Ⅰ. General introduction of the biology discipline and the research fields

The Institute of Life Sciences was founded in March,2001. It is chaired by Shengli Yang, a renowned academician of Chinese Academy of Sciences. Although it is a new research institute in Jiangsu university, it matured quickly into an active organization with diversified research fields, including functional genomics of model organisms, transgenic technology and safety assessment, interaction of plant and microbe and its molecular regulation, animal and human molecular virology, insect bioreactor, tumor-related genes,molecular nutrition, molecular metabolism, molecular biology of enzymes,DNA damage and repair mechanisms.

The institute currently have over 40 faculties,including Dr.Keping Chen, the Dean of Institute of Life Sciences. Dr. Chen is an internationally recognized expert in the field of silkworm and virus, and is also the winner of the second award for National Science and Technology, the first and third award for Agriculture Science and Technology. Led by Dr.Chen, many research groups have been established and various studies are conducted in an independent and collaborative fashion. More than 200 papers have been published, and at least 100 publications are in SCI Journals. The ongoing studies are supported by National Science Foundation of China, Ministry of Science and Technique of China, the National Key Technologies Research and Development Program of China National Venture Foundation Development Programs, National 863 and 973 programs, the National key program of Transgenic , ministry of finance Program of China, Jiangsu High-tech Program of Jiangsu Ministry of Education. Program , Foundation of Jiangsu Talent Program and lateral research projects.

The institute has also established an excellent research platform, invested with more than 10 million RMB from central and local goverments. The institute owns Genetic Analysis system, mRNA fluorescent differential display system, Ultracentrifuge, PCR Amplifier, Nucleic acid/protein Analyzer, Cell electroporation apparatus, Hybridization Oven, Gel Documentation System, ultraflex TOF-TOF MS.

The Master Degree Program in Biology focuses on:

1.Functional genomics and proteomics of model organisms

2.Cell metabolism and molecular biology of nutrition

3.Viruses and applied microbiology

4.Cellular signal transduction and DNA damage and repair

Ⅱ. Goal & objectives

Goal of the major is to provide students with the high quality of training in diverse areas of molecular biology research that focus on the understanding of biological knowledge and facts as well as use the modern biological techniques to do biological research.

In order to achieve the goal of this major, requirements for graduate students to complete the corresponding courses within the scheduled time, also includes:

A. With correct outlook on life and values, good moral character, strict style of study, strong sense of enterprise and pioneering spirit.

B. With firm grasp of the basis theory of Biology, professional knowledge and experimental skills, professional development and frontiers; being competent of reading and writing scientific papers(In Chinese or English); with the ability to carry out scientific research work, being competent in the specialized field of teaching and research, with new insights in scientific or specialized theory or technique.

C. With physical and mental health.

D. With rigorous scientific attitude, good team spirit, strong communication ability and lifelong learning ability.

E. With strong creativity in this discipline field.

Ⅲ. Study duration and teaching methods

The master program at Institute of Life Sciences usually is a 3 year program. A master degree student can not graduate in less than 2 years or more than 4 years. The student participated in this program should finish 18 credit courses during the 1^styear, including at least 14 credits from degree courses and 4 or more credits from elective courses. Most courses are lectured in fall semester. In the remaining 2-2.5 years, the student should focus on the project research and publish a paper in a peer reviewed journal. After pass oral defense of the degree dissertation, the master degree will be awarded. Institute of Life Sciences focus on developing the student’s ability to initiate and carry out original research projects. The research programs in the institute covers the major fields of biology.

Ⅵ. Curriculum

Ⅴ. Credit requirement for practice

Biology is an experimental discipline, so students are required to do scientific experiments and learn from project research.The post-graduate students are also required to attend related seminars and experts forum, and if possible, to participate in social investigation and research or technology promotion.

1. Academic activity and seminar (³8 credits)

A postgraduate student for master degree in biology should take part in academic activity or seminar for more than 10 time, 0.5 credit each time, total 5 credit. Participation in society polling activity or technology & science promotion activity (2 credits). Post presentation or oral presentation in domestic or international conference once 1 credit. Regularly participate in lab meeting to discuss research projects weekly or bi-weekly (5 credits).

