Curriculum Vitae
Name: LIU Xiaoguang Ph.D
Title: Professor of Microbiology
Address: Institute of Life Sciences, Jiangsu University, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu China
Research interest:
Global regulatory networks in bacteria, and molecular plant-microbe interactions. Currently focus on the molecular mechanisms of transkingdom signaling transduction involved in the beneficial plant-microbe interactions for improvement of crop yield and resistance to abiotic and biotic stresses using combined approaches such as functional genomics, proteomics and molecular biology, bioinformatics, as well as electronic microscopy, LSCM, LC-MS/MS and MALDI-Tof etc.
Educational Qualifications:
1991-1994: PhD in Forest Pathology, Northeast Forestry University, China. (Thesis: Studies on the epidemiology of poplar bacterial canker)
1988-1991: MSc in Forestry Pathology, Northeast Forestry University, China. (Thesis: Quarantine techniques and host resistance to poplar bacterial canker)
1984-1988: Bachelor in Forestry Protection, Northeast Forestry University, China. (Thesis: Techniques of early detection and the decay pattern of the burn larch logs)
Employment History:
2006-present: Professor, Institute of Life sciences, Jiangsu University, China.
2002-2006: Professor, Department of Plant Pathology, Shandong Agricultural University.
2000-2001: Associated Professor, Department of Plant Pathology, Shandong Agri. Univ.
1996-2000: Associated Professor, Forest College, Agricultural University of Hebei.
1994-1996: Lecturer, Forest College of Hebei, China.
Teaching activities:
v General Plant Pathology, Horticultural Plant Pathology, Ornamental Plant Pathology, Edible Fungi etc. for undergraduates.
v Advanced Plant Pathology, Biocontrol of Plant Diseases, Global Regulatory Network and Signal Transduction in Bacteria and Progress in the Life Sciences for graduate students.
List of Representative Publications: (* corresponding author)
· Liu X*, Wu Y, Chen Y, Xu F, Halliday N, Gao K, Chan KG, Camara M (2016) RpoS differentially affects the general stress response and biofilm formation in the endophytic Serratia plymuthica G3. Res Microbiol. 167:168-177.
· Li J, Yang Y, Dubern J, Li H, Halliday N, Chernin L, Gao K, Cámara M, Liu X* (2015) Regulation of GacA in Pseudomonas chlororaphis strains shows a niche specificity. PLoS ONE. 10(9):e0137553.
· Zhou M, Gao K, Zeng J, Yu X, Wu Y, Ge J, Duan Y, Liu X* (2012) Role of the RNA-binding protein Hfq in Serratia plymuthica. Front Biosci (Elite Ed). 4:1263-75.
· Duan Y, Zou M, Guo S, Ding L, Gao K, Liu X* (2012) Cloning and preliminary identification of SptR, a LuxR-like regulator from Serratia plymuthica. Afri J Mmicrobiol Res. 6(34):6333-6339.
· Liu X*, Jia J, Popat R, Ortori CA, Li J, Diggle SP, Gao K, Cámara M* (2011) Characterisation of two quorum sensing systems in the endophytic Serratia plymuthica strain G3: differential control of motility and biofilm formation according to life-style. BMC Microbiol. 11(1):26.
· Liu X*, Jia J, Atkinson S, Cámara ·M, Gao K, Li H, Cao J (2010) Biocontrol potential of an endophytic Serratia sp. G3 and its mode of action. World J Microbiol Biotech. 26(8):1465-1471.
· Pang Y, Liu X*, Ma Y, Chernin L, Berg G, Gao K (2009) Induction of systemic resistance, root colonisation and biocontrol activities of the rhizospheric strain of Serratia plymuthica are dependent on N-acyl homoserine lactones Euro J Plant Pathol. 124(2):261-268.
· Liu X, Bimerew M, Ma Y, Müller H, Ovadis M, Eberl L, Berg G, Chernin L (2007) Quorum-sensing signaling is required for production of the antibiotic pyrrolnitrin in a rhizospheric biocontrol strain of Serratia plymuthica. FEMS Microbiol Lett. 270(2):299-305.
