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December 4, 2019
Tu Zhigang

Curriculum Vitae

  Personal Information

  Name:Zhigang Tu
  Date of Birth: 1978.08
  Job Title:Professor (Tenure-track)


1997.09-2001.06                 BS. School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
2001.09-2004.06                M.S. School of Life Sciences, Nanjing University, Nanjing, China.
2004.08-2008.10             Ph.D. Chemical Biology & Biomedical Engineering Department, Stevens Institute of Technology, NJ, U.S.A.
Professional experience
2008.11-2012.03    Fox Chase Cancer Center, postdoctoral fellow.
2012.04-2013.10    The Wistar Institute, associate staff scientist.
2013.10-                 Institute of Life Sciences, Jiangsu University, Professor (Tenure-track).
Research Interests
1.  To investigate function of BRG1 in oncogene-induced premature senescence.
2.  Studied the effects of the oncogenic Ras on BRCA-1 protein and their biological consequence.
3 .  Designed three series of lytic peptides with high anti-cancer selectivities.
Selected Publications:
1. Tu Z, Aird KM, Zhang R*. Chromatin remodeling, BRCA1, SAHF and cellular senescence. Cell Cycle. 2013;12(11):1653-4
2. Tu Z, Zhuang X, Yao YG, Zhang R*. BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol. 2013;33(9):1819-29.
3. Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL*. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012;120(18):3764-73.
4. Kharidia R, Tu Z, Chen L, Liang JF*. Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. Arch Microbiol. 2012;194(9):769-78. (Co-First author).
5. Tu Z, Aird KM, Zhang R*. RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads. Small GTPases. 2012;3(3):163-7. 5.
6. Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R*. Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence. Dev Cell. 2011;21(6):1077-91.
7. Chen L, Tu Z, Voloshchuk N, Liang JF*. Lytic peptides with improved stability and selectivity designed for cancer treatment. J Pharm Sci. 2012; 101(4):1508-17.
8. Zhigang Tu, Albert Young, Christopher Murphy and Jun F. Liang*. The pH sensitivity of histidine-containing lytic peptides. Journal of peptide science. 2009;(11):790-5.
9. Zhigang Tu, Melanie Volk, Khushali Shah, Kevin Clerkin and Jun F. Liang *. Constructing bioactive peptides with pH-dependent activities. Peptides. 2009, 30: 1523-1528.
10. Agresti C, Tu Z, Ng C, Yang Y, Liang JF*. Specific interactions between diphenhydramine and alpha-helical poly(glutamic acid) - A new ion-pairing complex for taste masking and pH-controlled diphenhydramine release. Eur J Pharm Biopharm. 2008, 70: 226-233.