Curriculum Vitae

      Job Title: Professor

      Mailing address:  Institute of life science, Jiangsu University 80#, Xuefu Road 301, Zhenjiang , Jiangsu , P.R.China, 212013
      Tel: 15862996375
      Email: shihf@ujs.edu.cn
                                                                                                           

Job qulification    
1994-1998：B.Sc., Department of Biochemistry, NanJing University, PR China
1998-2002：Ph.D, Department of Biochemistry, The Hong Kong University of Science &  Technology, Hong Kong
2006：Small Interfering RNA (SiRNA) and Functional Genomics, FAES training course, NIH
2004-2009：Visiting fellow, Liver Diseases Branch, NIDDK, NIH

Research Interests
Decipher the trafficking of iron and other trace metal elements in cellular plasma. Study the cellular metabolism of trace metal elements and related diseases. Screening iron metabolism related genes. Study the toxicity of iron and other trace metal elements.

Honors & Awards
1996-1998,  People’s scholarship at Nanjing university
1998-2002, Postgraduate studentship at HKUST
2007,  Fellows Award in Recognition of Excellence in Biomedical Research at National Institutes of Health

Publications
1.Shi H., Bencze K., Stemmler T. L., and Philpott C. C., Poly r(C)-Binding Protein 1 is a cytosolic iron chaperone that delivers iron to ferritin. Science 2008 May 30(5880); 320: 1207-10.
2.Yu Z., Chen J., Shi H., Stoeber G., Tsang S. and Xue H., Analysis of GABRB2 association with schizophrenia in German population with DNA sequencing and one-label extension method for SNP genotyping. Clinical Bioch. 2006 Mar. 39(3): 210-8.
3.Xu Z., Fang S., Shi H., Li H., Deng Y., Liao Yi., Wu J., Zheng H., Zhu H., Chen H., Tsang S. and Xue H. (2005) Topology characterization of a benzodiazepine-binding b-rich domain of the GABAA receptor a1 subunit 14 (10), 2622-37.
4.Shi H., Tsang S., Tse M., Xu Z. and Xue H. (2003), Recombinant extracellular domain of the three major subunits of GABAA receptor showcomparable secondary structure and benzodiazepine binding properties. Protein Sci., 12 (11), 2642-6
5.Shi H., Tsang S., Zheng H., Sturgis JN. and Xue H. (2002), Two b-rich structural domain in GABAA receptor a1 subunit with different physical properties: Evidence for multidomain nature of the receptor. Protein Sci., 11(8): 2052-2058.
6.Xue H., Shi H., Tsang S., Zheng H., Savva CG., Sun J. and Holzenburg A. (2001), A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABAA counterpart. J. Mol. Biol., 312(5), 915-920.
7.Hang J., Shi H., Li D., Liao Y., Lian D., Xiao Y. and Xue H. (2000), Ligand binding and structural properties of segments of GABAA receptor a1 subunit overexpressed in Escherichia coli. J. Biol. Chem., 275(25), 18818-18823.
8.Kang L, Shi H, Liu X, Zhang C, Yao Q, Wang Y, Chang C, Shi J, Cao J, Kong J, ChenK., Arginine kinase is highly expressed in a resistant strain of silkworm (Bombyx mori, Lepidoptera): Implication of its role in resistance to Bombyx mori nucleopolyhedrovirus. Comp Biochem Physiol B Biochem Mol Biol. 2011 Mar;158(3):230-4. Epub 2010 Dec 10.
9.Huo J., Shi H., Yao Q., Chen H., Wang L., Chen K.,Cloning and purification of recombinant silkworm dihydrolipoamide dehydrogenase expressed in Escherichia coli, Protein Expr. Purif. 2010 Jan. 72: 95-100.

   

Oral presentation
Shi HF, Philpott, CC Identification of genes facilitating iron storage in ferritin. Poster talk, Trace Element Metabolism: Integrating Basic and Applied Research, Colorado , June 17-22, 2006