Peng Lü (Lyu)                                                                          

Assistant Professor, Master supervisor

Institute of Life Sciences, Jiangsu University

Email: penglu AT ujs.edu.cn (@ replace AT please)

 

 

EDUCATION

Ph.D. in Food Safety (2014)

Jiangsu University, Zhenjiang, P. R. China

M.S. in Biochemistry and Molecular Biology (2009)

Jiangsu University, Zhenjiang, P. R. China

B.S. in Biotechnology (2006)

Jiangsu University, Zhenjiang, P. R. China

RESEARCH INTEREST

New diagnostic methods for virus detection/phage display/interaction between viruses and their host/

PROFESSIONAL EXPERIENCE

12/2014-Present: Assistant Professor (Master supervisor)

Institute of Life Sciences, Jiangsu University

6/2009-9/2011: Research Assistant

Unit of Structural Virology

Institut Pasteur of Shanghai, Chinese Academy of Sciences

PROFESSIONAL & RESEARCH HIGHLIGHTS

@Jiangsu University/Institute of Life Sciences

•         Established phage display platform

Domain antibody screened from commercial Human Domain Antibody Library (purchased from Source Bioscience Inc.) to HBEGF

Selecting antibodies of metabolites by constructing specific ScFv or Fab libraries for diagnosis

•         Established cell suspension culturing platform for protein expression

High 5、Sf21 and Sf9 cells (Baculovirus expression system，BES)/S2 cells/293F/CHO-S cells

•         Interaction between viruses and their host

Resistance gene mapping of Bombyx mori to B. mori nucleopolyhedrovirus (BmNPV, baculovirus) by high-throughput sequencing and gene function using CRISPAR/cas9

Purification of B. mori Bidensovirus (BmBDV) and VLP expressed by BES for studying virus structure and entry

@Institut Pasteur of Shanghai/Unit of Structural Virology

•         Established BES/S2 cell culturing platform for protein structure research

Purification and expression of HRSV, HPIV and EV71 VLPs for structural analysis

FUNDINGS

Key Research & Development Program of Jiangsu Province (BE2017651), Research & Development of new POCT product for detecting the estrone and progesterone through urine using specific Fab antibodies.

Key Research & Development Program of Zhenjiang City (SH2016013), Selecting of Fab antibodies to Estrone and Progesterone metabolites through phage display technology.

National Natural Science Foundation of China (31602008), Studies on molecular mechanism of BmMyosin II in BmNPV-induced host autophagy machinery and the infection of BmNPV.

National Science Foundation of Jiangsu Province (BK20150495), Mechanism study of B. mori carboxylesterase (Bmae45) in the process of BmNPV resistance.

PUBLICATIONS (underlined: the first authors)

- Peer-reviewed Articles:

1. Peng Lü, Yaling He, Feng Lin, Ye Pan, Qian Yu, Zhongjian Guo, Chengjun Li, Huiying Wang, Qin Yao*, Yan Fu* and Keping Chen*, Rapid detection of Bombyx mori bidensovirus by loop-mediated isothermal amplification based lateral flow dipstick assay for field applications, Journal of Invertebrate Pathology, 2019, In Press (available online).

2. Peng Lü, Ye Pan, Yanhua Yang, Feifei Zhu, Chengjun Li, Qin Yao and Keping Chen*, Discovery of anti-viral molecules and their vital functions in Bombyx mori, Journal of Invertebrate Pathology, 2018, 154: 12-18.

