夏恒传
副研究员,硕士生导师, 生物化学与分子生物学,博士
电话:0511-88791923
E-mail:hchxia@ujs.edu.cn
学习与工作简历:
1993-1997, 曲阜师范大学,生物学,学士
1997-2004, 中科院上海生化细胞研究所,生物化学与分子生物学,博士
2004-2008, 美国密歇根大学,博士后,结构生物学,分子细胞生物学
2008-至今,江苏大学,生命科学学院。
研究领域:
主要研究方向是昆虫生物学与昆虫病毒学。
目前主要关注家蚕抗BmNPV的分子机制。家蚕具有重要经济价值,也是鳞翅目昆虫研究的模式生物。家蚕在饲养中经常收到多种病原体的侵染,特别是杆状病毒BmNPV的感染,常常会造成很大的经济损失。我们方向的陈克平研究员在多年研究中发现了高抗BmNPV的家蚕品系,进行了大规模的基因组学、转录组学及蛋白质组学研究,发现了可能参与家蚕抗病毒的多种基因及蛋白。目前我们正在进一步研究这些靶基因及蛋白的分子功能,以寻找能够决定家蚕抗BmNPV的关键基因及蛋白,为优化家蚕的分子育种提供新的靶标。
我们发现一类Suppressors of Cytokine Signaling (SOCSs)蛋白质家族与家蚕抗BmNPV可能存在关系。SOCS能够通过抑制经典的JAK-STAT 和IFN干扰素途径及NFkB途径来调控细胞生理和病理的各种重要分子途径。研究发现许多种类的病毒都能够诱导SOCS来逃避宿主的抗病毒免疫反应,而宿主也与病毒竞争控制SOCS来限制病毒的感染复制。目前的研究主要是在脊椎动物特别是哺乳动物中开展的,在无脊椎动物特别是昆虫中研究还是非常少。我们关注家蚕的SOCS。家蚕SOCS在BmNPV感染复制中的作用是什么?是否也在家蚕抗BmNPV免疫反应中发挥作用?我们正在对这些问题进行研究,以阐明家蚕SOCS的作用机制,特别是在家蚕抗病毒的固有免疫机制中的作用。
研究课题:
1. 江苏大学启动基金(家蚕细胞MVB途径及在杆状病毒BmNPV出芽中的作用机制 ,09JDG005),主持。
2. 江苏省高校自然基金 (家蚕细胞MVB途径及在DNA病毒BmNPV出芽中的作用机制研究,10KJB180001),主持。
3. 国家自然科学基金 (家蚕蛋白BmVps4和BmVta1在MVB途径及杆状病毒BmNPV感染中的作用机制研究,31372259),主持。
4. 微生物技术国家重点实验室开放课题 (铜绿假单胞菌铁载体合成途径关键蛋白质的结构及功能研究,M2008-07),主持。
5. 国家自然基金课题(铜绿假单胞菌铁载体pyoverdine的周质空间合成途径中重要蛋白质的结构及功能研究,31170692),参与。
6. 国家自然基金课题 家蚕β-N-乙酰氨基葡萄糖苷酶2对核型多角体病毒蛋白糖基化的影响 (31101673),参与。
7. 家蚕氨基酸转运蛋白与其抗BmNPV功能的研究 (31301919),参与。
8. 国家转基因重大专项(农业部)(高通量二维电泳-质谱联动技术检测转基因水稻产品),参与。
代表性论文:
1. Xia H, Zhang C, Guo Z, Chen L, Chen K. The JAK-STAT pathway in invertebrates: An emerging battleground for host‒virus warfare. Insect Sci. 2025 Jun 30. doi: 10.1111/1744-7917.70109. (1区,Top期刊)
2. Wang Q, Cui M, Zhang C, Xia A, Wang Q, Liu X, Chen K, Xia H. Cloning of suppressor of cytokine signaling 7 from silkworm (Bombyx mori) and its response to the infection of Bombyx mori nucleopolyhedrovirus. Arch Insect Biochem Physiol. 2024 Jan;115(1):e22065. doi: 10.1002/arch.22065.
