Recently, Lulu Zuo published a research article "Trend of HIV-1 drug resistance in China: a systematic review and meta-analysis of data accumulated over 17 years (2001- 2017) ". Lulu Zuo is a joint graduate student of the Institute of Life Sciences of Jiangsu University and the Shanghai Pasteur Institute of the Chinese Academy of Sciences.

Professor Ujjwal Neogi, an internationally famous expert in the field of HIV prevention and treatment, has published a commentary article on this work, which highly affirmed the important of the work.

HIV/AIDS epidemic still remains a huge global public health threat. By Oct, 2019, the scale-up of antiretroviral therapy (ART) for the treatment of HIV/ AIDS had reached 829,628 individuals, accounting for 86.6% of 958,000 estimated HIV-1 infections in China. The long-term medication and widespread use of antiretroviral medicine will inevitably pose new challenges for HIV-1 drug resistance.This study is a meta-analysis that systematically reviewed the regional and temporal trends of HIV-1 drug resistance among ART-naive and ART-treated adult patients in China. The results show that the overall prevalence of acquired and transmitted (TDR) drug resistances in China, and the national trend of TDR from 2001 to 2017, and report the region-specific prevalence pattern of HIV-1 drug resistance in China. They also report high percentages of one NRTI (M184V/I) and three NNRTI (K103N/S, Y181C/I and G190A/S) mutations in ART-naïve and ART-treated individuals, which confer high-level resistance to 3TC, EFV and/or NVP. The above research results are very important for the clinical treatment of HIV-1/AIDS patients in China.

This collaboratively study was completed by the Institute of Life Sciences of Jiangsu University and the Shanghai Pasteur Institute of the Chinese Academy of Sciences. This work was supported by National Natural Science Foundation of China (Grant No. 81672033 and U1302224.) and Open Research Fund Program of the State Key Laboratory of Virology of China (2019IOV002). The co-supervisors were our associate professor Qinggang Xu and professor Chiyu Zhang of the Shanghai Pasteur Institute of the Chinese Academy of Sciences.

Full text link: https://www.sciencedirect.com/science/article/pii/S2589537019302433

Lulu Zuo