· Ovadis M#, Liu X#, Gavriel S, Ismailov Z, Chet I, Chernin L (2004) The global regulator genes from biocontrol strain Serratia plymuthica IC1270: cloning, sequencing, and functional studies. J Bacteriol. 186(15):4986-93.( # co-first authors)
· Gao K, Liu X*, Kang Z, Mendgen K (2005) Mycoparasitism of Rhizoctonia solani by endophytic Chaetomium spirale ND35: ultrastructure and cytochemistry of the interaction. J Phytopathol. 153(5):280-290.
· Cao J, Shi F, Liu X, Jia J, Zeng J, Huang G (2011) Genome-wide identification and evolutionary analysis of Arabidopsis Sm genes family. J Biomolecular Structure & Dynamics. 28(4):535-44.
· Cao J, Shi F, Liu X, Zhou M, Huang G. (2010) Phylogenetic analysis and evolution of aromatic amino acid hydroxylase. FEBS lett. 584(23):4775-82.
· Zaĭtseva IuV, Voloshina PV, Liu X, Ovadis MI, Berg G, Chernin LS, Khmel'''''''' IA (2010) Involvement of the global regulators GrrS, RpoS, and SplIR in formation of biofilms in Serratia plymuthica. Russian J Genetics. 46(5):541-545.
· Cao R, Liu X, Gao K, Mendgen K, Kang Z, Gao J, Gai Y, Wang X (2009) Mycoparasitism of endophytic fungi isolated from reed on soilborne phytopathogenic fungi and production of cell wall- degrading enzymes in vitro. Curr Microbiol. 59(6):584-92.
· Gao K, Liu X, Liu Y, Zhu T, Wang S (2003) Potential of Trichoderma harzianum and T. atroviride to control Botryosphaeria berengeriana f. sp. piricola, the cause of apple ring rot. J Phytopathol.; .150(4‐5):271-276.
· Gao K, Liu X. (2001) Antagonism of Trichoderma spp. to the apple tree canker pathogen, Valsa mali. Arch.Phytopathol, 34:21-31.
· Liu X*, Gao K, He B et al. (2003) Effect of time course and carbon source on β-1,3-glucanases from Chaetomium spirale ND35. In: Yang Q. ed. Biological Control and Biotechnology. Harbin, Heilongjiang Science & Technology Press. pp.198-206.
· Gao K, Liu X, Li C et al. (2003) Biocontrol potential of Chaetomium spirale ND35 against canker of apple tree. In: Yang Q ed. Biological Control and Bio-technology Harbin: Heilongjiang Science& Technology Press, pp.132-140.
Book chapters
· Gao K, Liu X* (2011) Ultrastructure and cytochemistry of mycoparasitic interaction in “Prospects and Applications for Plant-Associated Microbes. A Laboratory Manual, PartB: Fungi.” pp. 135- 138 & 266-272. Edited by Pirttila AM and Sorvari S. BBi, Finland. (ISBN 978-952-99302-6-5).
National peer reviewed publications in Chinese
· Yang Y, Gao KX, Wu Y, Liu X*(2016) Indoe-3-acetic acid-mediated cross-kingdom signalling involved in plant-bacteria interaction. Biotechnology Bulletin. 32(8):14-21.
· Xu F, Li J, Duan Y, Liu X* (2014) Quorum sensing signaling networks in bacteria and the potential application. J Biology 31(4) 77-81.
· Chen Y, Wu Y, Liu X* (2014) The regulation and application of acetoin biosynthesis. J Biology 31(5) 76-80.
· Guo S, Liu X* (2013) Bioinformatics analysis of rpoS gene in Serratia plymuthica.J. Jiangsu University (Med ed.) 23(6):485-492.
· Ge J, Ding L, Liu X* (2013) Construction of mutants deficient in splI and spsI in Serratia plymuthica. J Biology 30(1):5-8.
· Yu X, Liu X* (2012) Construction of a prnA mutant deficient in pyrrolnitrin production in Serratia plymuthica. J Biology 29(6):10-13.
· Huang G, Zhou M, Yu X, Wu Y, Gao K, Liu X* (2011) Construction of the small RNA rsmB deletion/insertion mutant in Serratia plymuthica G3. Jiangsu J Agri Sci. 27(5):969-973.
· Zeng J, Liu X*, Guo Z, Jia J, Gao K, Cao J (2010) Construction of RsmA overexpression strain of Serratia plymuthica G3. Jiangsu J Agri Sci. 26(04):888-890.
