个人简介
姓名：顾杰
性别：男
出生年月：1982年11月
职称：副研究员
E-mail: 1000004531@ujs.edu.cn
学术简历
【学习经历】
2001/09-2005/06，扬州大学，生物科学与技术，学士学位
2005/09-2008/06，扬州大学，生物化学与分子生物学，硕士学位
2009/03-2011/02，香港浸会大学，生物学，硕士学位
2011/07-2014/06，香港浸会大学，生物学，博士学位
【工作经历】
2014/07-2015/06，香港浸会大学，生物系，助理研究员
2015/06-2016/08，江苏大学，生命科学研究院，助理研究员
2016/09-至今，江苏大学，生命科学研究院，副研究员
【研究兴趣】
重金属的分子毒理与解毒机制
离子稳态失衡相关疾病
环境污染与临床疾病相关研究
【科研项目】
(1) 镇江舒之源科技有限公司，HX20260263，基于多组学的前列腺/肾癌生物标志物检测与风险预测模型开发，2026-04 至 2029‑03， 5 万元，在研, 主持
(2) 江苏省卫生健康委员会, 重点项目, X20241377, ATP2B2调控的钙离子稳态在脓毒症骨骼肌萎缩中的作用机制及干预效果研究, 2025-01 至 2027-12, 40万元, 在研, 参与
(3) 江苏省科学技术厅,青年基金，BK20210747，谷氨酰胺剂量调控乌鳢水泡病毒负责的机制研究，2021-07至2024-06，20万，已结题，参与
(4) 苏州人人基因科技有限公司，1871330003，游离DNA（cell-free DNA, cfDNA）在肾移植免疫排斥中的应用技术开发，2017-12至2020-12，200万，已结题，参与
(5) 国家自然科学基金委员会,青年基金，31600952，钙离子敏感受体CaSR的激活可减轻镉对肾小管上皮细胞的毒性的分子机理的研究，2017-01至2019-12，20万，已结题，主持
(6) 香港General Research Fund项目，GRF 261610, The Identification of Stanniocalcin-1 Target Cells and the Characterization of the In-Situ Ca2+-Sensing and Transport Mechanisms in Gill Epithelial Cells of Japanese Eels, 2010-2013，HK$986,000，已结题，参与
【近年发表论文】
1) Shi Q, Li Z, Fu H Shi H, Gu J*. The dual role of retinoic acid signaling in clear cell renal cell carcinoma and wilms tumor: A tale of two entities. Biochim Biophys Acta Rev Cancer. 2026;1881(5):189667. 一区
2) Li Z Shi Q, Gu J*, Nanomaterial-modified electrochemical sensors for cadmium ion detection: From food safety to biomedical applications, Microchemical Journal, 2026, 227:118638 二区
3) Huo J, Li K, Shi H, Liu Y*, Gu J*. Cadmium-induced ATP6V0A1 destabilization impairs lysosomal function to disrupt hepatic lipid homeostasis. Biochimica et Biophysica Acta-Molecular And Cell Biology of Lipids. 2026, 159733. 二区
4) Gu J*, Ruan J, Li Z, Fu H, Shi Q, Zhu J, Wu J, Gong X, Shi H, Jiang P*. Cadmium induces ferroptosis in B cells via ATP6V0A1-upregulated lysosomal ferritinophagy: insights from murine transcriptomics and human cellular models. Free Radical Biology and Medicine. 2026, 242:138–14. 一区
5) Gu J*, Ruan J, Guo C, Li Z, Fu H, Xie Y, Xie H, Gong X, Shi H*. Organelles Ca2+ redistribution contributes to cadmium-induced EMT of renal cancer cells through p-cPLA2-mediated arachidonic acid release. Ecotoxicology and Environmental Safety. 2025, 298:118317. 一区
6) Gong X, Guo C, Liu J, Li Z, Ruan J, Tang M, Gu J*, Shi H*. Unraveling cadmium-driven liver inflammation with a focus on arachidonic acid metabolites and TLR4/IkBa/NF-kB pathway. Ecotoxicology and Environmental Safety. 2024, 286:117177. 一区
7) Gu J, Guo C, Ruan J, Li K, Zhou Y, Gong X*, Shi H*. From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death. Apoptosis. 2024, 29(5-6):586-604. 二区
8) Guo C, Ruan J, Li Z, Fu H, Li K, Gong X, Gu X, Gu J*, Shi H*. Cadmium promoted LPS-induced inflammation through TLR4/IκBα/NFκB signaling by increasing ROS-mediated incomplete autophagy. Ecotoxicology and Environmental Safety. 2024, 278:116405. 一区
9) Gu J, Li K, Lin H, Wang Y, Zhou Y, Chen D, Gu X, Shi H*. Cadmium induced immunosuppression through TLR-IκBα-NFκB signaling by promoting autophagic degradation. Ecotoxicology and Environmental Safety. 2023, 259:115017. 一区
10) Li K, Guo C, Ruan J, Ning B, Wong CK, Shi H, Gu J*. Cadmium disrupted ER Ca2+ homeostasis by inhibiting SERCA2 expression and activity to induce apoptosis in renal proximal tubular cells. International Journal of Molecular Sciences. 2023, 24(6):5979. 三区
11) Tuffour A, Adebayiga Kosiba A, Addai Peprah F, Gu J, Zhou Y, Shi H. Cadmium-induced stress: a close look at the relationship between autophagy and apoptosis. Toxicological Sciences. 2023, 194(1):1-12二区
12) Xie W, Gu J, Qin Z, Xie Y. The roles of ferroptosis-related long non-coding RNAs in urologic cancers. Ann. Urol. Oncol. 2023, 6(1): 3-9
13) Chu H, Xie W, Guo C, Shi H, Gu J, Qin Z, Xie Y. Inhibiting stanniocalcin 2 reduces sunitinib resistance of Caki-1 renal cancer cells under hypoxia condition. Ann Med Surg (Lond). 2023, 85(12):5963-5971.
