马毅，博士，硕士生导师

邮箱: yima@ujs.edu.cn

地址：江苏省镇江市学府路301号，江苏大学，生命科学学院

邮编：212013

【教育及工作经历】

2023.08--至今 江苏大学，微生物学，教师

2022.05--2023.05 澳大利亚 墨尔本大学，动物营养学，博士联合培养

2019.09--2023.06 扬州大学，动物营养学，博士学位

2017.09--2019.06 石河子大学，动物营养学，硕士学位

2013.09--2017.06 石河子大学，动物科学，学士学位

【研究方向】

1. 反刍动物消化道健康与营养代谢调控

2. 微生物定向改造及其对动物肠道健康调控机制研究

【社会服务】

担任Animal、Journal of Dairy Research、Frontiers in Veterinary Science、Frontiers in immunology等国际期刊（SCI）审稿人。

【承担及参与项目】

1. 《硫胺素对 SARA 山羊乳腺炎症的调控功能及机制研究》（江苏省青年基金：BK20240840），省拨20万，2024.09~2027.08，主持，在研。

2. 《秸秆废碳高效转化生物饲料关键技术研究及应用》（镇江市科技项目：CN2024001），市拨15万，2024.09~2027.08，参与，在研。

3. 《农业废弃碳源高效转化蛋白饲料关键技术集成及产业化》（省重点研发项目：BE2023399），省拨500万，2023.04~2027.03，参与，在研。

4. 《基于CCpA蛋白调控山羊瘤胃牛链球菌对乳酸代谢的分子机制》（国自然面上：31872988），参与，结题。

5. 《反刍动物瘤胃中乳酸生成和代谢机制及其与瘤胃酸中毒的关系》（国自然面上：31572429）参与，结题。

【主要代表性论著】

1. Ma, Yi., Yang, P., Li, P., Elsabagh, M., Cheng, L., Chen, H., and Xu, M. Dietary thiamine supplementation modulates ruminal microbiota and partly restores lactation performance in lactating Hu ewes under heat-stress conditions. Animal Feed Science and Technology, 2024, 318, 116119.

2. Ma, Yi., Cheng, L., Gao, X., Elsabagh, M., Feng, Y., Li, Z., and Liu, F. Melatonin modulates lipopolysaccharides-induced inflammatory response and maintains circadian rhythm associated with histone H3 acetylation in bovine mammary epithelial cells. Journal of Functional Foods, 2024, 116, 106156.

3. Ma, Yi., Wang, C., Elmhadi, M., Zhang, H., Liu, F., Gao, X., and Wang, H. R. Dietary supplementation of thiamine enhances colonic integrity and modulates mucosal inflammation injury in goats challenged by lipopolysaccharide and low pH. British Journal of Nutrition, 2022, 128(11), 2147-2157.

4. Ma, Yi., Elmhadi, M., Wang, C., Li, Z., Zhang, H., He, B., and Wang, H. R. Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFκB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats. Antioxidants, 2022, 11(10), 2048.

5. Ma, Yi., Wang, C., Elmhadi, M., Zhang, H., Han, Y., Shen, B., and Wang, H. R. Thiamine ameliorates metabolic disorders induced by a long-term high-concentrate diet and promotes rumen epithelial development in goats. Journal of Dairy Science, 2021, 104(11), 11522-11536.

6. Ma, Yi., Wang, C., Zhang, H., Yu, L., Dong, L., Gong, D., and Wang, H. Illumina sequencing and metabolomics analysis reveal thiamine modulation of ruminal microbiota and metabolome characteristics in goats fed a high-concentrate diet. Frontiers in Microbiology, 2021, 12, 653283.

7. Ma, Yi., Elmhadi, M., Wang, C., Zhang, H., and Wang, H. R. Dietary supplementation of thiamine down-regulates the expression of mitophagy and endoplasmic reticulum stress-related genes in the rumen epithelium of goats during high-concentrate diet feeding. Italian Journal of Animal Science, 2021, 20(1), 2220-2231.

8. Zhang, H., Ma, Yi., Wang, M., Elsabagh, M., Loor, J. J., & Wang, H. Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction. Food & Function, 2020, 11(5), 4456-4470.

9. Zhang, H., Yan, A., Liu, X., Ma, Yi., Zhao, F., Wang, M., and Wang, H. R. Melatonin ameliorates ochratoxin A induced liver inflammation, oxidative stress and mitophagy in mice involving in intestinal microbiota and restoring the intestinal barrier function. Journal of Hazardous Materials, 2021, 407, 124489.