· Niu X, Zhang H, Bai X, Li W, Liu X, Hu X* (2011) Proteomics analysis of the molecular mechanism of Arabidopsis thaliana responding to bacterial N-3-oxo-hexanoylhomoserine-lactone signals. Plant Divers Resour. 33:389-395.
· Li H, Liu X*, Gao K, Jia J (2009) Cloning of phzIR from the endophytic Pseudomonas sp. G5 and its expression in Escherichia coli. Chin J Biotech, 25(6): 832-839.
· Meng Q, Liu X, Gao K , Kang Z, Wang H (2009) Chaetomium globosum ND35 colonization and influence on enzymes activities in poplar. Acta Phytophylacica Sinica, 36 (1):91-92.
· Qin N, Liu X*, Gao K, Meng Q, Li H, Pang Y (2008) Biocontrol potential of the combination of rhizosphere bacteria and chitosan. J Anhui Agri.Sci. 36 (13):5503 – 5504, 5506.
· Cao R, Liu X, Gao K, Mendgen K, Kang Z (2008) Antagonism of Choiromyces aboriginum Mü1w1c6, an endophytic fungus isolated from common reed against phytopathogenic fungi and its potential for biocontrol. Acta Phytophylacica Sinica.35 (2):107-112.
· Ma Y, Liu X*, Gao K, Qin N, Pang Y, Shi C. (2007) Preliminary study on biocontrol potential of rhizobacterium Serratia plymuthica HRO-C48. J Yunnan Agri Univ.22 (1):49-53.
· Wan H, Liu X, Cao R, Gao K, Song Y (2007) Production of antibiotics by Chaetomium spirale ND35 and the role in biocontrol of plant diseases. Acta Phytophylacica Sinica, 34 (1): 51-56.
· Liu X, Gao K, Kang Z, He B (2007) Systemic resistance induced by biocontrol agents in plants and its biochemical and cytological mechanisms. Chin J Appl Ecol, 18 (8): 1861- 1868.
· Bai F, Liu X*, Li H et al.(2006) Purification and characterization of a chitinase from endophytic Chaetomium spirale ND35. J. Laiyang Agri College.23 (4):268-271.
· Yin J, Liu X, Wan H et al. (2006) A preliminary investigation on biocontrol and growth promotion by Chaetomium spirale ND35. J Laiyang Agri College.23 (4):272-275.
· Guo X, Gao K, Yin J, Bai F, Ma Y, Yu D, Liu X*(2005) Induction and characterization of β-1,3-glucanases from the mycoparasite Chaetomium spirale. Acta Phytopathol Sinica.35 (6):493-503.
· Gao K, Pang Y, Qin H, Liu X*, Kang Z. (2006) Synergistic antifungal activity of antibiotics and hydrolytic enzymes from endophytic Chaetomium spirale ND35. Acta Phytopathol Sinica. 6(4):347-358. (in English)
· Gao K, Liu X*, Friesem D, Chernin L, Shi C (2005) Cell wall degrading enzymes involved in mycoparasitism of the biocontrol agent Chaetomium spirale ND35. Scientia Silvae Sinica. 41(1): 205-210. (in English)
Oral or poster presentations on international conferences/workshops
· Liu X*, Guo S, Wu Y, Dun Y, Heeb S, Cámara M. Transcriptional regulators of the LysR and TyrR family are involved in controlling the biosynthesis of IAA in Serratia plymuthica. the SGM (The Society for General Microbiology) Annual Conference 2014,Liverpool, UK (Oral )
· Wu Y, GuoS, Yu X, Atkinson S, Heeb S, Cámara M, Liu X*. Integrated regulation of pyrrolnitrin production in the endophytic Serratia plymuthica G3. The 10th International Congress of Plant Pathology (ICPP) 2013, China (Poster)
· Wu Y, Gao K, Duan Y, Cámara M, Liu X*. Role of the GGDEF/EAL domain protein PigX in Serratia plymuthica .The 10th ICPP, 2013, China (Poster)
· Liu X*, Gao K, Cámara M. The role of microbial enzymes in the biocontrol of plant diseases. In the Inaugural Symposium on Enzymes & Biocatalysis. 2010, Shanghai, China (Oral)
· Liu X*, Li H, Gao K et al. Characterization of a new endophytic Serratia plymuthica strain G3, with ability to induce systemic resistance to grey mold on bean. In the International Conference on Plant Vascular Biology and Agriculture, 2009, Chongqin, China (Poster).