14) Qin Z, Li K, Chu H, Yuan X, Shi H, Gu J, et al. Blocking stanniocalcin 2 reduces sunitinib resistance in clear cell renal cell carcinoma. Neoplasma. 2022, 69(1): 145-154.
15) Qin Z, Li K, Gu J, Xie Y, Yuan X. Long non-coding RNA FAM66C promotes prostate cancer metastasis via jnk-mediated proteasome and lysosomal pathway. Ann. Urol. Oncol. 2022, 5(1): 42-51.
16) Chu H, Li K, Gu J, Xie W, Xie Y, Ma J. Long non-coding RNA INE1 induced autophagy promotes sensitivity of prostate cancer cells to cisplatin. Ann. Urol. Oncol. 2022, 5(2): 89-100.
17) Chu H, Qin Z, Ma J, Xie Y, Shi H, Gu J, Shi B. Calcium-sensing receptor (CaSR)-mediated intracellular communication in cardiovascular diseases. Cells. 2022, 11(19):3075.
18) Gu J, Kong A, Guo C, Liu J, Li K, Ren Z, Zhou Y, Tang M, Shi H, Cadmium perturbed lipid profile and induced liver dysfunction in mice through phosphatidylcholine remodeling and promoting arachidonic acid synthesis and metabolism, Ecotoxicology and Environmental Safety, 2022, 247: 114254. 一区
19) Ning B, Guo C, Kong A, Li K, Xie Y, Shi H, Gu J*. Calcium signaling mediates cell death and crosstalk with autophagy in kidney disease. Cells. 2021 Nov 10(11):3204. 二区
20) Kong A, Zhang Y, Ning B, Li K, Ren Z, Dai S, Chen D, Zhou Y, Gu J*, Shi H*. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca(2+) homeostasis. Chemico-Biological Interactions. 2021, 10:109649. 一区
21) Zhang Y, Li K, Kong A, Zhou Y, Chen D, Gu J, Shi H*. Dysregulation of autophagy acts as a pathogenic mechanism of non-alcoholic fatty liver disease (NAFLD) induced by common environmental pollutants. Ecotoxicology and Environmental Safety. 2021, 217:112256. 一区
22) Sun X, Wang Y, Jiang T, Yuan X, Ren Z, Tuffour A, Liu H, Zhou Y, Gu J, Shi H*. Nephrotoxicity profile of cadmium revealed by proteomics in mouse kidney. Biological Trace Element Research. 2021, 199(5):1929-1940. 三区
23) Tuffour A, Kosiba AA, Zhang Y, Peprah FA, Gu J, Shi H*. Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target. Biochim Biophys Acta Rev Cancer. 2021, 1875(2):188528. 二区
24) Shi H, Sun X, Kong A, Ma H, Xie Y, Cheng D, Wong CKC, Zhou Y, Gu J*. Cadmium induces epithelial-mesenchymal transition and migration of renal cancer cells by increasing PGE2 through a cAMP/PKA-COX2 dependent mechanism. Ecotoxicology and Environmental Safety, 2021, 207:111480. 一区
25) Xie Y, Gu J, Qin Z, Ren Z, Wang Y, Shi H, Chen B*. Long non-coding RNA FAM66C is associated with clinical progression and promotes cell proliferation by inhibiting proteasome pathway in prostate cancer. Cell Biochemistry and Function, 2020, 38(8):1006-1016
26) Liu H, Wang Y, Ren Z, Ji X, Addai PF, Zhang X, Dai S, Zhou Y, Gu J*, Shi H*. Dietary cadmium exposure causes elevation of blood ApoE with triglyceride level in mice. Biometals. 2020, 33(4-5):241-254.
27) Lai KP, Lin X, Tam N, Ho JCH, Wong MKS, Gu J, Chan TF, Tse WKF. Osmotic stress induces gut microbiota community shift in fish. Environ Microbiol. 2020, 22(9):3784-3802.
28) Xie Y, Yuan X, Zhou W, Kosiba AA, Shi H, Gu J, Qin Z. The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression: Review. Life Sciences. 2020, 254:117252.
29) Gu J, Ren Z, Zhao J, Peprah FA, Xie Y, Cheng D, Wang Y, Liu H, Chu Wong CK, Zhou Y, Shi H*. Calcimimetic compound NPS R-467 protects against chronic cadmium-induced mouse kidney injury by restoring autophagy process. Ecotoxicology and Environmental Safety. 2020, 189:110052. 一区
30) Kosiba AA, Wang Y, Chen D, Wong CKC, Gu J, Shi H* The roles of calcium-sensing receptor (CaSR) in heavy metals-induced nephrotoxicity. Life Sciences. 2020, 242:117183.
更新于2026年10月
