【个人简介】

姓名：尚东胜

职称：资格副教授，硕导

E-mail: 1000005579@ujs.edu.cn

【学术简历】

学习经历：

2017.09-2021.06 江苏大学，临床检验诊断学，博士学位。

2014.09-2017.06 江苏大学，生物学，硕士学位。

2010.09-2014.06 北方民族大学，生物工程，学士学位。

工作经历：

2021.07-2024.01 江苏大学，博士后。

2024.05-至今 江苏大学，资格副教授。

【研究方向】

1. 细胞衰老的调控机制研究。

2. SASP因子介导的衰老传递及其在老年性疾病中的作用机制研究。

【科研项目】

1. 国家自然科学基金青年项目 2024.01-2026.12，30万元，主持。

2. 江苏大学高级人才科研启动经费 2024-2027，15万元，主持

3. 江苏省卓越博士后计划项目 2022-2024，30万元，主持。

【主要科研成果】

1. Dongsheng Shang, Danlin Sun, Chunyan Shi, Jun Xu, Mingxiang Shen, Xing Hu, Hanqing Liu* and Zhigang Tu*. Activation of EGFR signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. Aging Cell. 2020, 19(5):e13145.

2. Dongsheng Shang, Tianchu Zhou, Xinying Zhuang, Yanfang Wu, Hanqing Liu* and Zhigang Tu*. Molecular dissection on inhibition of Ras-induced cellular senescence by small t antigen of SV40. Cellular and Molecular Life Sciences. 2022, 79(5):242.

3. Dongsheng Shang, Yin Hong, Wangwang Xie, Zhigang Tu* and Jun Xu*. Interleukin-1β drives cellular senescence of rat astrocytes induced by oligomerized amyloid β peptide and oxidative stress. Frontiers in Neurology. 2020, 11: 929.

4. Dongsheng Shang, Yanfang Wu, Ya Ding, Ziwen Lu, Yanting Shen, Feifei Zhu, Hanqing Liu*, Chunyin Zhu* and Zhigang Tu*. Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation. Clinical and Experimental Pharmacology Physiology, 2018, 45(5): 452-460.

5. Dongsheng Shang, Zhihuan Li, Xiaoli Tan, Hanqing Liu* and Zhigang Tu*. Inhibitory effects and molecular mechanisms of ginsenoside Rg1 on the senescence of hematopoietic stem cells. Fundamental & Clinical Pharmacology. 2023, 37(3):509-517.

6. Dongsheng Shang, Hanqing Liu* and Zhigang Tu*. Pro-inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis. Fundamental & Clinical Pharmacology. 2023, 37(5):928-936.

7. Zhicong zhao, Dongsheng Shang, Lipeng Qiu, Chang Guo, Yanyan Li, Hanqing Liu*, Guoyue Yuan* and Zhigang Tu*. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer. Life Sciences. 2019.12, 238:116973.

8. Caixia Lian, Lingling Ruan, Dongsheng Shang, Yanfang Wu, Yongjin Lu, Peng Lü, Yuhua, Yang, Yajun Wei, Xiaojing Dong, Dewan Ren, Keping Chen, Hanqing Liu and Zhigang Tu*. Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Potent Target for Breast Cancer Therapy. Cancer Biother Radiopharm. 2016.04, 31(3):85-90.

9. Lipeng Qiu, Han Xu, Mengchen Ji, Dongsheng Shang, Ziwen Lu, Yihang Wu, Zhigang Tu and Hanqing Liu*. Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms. Life Sciences. 2019.08, 231:116660.

10. Peng Liu, Ziwen Lu, Yanfang Wu, Dongsheng Shang, Zhicong Zhao, Yanting Shen, Yafei Zhang, Feiei Zhu, Hanqing Liu* and Zhigang Tu*. Cellular Senescence-Inducing Small Molecules for Cancer Treatment. Current Cancer Drug Targets. 2019.01, 19(2):109-119.

11. Zhiquan Liang, Ziwen Lu, Yafei Zhang, Dongsheng Shang, Ruyan Li, Lanlan Liu, Zhicong Zhao, Peishan Zhang, Qiong Lin, Chunlai Feng, Yibang Zhang, Peng Liu,  Zhigang Tu* and Hanqing Liu*. Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy. Current Cancer Drug Targets. 2019, 19(2):109-119.

12. Lingling Ruan, Yanting Shen, Ziwen Lu, Dongsheng Shang, Zhicong zhao, Yongjin Lu, Yanfang Wu, Yafei Zhang, Zhigang Tu* and Hanqing Liu*. Roles of partitioning-defective protein 6 ( Par 6 ) and its complexes in the proliferation, migration and invasion of cancer cells. Clinical and Experimental Pharmacology Physiology, 2017.09, 44(9): 909-913.

13. Chunxiu Lin, Peng Liu, Chaowen Shi, Lipeng Qiu, Dongsheng Shang, Ziwen Lu, Zhigang Tu* and Hanqing Liu*. Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers. Fundamental & Clinical Pharmacology. 2023.04, 37(2):194-214.

14. Peng Liu, Ziwen Lu, Lanlan Liu, Ruyan Li, Zhiquan Liang, Mingxiang Shen, Han Xu, Dewan Ren, Mengchen Ji, Sirui Yuan, Dongsheng Shang, Yibang Zhang, Hanqing Liu* and Zhigang Tu*. NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies. Phytomedicine. 2019.11, 64:152925.

15. Lanlan Liu, Peng Liu, Zhiquan Liang, Ruyan Li, Mingxiang Shen, Han Xu, Dewan Ren, Mengchen Ji, Yuhua Yang, Ziwen Lu, Dongsheng Shang, Yibang Zhang, Hanqing Liu* and Zhigang Tu*. Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer. Anti-cancer Drugs. 2019.07, 30(6):554-561.