· Liu X, Müller H, Westendorf C, Bimerew M, Schmidt S, Eberl L, Berg G, Chernin L. Quorum sensing signaling is responsible for biocontrol activity of Serratia plymuthica strains. The 7th “Plant Growth Promoting Rhizobacteria” Workshop. 2006, the Netherlands (Poster).
· Liu X, Ma Y, Bimerew M, Müller H,Ovadis M, Berg G, Eberl L, Chernin L. Pyrrolnitrin antibiotic production is controlled by quorum-sensing network in the biocontrol strain Serratia plymuthica HRO-C48. In the 11th International Symposium on Microbial Ecology. 2006. Vienna, Austria.
· Liu X, de Boer W, Berg G, and Chernin L. N-acyl homoserine lactones produced by strains of Collimonas, Herbaspirillum, and Serratia species, in Proceedings of the ASM Conference on Cell-Cell Communication in Bacteria, 2004, Canada.
· Liu X, Kholmeckaya M, Veselova M, et al. Production of N-acyl homoserine lactone signal molecules in Gram-negative soil-borne and plant-associated bacteria, in Proceedings of the15th IPPC (International Plant Protection Congress), 2004, Beijing.
· Liu X*, Gao K, Wang M et al. Biocontrol activity of the endophytic fungus, Chaetomium spirale strain ND35 against the canker diseases of trees. In Proceedings of the 15th IPPC, 2004, Beijing (Oral).
· Liu X. Detection of N-acyl-homoserine lactone signal molecules and regulation of expression of antifungal factors in biocontrol strains Serratia plymuthica in the Workshop on “Bacteria Genetics•Global Regulationof Gene Expression in Bacteria.” Organized by ICGEB, 2004, Italy (Oral).
Major research projects undertaken as principle investigator:
· EU Marie Curie IIF Fellowship project: Determination of novel molecular cross-signalling mechanisms between bacteria and plants leading to enhanced crop production (PROAGROBAC).
· Functional characterization of the pyrrolnitrin biosynthetic gene clusters from Serratia plymuthica and the underlying regulation mechanisms (NSFC no. 31240046)
· Characterisation of the quorum sensing signaling systems in Serratia plymuthica. *NSFC-RS joint project (no. 30811130218) in collaboration with Prof. Camara M from the University of Nottingham (*NSFC: National Natural Science Foundation of China; RS-Royal Society, UK)
· Characterisation of the second AHL-mediated quorum sensing system in Serratia plymuthica, (NSFC no.30670030)
· Quorum sensing regulation of the interactions of Serratia plymuthica and host plants, Senior Talent Funds of Jiangsu University (no. 07JDG030).
· Quorum sensing regulation of the biocontrol-related traits in plant-associated bacteria”, (NSFC no. 30370954).
· Induction of β-1, 3-glucanases from Chaetomium ND35 and the role in mycoparasitism, (NSFC no. 30100143).
· Antagonistic mechanisms involved in the endophytic Chaetomium ND35 against Rhizoctonia solani”, Science Foundation of Shandong Agricultural University (no. 23013).
· Interactions between the dominant endophytic fungi and the host plant poplar”, Natural Science Foundation of Hebei Province (no.396123).
· Dynamics and biodiversity of endophytic fungi in Populus tomentosa”, Doctorate Foundation of Hebei Province.
Fellowships and Awards:
· 2012-2014 EU Marie Curie International Incoming Fellowship (IIF)
· 2012: The Talent Summit Project of Jiangsu Province
· 2002- 2003: Sino-Israel Government Exchange Fellowship funded by Chinese Scholarship Council (CSC), worked in the group of Profs. Leonid Chernin and Ilan Chet at the Otto Warburg Center for Agricultural biotechnology, the Hebrew University of Jerusalem, Israel.
· 2004: The project “Integrated management of poplar ice nucleation active bacterial canker” was awarded the 2th prize for Sci-Tech progress by Heilongjiang Province.
· 2000: The project “Investigation of the biodiversity of poplar endophytic fungi and screening of the promising biocontrol agents” was awarded the first prize for Sci-Tech progress by Forestry Department of Hebei Province.
· 1996: The project “Techniques of early detection and the decay pattern of the burn larch logs” was awarded the 3rd prize for Sci-Tech progress by Forestry Ministry of China.