2. Reading scientific research papers and reviews (³2 credits)

A postgraduate student should read and present one or two English academic papers related to his research project every semester. And student is recommended to read more than one academic paper weekly.

3. Other practice activity (1 credit)

For those students need to do lab experiments for their research projects, the lab experiments are deemed as important practice activity. If ones research project involves no lab experiment, teaching assist or research assist to the supervisor is practice activity. A student should has at least a month experience of practice activity.

Ⅵ. Advisor committee and supervisor

The prospect postgraduate student should contact a principle investigator (PI) in this institute or a mentor in the biological mater degree program during the admission application process. An Advisory Committee initially consists of at least 3 members of the Graduate Faculty, including the Major Advisor, who acts as the chair. At least 2 members must be from Institute of Life Sciences, with at least 1 of these being a full member of the Faculty. The remaining 2 members may be from Institute of Life Sciences or another college, with 1 being a full member of the Graduate Faculty. The committee should be established by the end of the second semester of the student’s graduate career.

Ⅷ. Degree dissertation

Graduate students are required to present the research proposal in the 1^stacademic year. Once the research proposal, which is held by the institute, is agreed by the advisor committee or supervisor, the student can report the research progress in the 2^edacademic year and submit the degree dissertation 6 months later. The content of dissertation should cover his research proposal, his research project and his relevant publications in a format similar previous degree dissertation including background, methods, results, discussion and references. The details can be find in the document ‘The instruction of publication requirement for a postgraduate student to apply for degree certificate at Jiangsu University”.

VIII. Practice process and requirement

A post-graduate student should carry on original research projects to complete the degree dissertation. (The details for practice process and requirement see article V)

IX. Other issues and requirements

Graduate students are required to initiate their thesis study projects prior to the end of the second semester. The medium-term examination for thesis study is scheduled in the fourth semester. Other following important schedules relevant to your graduate study could be found from the Overseas Education College (OEC) at Jiangsu University. In general, a Master’s student is required to have a research proposal and a plan of study accepted by his or her Graduate Advisory Committee by the end of the second semester of study. A list of completed courses and those proposed to meet school requirements should also be prepared. A meeting of the Advisory Committee should be convened by the student to discuss his/her proposal and course work.

Every graduate student is required to publish at least one research paper in a recognized academic journal prior to being eligible to apply for dissertation defense. The thesis must demonstrate skill of research techniques, ability to perform original and independent research, and skill in concluding and discussion. Jiangsu University should the first institute of the aforementioned publication. Details can be found in “The principle instruction of post-graduate programs at Jiangsu university”.

X. Financial assistance

Applicants from a foreign country can apply a variety of Chinese government scholarship that may fully or partially support your degree study at JU. For further information regarding these scholarships provided by Chinese government, you can surf on the website of Overseas Education College (OEC), JU, athttp://oec.ujs.edu.cn/pub/eng/Scholarship/GS/. An average annual 5000 RMB stipend will be awarded to every student based his academic research performance by his supervisor.

ATTACHMENTS

Relevant classic books, major relevant academic journals, course content and principle investigators

I. Proposal

Graduate students are required to present the research proposal in the 1^stacademic year. A student should consult with his supervisor to determine his research project and present the proposal to his advisor committee using power point or similar tools. The proposal should cover detail research content and background of the proposed research project including rational, material, methods and strategy, preliminary result and feasibility, key creative points and problems to be solved. Student is required to answer the questions raised by member of advisor committee after the presentation. The performance will be recorded to judge the quality of the proposal.

II. Relevant classic books,

1.Alison M. Smith, Robert Sablowski, Cathie Martin, Jonathan Jones, Nick Harberd, Liam Dolan, George Coupland, Abigail Amey, Plant Biology, Press: Garland Publishing Inc, Publication Date: June 1, 2006, ISBN: 0815340257.

2.Alberts B, Johnson A, Lewis J, et al.Molecular Biology of the Cell. 4th edition.New York: Garland Science; 2002.

3.Albert et al., Molecular Biology of the Cell, Garland Publishing (can be accessed freely through PubMed Bookshelf) 2008.

