Curriculum Vitae

   Yajing Zhou, Ph.D.

   Professor of Institute of Life Sciences
   Address: 301 XueFu road, Zhenjiang City 212013, Jiangsu Province, P. R. of China
   Email: yajingzhou@ujs.edu.cn
   Websites: http://smkx.ujs.edu.cn/en/faculty/doctor/2010-10-14/31.html

     Dr. Zhou received his Ph.D. degree in 2002 from the East China University of Science &. Technology in                   Shanghai , P. R. China. He completed his post-doctoral work with Dr. Marietta. Y. W. T. Lee at Department of Biochemistry &. Molecular Biology, New York Medical College in USA (2002.12-2005.08). He held the position as a Research Associate Professor at New York Medical College (2005.09-2008.08) and as a Stuff Associate at Department of Pharmacology and Pathology, Columbia University (2009.06-2010.05) in USA before joining the faculty of Jiangsu University, P. R. China. He is currently a Professor of Institute of Life Sciences, Jiangsu University , P. R. China.  
   The long term goal of his research is to exploit the foreign gene expression and protein production using the Silkworm as an insect bioreactor, elucidate the molecular mechanisms that control DNA replication and their functional regulation in mammalian cells and in model organisms.                  

Research Interests
Foreign gene expression and protein production in silkworm bioreactor; DNA replication, repair, and cell cycle regulation.

  Education  
              Jiangsu Polytechnic University   , Organic Synthesis, BS, 1982.
    East China University of Science &.Technology, Biochemical Engineering, MS, 1998.
    East China University of Science &.Technology, Biochemical Engineering, PhD, 2002.

Teaching for Graduate Students
The Advancement of Life Sciences. 2011-.

Research Projects
1.  “Functional Studies on Human DNA Polymerase Delta”, PI, National Natural Science Foundation of China (30970612), 2010.01-2012.12.

2.  “Biochemical Analysis of the Fourth Subunit of Human DNA Polymerase”, PI, Startup Scientific Research Fund from Jiangsu University for Advanced Professionals (09JDG002), 2010.01-2014.12.  

3.  “Biochemical Studies on the Functions of BmNPV DNA polymerase”, Co-PI, National Natural Science Foundation of China (31100118), 2012.01-2014.12.

Selected Publications

1.  Amal A. Rahmeh*, Yajing Zhou*, Bin Xie, Hao Li, Ernest Y. C. Lee, and Marietta Y. W. T. Lee. Phosphorylation of the p68 Subunit of Pol δ Acts as a Molecular Switch to Regulate Its Interaction with PCNA. Biochemistry. 2012, 51(1):416-24 (*joint first author).

2.  Yujue Wang, Qian Zhang, Huiqing Chen, Xiao Li, Weijun Mai, Keping Chen, Sufang Zhang, Ernest Y. C. Lee, Marietta Y.W.T. Lee, Yajing Zhou*. P50, the Small Subunit of DNA Polymerase Delta, Is Required for Mediation of the Interaction of Polymerase Delta Subassemblies with PCNA. PLoS One, 2011, 6(11): e27092 (*Corresponding author).

3.  Yajing Zhou, Huiqing Chen, Xiao Li, Yujue Wang, Keping Chen, Sufang Zhang, Xiao Meng, Ernest Y. C. Lee, Marietta Y.W.T. Lee. Production of Recombinant Human DNA Polymerase Delta in a Bombyx mori Bioreactor. PLoS One, 2011, 6(7): e22224.

4.  Xiao Meng, Yajing Zhou, Ernest Y. C. Lee, Marietta Y. W. T. Lee, and David N. Frick. The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis. Biochemistry-US, 2010, 49, 3545–3554.

5.  Xiao Meng*, Yajing Zhou*, Sufang Zhang, Ernest Y. C. Lee, David N. Frick and Marietta Y. W. T. Lee. DNA damage alters DNA polymerase [delta] to a form that exhibits increased discrimination against modified template bases and mismatched primers. Nucleic Acids Research, 2009, 37(2): 647-657 (*joint first author. Xiao Meng, Ph.D. student).

6.  Yan Gao*, Yajing Zhou*, Bin Xie*, Sufang Zhang, Amal Rahmeh, Hua-shan Huang, Marietta Y. W. T. Lee, and Ernest Y. C. Lee.  Protein Phosphatase-1 Is Targeted to DNA Polymerase δ via an Interaction with the p68 Subunit. Biochemistry-US, 2008, 47 (43): 11367–11376 (*joint first author).

7.  Mocquet V, Lainé JP, Riedl T, Yajing Z, Lee MY, Egly JM.  Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. EMBO J., 2008, 27(1):155-67.

8.  Zhang S, Chea J, Meng X, Zhou Y, Lee EY, Lee MY. PCNA is ubiquitinated by RNF8. Cell Cycle, 2008, 7(21) 3399 - 3404.

9.  Sufang Zhang, Yajing Zhou, Sandra Trusa, Xiao Meng, Ernest Y.C. Lee, and Marietta Y.W.T. Lee. A novel DNA damage response: Rapid degradation of the p12 subunit of DNA polymerase δ, J. Biol. Chem., 2007, 282(21):15330-40.

10. Hao Li*, Bin Xie*, Yajing Zhou*, Amal Rahmeh, Sandra Trusa, Sufang Zhang, Yan Gao, Ernest Y. C. Lee, and Marietta Y. W. T. Lee. Functional roles of p12, the fourth subunit of human DNA polymerase delta. J. Biol. Chem., 2006, 281(21):14748~55 (*joint first author).

11. Hao Li, Bin Xie, Amal Rohmeh, Yajing Zhou and Marietta Y. M. T. Lee. Direct interaction of p21 with p50, the small subunit of human DNA polymerase delta. Cell Cycle, 2006, 5 (4): 428-436.

12. Yajing Zhou, Yongzhu Yi, Zhifang Zhang, Jialu He and Yuanxing Zhang. Cetyltriethylammonium bromide stimulating transcription of Bombyx mori nucleopolyhedrovirus gp64 gene promoter mediated by viral factors. Cytotechnology, 2003, 41(1): 37-44.

13. Yajing Zhou, Yongzhu Yi, Zhifang Zhang, Jialu He, Yuanxing Zhang and Xiangfu Wu. Promoter activities in the baculovirus envelope glycoprotein gp64 gene. Acta Biochimical et Biophysical Sinica. 2003, 35(1), 18-26.

14. Yajing Zhou, Qingli Xiao, Zhifang Zhang, Jialu He and Yuanxing Zhang. Foreign insect hormones stimulating the transcription of ie-1 promoter of Bombyx mori nuclear polyhedrosis virus in vivo and in vitro. Bioscience, Biotechnology, and Biochemistry, 2002, 66(7): 1488-1494.

15. Yajing Zhou, Zhifang Zhang, Jialu He and Yuanxing Zhang. Effects of cetyltriethylammonium bromide on the replication of Bombyx mori nucleopoluhedrovirus. Cytotechnology, 2002, 39(1): 27-35.