项、校级多项;获批江苏省研究生创新项目1项。

目前主持或合作主持的科研项目:

[1] 国家重点研发计划课题(2017YFC1600806),食品安全专项,主持;

[2] 国家自然科学基金面上项目(31972042):鲁氏酵母利用葡萄糖发酵合成D-阿拉伯糖醇的分子机制与代谢工程改造,主持;

[3] 国家自然科学基金面上项目(31571806):酪酸梭菌1,3-丙二醇耐受性分子机制研究,主持;

[4] 国家自然科学基金项目(31950410550):Development of robust Lactobacillus reuteri cell factory for glycerol metabolism and biosynthesis of 3-hydroxypropionic acid through duel metabolic routes. 合作主持;

[5] 江苏省六大人才高峰高层次人才(SWYY-018):新型L-阿拉伯糖异构酶的制备与生物合成,主持;

[6] 中国博士后特别资助(2019T120402);新型固定化L-阿拉伯糖异构酶催化剂,外籍博士后合作导师;

[7] 中国博士后基金(2017M621657);L-阿拉伯糖异构酶展示与D-塔格糖的合成,外籍博士后合作导师;

[8] 国家自然科学基金面上项目(31571885):变形假单胞菌2-酮基葡萄糖酸转运蛋白的功能及其调控机制,第二参与;

[9] 市科技开发及转化项目:五碳糖/六碳糖综合利用及开发,主持;

近年结题的主要科研项目:

[1] 国家自然科学基金项目:宏基因组甘油脱水酶的分子催化机制及分子改造研究,主持;

[2] “863”项目子课题:新型固定化酶制备与生物合成,子课题主持;

[3] 国家自然科学基金合作项目: γ-PGA生物合成的代谢工程,校内主持;

[4] 江苏省博士后基金(二等): 新型甘油脱水酶基因的克隆表达及三维结构研究,主持;

[5] 江苏大学高级人才引进项目:甘油脱水酶的功能与结构研究,主持;

[6] 单位委托项目:功能微生物的开发及应用,主持;

[7] 国家“973”项目子任务:芽孢杆菌细胞工厂的基础研究,研究骨干;

[8] “863”项目子课题:高温酸性α-淀粉酶的发酵工业技术,研究骨干;

[9] 国家自然科学基金面上项目:BnMPK4介导的抗菌特异信号反应分子机理,主要参与;

[10] “973”项目子任务:嗜热厌氧细菌代谢改造及其纤维素酶的研究,研究骨干。

【科研成果及奖励】

[1] 2019 2018届江苏省优秀本科毕业论文一等奖(指导教师)(1/1);

[2] 2018 校优秀研究生论文指导教师(1/1);

[3] 2017 2016届江苏省优秀本科毕业论文二等奖(指导教师)(1/1);

[4] 2016 镇江市优秀科技论文二等奖(1/7);

[5] 2015 2014届江苏省优秀本科毕业论文二等奖(指导教师)(1/1);

[6] 20142015年共获研究生国家奖学金3人次;

[7] 2014 镇江市优秀科技论文三等奖(1/5);

[8] 2013 校优秀研究生论文指导教师(1/1)。

【所获专利】

代表性发明专利:

[1] 一种木糖醇基因工程菌及其混合转化生产木糖醇的方法,ZL 201210209060.5

[2] 一种1,3-丙二醇基因工程菌及转化生产1,3-丙二醇的方法, ZL 201410051175.5

[3] 一株产D-阿拉伯糖醇的鲁氏酵母菌株及其应用, 201410337503.8

[4] 一种全细胞混合转化甘油生产1,3-丙二醇的方法 201810005295.X

[5] 一种固定化酶催化剂生物合成D-塔格糖的方法 201711395868.6

【在读硕、博士人数】

Research Scientist:翟彼得(Zabed);

PostDoc:范赛尔(Faisal),若迪卡(Radhika),莫丝塔(Mostafa),安瑞士(Amreesh);游瓦(Yuvaraj),鲍娜(Poorna);

PhD Student:苏本(Saboor),胡克(Ernest),员君华(Cherry),薛莉(Suely),李小兰(Fairy);欧大卫(David);

Postgraduate:张国艳(Iris),袁娇(Teixeira),张宇飞(Fizz),王洋(Alean);黄嘉琦(Bessie),郭昊天(Steve),窦媛(Joanne);

Undergraduate:李雯(Wen Li),黄佳祥(Jiaxiang Huang),周志成(Zhicheng Zhou, 段毅(Yi Duan),宋松林(Songlin Song),王京祎(Jingyi Wang

【已毕业硕、博士人数】

10人:田纳(Tina,就业去向:合肥),杨苗苗(Amy,就业去向:上海),张欢欢(Sunny,就业去向:读博), 员君华(Cherry,就业去向:读博),朱婧斐(Jingfei Zhu,就业去向:中国医科院苏州所),罗艳(Yan Luo,就业去向:广州),王旭(Xu Wang,就业去向:北京/瑞典),林静(Jing Lin,就业去向:北京),王飞(Fei Wang,就业去向:北京),邓文颖(Wing Deng,就业去向:南京)。

【指导本科生人数】

2-6/

【以上资料更新日期】

2019-11-05

 

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