【个人简介】

姓名：石超文

职称：副研究员

E-mail：cwshi@ujs.edu.cn

【学术简历】

学习经历

2007.09-2011.06；西北师范大学，生物科学专业，理学学士。

2011.09-2016.06；南京大学，生命科学学院，硕博连读，生物学博士。

工作经历

2016.10-2018.11 美国 Penn State University Hershey Medical Center 病理生理系，博士后。

2019.09-2020.07 江苏大学，生命科学学院，资格副研究员

2020.08-至今    江苏大学，生命科学学院，副研究员

【研究方向】

调控干细胞分化以及细胞信号通路在纤维化疾病的发生发展过程中作用机制的研究。

【科研项目】

1.江苏省基础研究计划(自然科学基金)青年基金项目，2020/07-2023/07，在研，主持。

2.江苏省双创博士，2021.01-2022.12，在研，主持。

【科研成果】

1.Wang C, Cao H, Gu S, Shi C, Chen X, Han X. Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells. Differentiation; research in biological diversity. 2020;112:10-6.

2.Lin L*, Shi C*, Sun Z, Le N, Abe J, Hu K. The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk. The Journal of biological chemistry. 2019;294(25):9901-10.

3.Xiang Chen, Chaowen Shi, Honghui Cao, Ling Chen, Jiwei hou, Zou Xiang, Hu, Kebin, Xiaodong Han. (2018). The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death & Disease. 2018, 9. 10.1038/s41419-018-(1)0692-9.

4.Chen X, Chaowen Shi, Wang C, Liu W, Chu Y, Xiang Z, Hu K, Dong P, Han X. The role of mir-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Scientific reports 2017; 7:40958.

5.Chaowen Shi*, Cao X*, Chen X, Sun Z, Xiang Z, Zhao H, Qian W, Han X. 2015. Intracellular surface-enhanced Raman scattering probes based on TAT peptide-conjugated Au nanostars for distinguishing the differentiation of lung resident mesenchymal stem cells. Biomaterials 58:10-25.

6.Chaowen Shi, Tengfei Lv, Zou Xiang, Zhaorui Sun, Weiping Qian and Xiaodong Han. Role of Wnt/β-catenin signaling in epithelial differentiation of lung resident mesenchymal stem cells. Journal of cellular biochemistry.2014. DOI: 10.1002/jcb.25069.

7.Chen, X.*, Chaowen Shi*, et al., Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2. Experimental and molecular pathology, 2016.

8.Xiaowei Cao, Chaowen Shi, Wenbo Lu, Hang Zhao, Xiaodong Han, Weiping Qian. Surface Enhanced Raman Scattering Probes Based on Antibody Conjugated Au Nanostars for Distinguishing Lung Cancer Cells from Normal Cells. Journal of Nanoscience and Nanotechnology 2016. 16. 12161-12171. 10.1166/jnn.2016.12971.

9.Sun, F., Mao, P., Wang, C., Chaowen Shi, Nie, R., Han, N., & Han, X. (2016). Cytotoxic Effects of One-step Self-etching Dental Adhesives on Human Periodontal Ligament Fibroblasts In Vitro. The journal of adhesive dentistry. 18. 10.3290/j.jad.a35906.

10.Xiaowei Cao, Xiang Chen, Mingyue Zhang, Wenbo Lu, Chaowen Shi, Li Li, Jian Dong, Xiaodong Han, Weiping Qian. (2016). Process characterization of epithelial-mesenchymal transition in alveolar epithelial type II cells using surface-enhanced Raman scattering spectroscopy. RSC Adv. 6. 10.1039/C5RA17022B.

11.Cao X, Chen X, Chaowen Shi, Zhang M, Lu W, Li L, Dong J, Han X, Qian W. 2016. Process characterization of epithelial-mesenchymal transition in alveolar epithelial type II cells using surface-enhanced Raman scattering spectroscopy. Rsc Advances 6:14321-14328.

12.Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie and Xiaodong Han. Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis. International Journal of Molecular Medicine. 2014 May;33(5):1097-109.

13.Wang C, Dai J, Sun Z, Chaowen Shi, Cao H, Chen X, Gu S, Li Z, Qian W, Han X. 2015. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Experimental cell research 331:115-22.