3. M Cui, Q Wang, C Zhang, A Xia, Q Wang, X Liu, K Chen, H Xia. Cloning and subcellular localization of silkworm suppressor of cytokine signaling 6 and its expressional changes in response to the infection of Bombyx mori nucleopolyhedrovirus. Invertebrate Survival Journal. 2024,21:9-24
4. Xin Zhang, Qian Wang, Miao Cui, Cong Zhang, Yue Wu, Hengchuan Xia. Molecular identification of suppressor of cytokine signaling 2 (SOCS2) and its response to BmNPV in Bombyx mori (Lepidoptera: Bombycidae). Journal of Asia-Pacific Entomology. 2024, 27(2), 102226. https://doi.org/10.1016/j.aspen.2024.102226
5. Zhang, X.; H. Xia; Q. Wang; M. Cui; C. Zhang; Q. Wang; X. Liu; K. Chen. SOCSs: important regulators of host cell susceptibility or resistance to viral infection. Z Naturforsch C J Biosci. 2023 May 29;78(9-10):327-335. doi: 10.1515/znc-2023-0024.
6. Xiao, R.; Y. Yuan; H. Xia; Q. Ge; L. Chen; F. Zhu; J. Xu; X. Wang; Y. Fan; Q. Wang; Y. Yang; K. Chen. Comparative transcriptome and proteome reveal synergistic functions of differentially expressed genes and proteins implicated in an over-dominant silkworm heterosis of increased silk yield. Insect Mol Biol. 2022, 31, 5, 551-567.
7. Huang Z, Sun Z, Liu J, Ju X, Xia H, Yang Y, Chen K, Wang Q. Insect transient receptor potential vanilloid channels as potential targets of insecticides.Dev Comp Immunol. 2023 Nov;148:104899.
8. Wang, Q.; Z. Sun; S. Ma; X. Liu; H. Xia; K. Chen. Molecular mechanism and potential application of bacterial infection in the silkworm, Bombyx mori. Dev Comp Immunol. 2022, 131, 104381.
9. Wang, Q.; J. Wang; M. Ren; S. Ma; X. Liu; K. Chen; H. Xia. Peptidoglycan recognition protein-S1 acts as a receptor to activate AMP expression through the IMD pathway in the silkworm Bombyx mori. Dev Comp Immunol. 2021, 115, 103903.
2010-2020年:
1. Wang, Q.; M. Ren; X. Liu; H. Xia; K. Chen. Identification and characterization of novel short-type BmPGRP-S4 from the silkworm, Bombyx mori, involved in innate immunity. Z Naturforsch C J Biosci. 2020, 75, 1-2, 13-21.
2. Xia, H.; L. Chen; D. Shao; X. Liu; Q. Wang; F. Zhu; Z. Guo; L. Gao; K. Chen. Vacuolar protein sorting 4 is required for silkworm metamorphosis. Insect Mol Biol. 2019, 28, 5, 728-738.
3. Wang, Q.; M. Ren; X. Liu; H. Xia; K. Chen. Peptidoglycan recognition proteins in insect immunity. Mol Immunol. 2019, 106, 69-76.
4. Yuan, Z.; F. Gao; G. Bai; H. Xia; L. Gu; S. Xu. Crystal structure of PvdO from Pseudomonas aeruginosa. Biochem Biophys Res Commun. 2017, 484, 1, 195-201.
5. Xia, H.; D. Shao; X. Liu; Q. Wang; Y. Zhou; K. Chen. Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development. J Insect Sci. 2017, 17, 3, 1-7.
6. Tang, Q.; P. Wu; Z. Hu; Y. Yang; L. Qiu; H. Liu; S. Zhu; Z. Guo; H. Xia; K. Chen; G. Li. Evidence for the role of BmNPV Bm65 protein in the repair of ultraviolet-induced DNA damage. J Invertebr Pathol. 2017, 149, 82-86.