4.Basic Concepts of X-Ray Diffraction, byEmil ZolotoyabkoPublication Date: April 21, 2014 | ISBN-10: 3527335617 | ISBN-13: 978-3527335619 | Edition: 1.

5.Biochemistry By Reginald H. Garret and Charles M. Grisham.

6.Biology of Aging Macieira-Coelho, Alvaro Springer-Verlag, Berlin and Heidelberg GmbH & Co. K (2002-10).

7.Brown TA.Genomes. 2nd edition.Oxford: Wiley-Liss; 2002.

8.Culture of Animal Cells: a Manual of Basic Technique.

9.Fundamentals of Molecular Virology, byNicholas H. AchesonPublication. Date: August 30, 2011| ISBN-10: 0470900598 | ISBN-13:978-0470900598| Edition: 2.

10.Gomperts, B.D.; Kramer, L.M. and Tatham, P.E.R. Signal Transduction. Academic Press 2009 .

11.Hancock, J. Cell Signalling. Oxford University Press. 3rd edition. 2010.

12.Joseph W. Lengeler, Gerhart Drews & Hans G. Schlegel.Published Online 2009 “Biology of the Prokaryotes Global Regulatory Networks and Signal Transduction Pathways (Chapter 20. Global Regulatory Networks and Signal Transduction Pathways).

13.Introduction to Proteins: Structure, Function, and Motion (Chapman & Hall/CRC Mathematical & Computational Biology), byAmit Kessel,Nir Ben-Tal, Publication Date: December 17, 2010| ISBN-10: 1439810710 | ISBN-13: 978-1439810712 | Edition: 1.

14.Nelson, J. Structure and function in cell signalling. John Wiley and Sons, 2008.

15.Modern X-Ray Analysis on Single Crystals: A Practical Guide. byPeter Luger(Author). Publisher:Walter de Gruyter & Co; 2nd Revised edition edition (March 17, 2014). ISBN-10:3110308231, ISBN-13:978-3110308235.

16.Lesk, Arthur M.Introduction to protein science : architecture, function and genomics. Oxford University Press, 2004.

17.Molecular biology of the gene, by J. D. Watson.

18.Molecular Biology: Understanding the genetic revolution (2nd edition, with annotations in Chinese), David Clark, Science Press of China, 2007.

19.Molecular Biology of the Cell (4th edition), Alberts B, Johnson A, Lewis J, et al. New York: Garland Science, 2002.

20.Molecular Biology (2nd edition), Robert F. Weaver, The McGraw-Hill Companies, 2001.

21.Molecular Biology of Cancer: Translation to the Clinic, Ruddon, Raymond, Academic Press (2010-12).

22.Molecular Cloning 3rd edition.

23.Northrop, Robert B.Introduction to molecular biology, genomics and proteomics for biomedical engineers.CRC Press/Taylor & Francis, 2009.

24.Per Lea, Richard C. Leegood, Plant Biochemistry and Molecular Biology, Press: Wiley, Publication Date: March 22 , 1999, ISBN: 0471976830.

25.Principles of Molecular Virology, Fifth Edition, byAlan J. CannPublication Date: September 16, 2011 | ISBN-10: 012384939X | ISBN-13: 978-0123849397 | Edition5.

26.Principles of X-ray Crystallography, byLi-ling OoiPublication Date: May 2, 2010 | ISBN-10: 0199569045 | ISBN-13: 978-0199569045 | Edition: (first edition).

27.Progress in Nucleic Acid Research and Molecular Biology, Conn, Dr. P. Michael, Academic Press Inc (2008-11).Proteins: Structure and Function,byDavid Whitford. Publication Date: April 29, 2005 | ISBN-10: 0471498947 | ISBN-13: 978-0471498940 | Edition: 1.

28.Regulatory Mechanisms in Transcriptional Signaling, Chakravarti, Debabrata (Debu), Academic Press Inc (2009-09).

29.Short Protocols in Protein Science.

30.Short Protocols in Molecular Biology.

31.The Double Helix by James D. Watson.

32.The Selfish Gene by Richard Dawkins.

