Title: Cryo-electron microscopy and high resolution microtubule structures
Speaker: Professor Rui Zhang
Time: July 1st, 15：00
Place: Classroom 604 of Institute of Life Sciences
Sponsoring Agency: Institute of Life Sciences
Introduction of the Lecturer: Zhang Rui is an assistant professor at University of Washington. Its research interests are cryo electron microscopy. Graduated from Nanjing University in 2005, received a bachelor''''s degree; then in 2010 at the Baylor College of Medicine (Baylor College of Medicine) received a doctorate. From 2010 to 2016 at the University of California at Berkeley, Laurence Berkeley National Laboratory (Lawrence Berkeley National Laboratory, LBNL) and the Howard Hughes Medical Institute (Howard Hughes Medical Institute, HHMI) postdoctoral research, hyperfine structure of the main research direction for the application of single particle cryo electron microscopy analysis of biological macromolecules; now served as assistant professor at the University of Washington. He was awarded the national outstanding student scholarship in 2009. And successively in Cell, Science, EMBO J, Proc Natl Acad USA and other international famous journal published several research papers.
Lecture Content:In recent years, single particle cryo electron microscopy is rapidly replacing X optical crystallography becomes the main research means of structural biology. China has recently made major scientific breakthroughs in the field of frozen electron microscopy, such as splicing ultra fine structure, frequently published papers in the international top journals.This report, first of all, the paper introduces the basic principles of single grain frozen electron microscopy and history, and introduced its use in analytical microtubules hyperfine structure. Among them, the microtubules is one of the basic components of the cytoskeleton, plays an important role in cell division.
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