7. 邵丹丹,夏恒传,陈波,余毛毛,陈克平. 多功能分子机器ESCRT的研究进展. 江苏大学学报(医学版). 2016, 26, 4, 360-366.
8. Han, Y.; H. Xia; Q. Tang; P. Lü; S. Ma; Y. Yang; D. Shao; Q. Ma; K. Chen. The Bombyx mori nucleopolyhedrovirus Bm111 affects virulence but not virus replication. Curr Microbiol. 2014, 69, 1, 56-62.
9. 夏恒传,张春霞,冯凡,袁弋,周阳,刘晓勇,朱克明,姚勤,陈克平. 多囊体生物发生和蛋白质分拣 - ESCRT、Vps4、Ubiquitination一个都不能少. 生物化学与生物物理进展. 2013, 40, 2, 103-117.
10. Xia, H.; C. Zhang; F. Feng; Y. Yuan; X. Liu; K. Zhu; Q. Yao; K. Chen. The multivesicular body pathway: A newly discovered battlefield for gamplay between virus and host. African Journal of Microbiology Research. 2013, 7, 11, 913-920.
11. Lü, P.; H. Xia; L. Gao; Y. Pan; Y. Wang; X. Cheng; H. Lü; F. Lin; L. Chen; Q. Yao; X. Liu; Q. Tang; K. Chen. V-ATPase Is Involved in Silkworm Defense Response against Bombyx mori Nucleopolyhedrovirus. PLoS One. 2013, 8, 6, e64962.
12. Xia, H.; C. Zhang; F. Feng; Y. Yuan; Y. Zhou; X. Liu; K. Zhu; Q. Yao; K. Chen. Molecular cloning, expression and characterization of a novel vacuolar protein sorting 4 gene in silkworm, Bombyx mori. Mol Biol Rep. 2012, 39, 12, 10339-46.
13. Qin, L.; H. Xia; H. Shi; Y. Zhou; L. Chen; Q. Yao; X. Liu; F. Feng; Y. Yuan; K. Chen. Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance to Bombyx mori nuclear polyhedrosis virus. J Proteomics. 2012, 75, 12, 3630-8.
14. Xia, H.; C. Wu; Q. Xu; J. Shi; F. Feng; K. Chen; Q. Yao; Y. Wang; L. Wang. Molecular cloning and characterization of lactate dehydrogenase gene 1 in the silkworm, Bombyx mori. Mol Biol Rep. 2011, 38, 3, 1853-60.
15. Liu, X.; K. Chen; Q. Yao; H. Xia. Proteomic analysis of differentially expressed proteins involved in BmNPV resistance in the fat body of silkworm, Bombyx mori. Z Naturforsch C. 2010, 65, 11-12, 713-8.
2010年以前
1. Pan, Y.; H. Xia; P. Lu; K. Chen; Q. Yao; H. Chen; L. Gao; Y. He; L. Wang. Molecular cloning, expression and characterization of Bmserpin-2 gene from Bombyx mori. Acta Biochim Pol. 2009, 56, 4, 671-7.
2. Xiao, J.; H. Xia; J. Zhou; I.F. Azmi; B.A. Davies; D.J. Katzmann; Z. Xu. Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell. 2008, 14, 1, 37-49. (1区,Top 期刊)
3. Xiao, J.; H. Xia; K. Yoshino-Koh; J. Zhou; Z. Xu. Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol. 2007, 374, 3, 655-70.
4. Xia, H.C.; W.G. Hu; X.X. Yang; F. Li; Z.C. Zhang. Preparation and primary application of monoclonal antibodies against a novel ribosome-inactivating protein Moschatin from pumpkin seeds. Acta Biochim Biophys Sin (Shanghai). 2004, 36, 2, 105-10.
5. Xia, H.C.; F. Li; Z. Li; Z.C. Zhang. Purification and characterization of Moschatin, a novel type I ribosome-inactivating protein from the mature seeds of pumpkin (Cucurbita moschata), and preparation of its immunotoxin against human melanoma cells. Cell Res. 2003, 13, 5, 369-74. (1区,Top 期刊)