3. Ye Pan, Peng Lü, Qinyun Wang, Feifei Zhu, Chengjun Li, Yuanqing He and Keping Chen*, Comparative transcriptomic analysis of Bombyx mori fat body tissue following dietary restriction, Archives of Insect Biochemistry and Physiology, 2017, 95(1): e21388

4. Peng Lü, Yali Xing, Zhaoyang Hu, Yanhua Yang, Ye Pan, Kangmin Chen, Feifei Zhu, Yajing Zhou, Keping Chen and Qin Yao*, A characterization of structural proteins expressed by Bombyx mori bidensovirus, Journal of Invertebrate Pathology, 2017, 144: 18-23

5. Zhichao Nie, Peng Lü*, Qiang Wang, Xu Meng, Shuang Lu, Xin Dong and Keping Chen*, Reference gene selection for quantitative real-time polymerase chain reaction analysis in Bombyx mori nucleopolyhedrovirs-infected silkworms, Invertebrate Survival Journal, 2017, 14: 94-102

6. Peng Lü, Hengchuan Xia, Lu Gao, Ye Pan, Yong Wang, Xin Cheng, Honggang Lü, Feng Lin, Liang Chen, Qin Yao, Xiaoyong Liu, Qi Tang, Keping Chen*, V-ATPase Is Involved in Silkworm Defense Response against Bombyx mori Nucleopolyhedroviurs, PLoS One, 2013, 8(6): e64962

7. Ye Pan, Peng Lü, Yong Wang, Lijing Yin, Hexiang Ma, Guohong Ma, Keping Chen, Yuanqing He*, In silico identification of novel chitinase-like proteins in the silkworm, Bombyx mori, genome, Journal of Insect Science, 2012, 12

8. Peng Lü, Keping Chen*, Qin Yao, Lu Gao, Ye Pan, Yuanqing He, Guoping Huang, Lin Wang, Expression and Localization of Bombyx mori V-ATPase 16 kDa Subunit c, Zeitschrift für Naturforschung C, 2010, 65(1-2): 119-126 (SCI)

9. Xin Dong, Peng Lü, Wu Cao, Chi Zhang, Feifei Zhu, Xu Meng, Zhichao Nie, Shuang Lu and Keping Chen*, Study of the toxicity of Bacillus cereus on silkworm (Bombyx mori) and the relevant proteome, Invertebrate Survival Journal, 2017, 14: 129-139

10. Caixia Lian, Lingling Ruan, Dongsheng Shang, Yanfang Wu, Yongjin Lu, Peng Lü, Yuhua Yang, Yajun Wei, Xiaojing Dong, Dewan Ren, Keping Chen, Hanqing Liu and Zhigang Tu*, Heparin-binding epidermal growth factor-like growth factor as potent target for breast cancer therapy, Cancer Biotherapy & Radiopharmaceuticals, 2016, 31(3): 85-90

11. Zhicai Zhang*, Lili Xia, Feng Wang, Peng Lv, Maxiaoqi Zhu, Jinhua Li and Keping Chen, Lignin degradation in corn stalk by combined method of H2O2 hydrolysis and Aspergillus oryzae CGMCC5992 liguid-state fermentation, Biotechnology for Biofuels, 2015, 8(1): online

12. Xiaoli Pan, Peng Lü, Miaomiao Zhang, Zhaoyang Hu, Guohui Li, Shangshang Ma, Fan Feng, Keping Chen, Qin Yao*, Expression Analysis of Bombyx mori Bidensovirus Structural Proteins and Assembly of Virus-like Particles in Insect Cells, Current Microbiology, 2014, 69(4): 567-573

13. Qi Tang, Guohui Li, Qin Yao, Liang Chen, Peng Lv, Chaoqun Lian, Keping Chen *, Bm91 is an envelope component of ODV but is dispensable for the propagation of Bombyx mori nucleopolyhedrovirus, Journal of Invertebrate Pathology, 2013, 113(1): 70-77

PATENTS

Peng Lü, Ye Pan, Feng Lin, Keping Chen. A single-domain antibody to HBEGF and its application. Chinese Patent application No. 201610808368.X

Keping Chen, Feng Fan, Ping Hu, Chaoqun Lian, Peng Lü, Qi Tang, Qin Yao, Yi Yuan, Chunxia Zhang and Liang Chen. A method of producing the recombinant proinsulin for oral administration. Chinese Patent No. ZL 2012 1 0571799.0