
马毅,博士/硕士生导师
邮箱: yima@ujs.edu.cn
地址:江苏大学生物科学与技术学院(微生物/合成生物学方向,耒耜大楼F421)
邮编:212013
【教育及工作经历】
2023.08--至今 江苏大学,微生物学(合成生物学领域),教师
2019.09--2023.06 扬州大学/墨尔本大学(澳大利亚),动物营养学,联合培养博士
2017.09--2019.06 石河子大学,动物营养学,硕士
2013.09--2017.06 石河子大学,动物科学,学士
【研究方向】
(1)农业废弃物资源化与高附加值利用技术
面向多类型农业有机废弃物,围绕其组分结构解析与生物转化机制,开展高效资源化利用与功能转化研究,构建稳定可控的高附加值生物转化路径。
(2)合成生物学驱动的代谢工程与微生物细胞工厂构建
通过代谢网络重构与辅因子调控优化,实现农业废弃物碳流与还原力的定向分配,提升目标产物合成效率。
(3)工业酶工程与生物催化体系构建
开发面向复杂底物体系的高效酶元件与级联催化系统,实现农业副产物的结构解聚与功能性转化。
【社会服务】
担任Frontiers in immunology客座编辑; Biotechnology Advances、Animal、Journal of Dairy Scicence 、Journal of Dairy Research、Frontiers等SCI期刊审稿人。
【主要承担项目】
1.《硫胺素对 SARA 山羊乳腺炎症的调控功能及机制研究》(江苏省青年基金:BK20240840),省拨20万,2024.09~2027.08,在研;
2.《工程化植物乳杆菌L-赖氨酸代谢途径的构建及其在动物肠道内源性合成的研究》(高校联合基金,HLFD202502),10万,2025.05~2027.05,在研;
3. 《L-赖氨酸代谢途径的优化及转录调控遗传元件开发》(省部级联合项目),13万,2026.05~2029.05,在研;
【主要代表性论著;H-index= 13,总引用>500】
1. Xu, J., Chen, X., Ma, Yi., Ren, J., Xu, G., Zhang, P., & Wu, S. Rumen Mycobiome Thiamine Metabolism Contributes to Subacute Rumen Acidosis Tolerance in Goats Through Enhancing Epithelial Cell Proliferation via IGFBP2/IGF1 Axis Activation. Exploration, 2026, 70142.(共同一作,中科院一区,IF=22.5);
2. Ma, Yi., Zhang, J., Chen, C., Wang, M., Li, H., Deng, Y., & Guo, Z. Thiamine ameliorates subacute ruminal acidosis–induced mastitis in goats and is associated with modulation of the NF-κB/NLRP3/CLOCK axis and rumen microbial homeostasis. Journal of Dairy Science, 2026,5:5112-5129.(第一作者,中科院一区,IF=4.4);
3. Ma, Yi., Gao, X., Elsabagh, M., Feng, Y., Chen, Y., Cheng, L., & Liu, F. (2025). Anti-Inflammatory potential of lactic acid bacteria for dairy cows during the periparturient period. Animal Feed Science and Technology, 321, 116234.(第一作者,中科院二区,IF=2.7);
4. Ma, Yi., Yang, P., Li, P., Elsabagh, M., Cheng, L., Chen, H., and Xu, M. Dietary thiamine supplementation modulates ruminal microbiota and partly restores lactation performance in lactating Hu ewes under heat-stress conditions. Animal Feed Science and Technology, 2024, 318, 116119.(第一作者,中科院二区,IF=2.7);
5. Ma, Yi., Cheng, L., Gao, X., Elsabagh, M., Feng, Y., Li, Z., and Liu, F. Melatonin modulates lipopolysaccharides-induced inflammatory response and maintains circadian rhythm associated with histone H3 acetylation in bovine mammary epithelial cells. Journal of Functional Foods, 2024, 116, 106156.(第一作者,中科院二区Top,IF=5.6);
6. Ma, Yi., Wang, C., Elmhadi, M., Zhang, H., Liu, F., Gao, X., and Wang, H. R. Dietary supplementation of thiamine enhances colonic integrity and modulates mucosal inflammation injury in goats challenged by lipopolysaccharide and low pH. British Journal of Nutrition, 2022, 128(11), 2147-2157. (第一作者,中科院三区,IF=4.125);
7. Ma, Yi., Elmhadi, M., Wang, C., Li, Z., Zhang, H., He, B., and Wang, H. R. Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFκB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats. Antioxidants, 2022, 11(10), 2048. (第一作者,中科院二区Top,IF=7.675);
8. Ma, Yi., Wang, C., Elmhadi, M., Zhang, H., Han, Y., Shen, B., and Wang, H. R. Thiamine ameliorates metabolic disorders induced by a long-term high-concentrate diet and promotes rumen epithelial development in goats. Journal of Dairy Science, 2021, 104(11), 11522-11536.(第一作者,中科院一区,IF=4.4);
9. Ma, Yi., Wang, C., Zhang, H., Yu, L., Dong, L., Gong, D., and Wang, H. Illumina sequencing and metabolomics analysis reveal thiamine modulation of ruminal microbiota and metabolome characteristics in goats fed a high-concentrate diet. Frontiers in Microbiology, 2021, 12, 653283. (第一作者,中科院一区,IF=6.064);
10. Ma, Yi., Elmhadi, M., Wang, C., Zhang, H., and Wang, H. R. Dietary supplementation of thiamine down-regulates the expression of mitophagy and endoplasmic reticulum stress-related genes in the rumen epithelium of goats during high-concentrate diet feeding. Italian Journal of Animal Science, 2021, 20(1), 2220-2231. (第一作者,中科院三区,IF=2.552)
【研究生招生】
本课题组长期招收硕士研究生,科研经费稳定充裕,可保障实验条件及科研劳务支持。
在读期间提供稳定科研及成果支撑,助力学生申请学业奖学金(特等奖学金1.2万元,前10%;一等奖学金1万元,前20%;二等奖学金8000元,前50%)及国家奖学金(2万元)。
课题组科研氛围开放,注重独立科研能力培养与全过程训练,学习与科研安排相对灵活。优秀学生可推荐至“双一流”、985/211等高校继续攻读博士学位。