33.Virology: Principles and Applications, byJohn Carter,Venetia Saunders, Publication Date: May 6, 2013 | ISBN-10: 1119991420 | ISBN-13: 978-1119991427 | Edition: 2.

34.Wiley-VCH Verlag GmbH & Co.KGaA,Handbook of genome research : genomics, proteomics, metabolomics, bioinformatics, ethical and legal. edited by Christoph W. Sensen. 2005.

35.Wolfram Weckwerth, Gunter Kahl, The Handbook of Plant Metabolomics, Press: Wiley-VCH Verlag GmbH, Publication Date: April 23, 2013, ISBN: 3527327770 .

36.X-Ray Crystallography,byGregory S. Girolami. Publisher:University Science Books,U.S. (August 1, 2014) ISBN-10:1891389777; ISBN-13:978-1891389771.

37.St. Clair, Caroline and Jonathan Visick. Exploring Bioinformatics: a Project-Based Approach, 2010, Jones & Bartlett.

38.Claverie, Jean-Michel and Cedric Notredame.Bioinformatics for Dummies, 2nd Edition, 2007, Wiley.

39.Westhead, D.R., J.H. Parish and R.M. Twyman. Instant Notes: Bioinformatics, 2002, BIOS Scientific Publishers Ltd.

40.Xiong, Jin. Essential Bioinformatics, 2006, Cambridge University Press.

41.Campbell, A. Malcolm and Laurie J. Heyer. Discovering Genomics, Proteomics & Bioinformatics, 2nd edition, 2007, Pearson Benjamin Cummings.

42.Baxevanis, Andreas D. and B.F. Francis Ouellette (editors). Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, 3rd edition, 2005, Wiley.

43.Gibas, Cynthia & Per Jambeck. Developing Bioinformatics Computer Skills, 2001, O’Reilly.

44.Zvelebil M J, Baum J O. Understanding bioinformatics, 2008, Garland Science.

III.Relevant academic journals

1.Algorithms for Molecular Biology

2.Annual review of Biochemisrty

3.Annual review of Genetics

4.Annual review of Genomics and Human Genetics

5.Advances in Genetics

6.American Journal of Human Genetics

7.Annals of Human Genetics

8.Biochemistry

9.Bioinformatics

10.BMC Bioinformatics

11.BMC Evolutionary Biology

12.BMC Genomics

13.BMC Genetics

13.BMC Systems Biology

14.Cell

15. Cell Signal

16. Cell Research

17.Critical reviews in Biochemistry and Molecular Biology

18.Current Oppinion in Genetics & Development

19Current Bioinformatics

20.Cancer Research,

21.Computers in Biology and Medicine

22.Computational Biology and Chemistry

23.EMBO J

24.European Journal of Human Genetics

25.Evolution

26.Evolutionary Bioinformatics

27.Genes & Development

28.Genome Biology and Evolution

29.Genome Research

30.Human Molecular Genetics

31. Human Genetics

32.International Journal of Biochemistry & Cell Biology

33.Journal of Biological Systems

34.Journal of Biological Chemistry

35.Journal of Computational Biology

36.Journal of Mathematical Biology

37. Molecular Biology and Evolution

38.MOLECULAR GENETICS AND GENOMICS

39.MOLECULAR GENETICS AND METABOLISM

40.Nature,

41.Nucleic Acids Research

42.Nature Communication

43.NATURE GENETICS

44.Nature Methods,

45.Oncogene

46.Plant Cell,

47.PLOS Computational Biology

48.PLoS Genetics

49.Proteomics

50.Proc Natl Acad Sci USA

51.Proteins-structure Function and Genetics

52.Science,

53.Systematic Biology

54.THEORETICAL AND APPLIED GENETICS

55.TRENDS IN GENETICS

The Course Syllabus for Overseas Postgraduate Students

I.Fundamental Theoretical courses

Course code：071000B1701

1. Biochemistry

Ⅰ. Scheduled total hours：32（experiments:0 hours） credits：2 term： I

Teaching method：Lecture and seminar Assessment method：Essay Report

Ⅱ.Compatible Major：Biology, Medicine, Agriculture, Pharmacology

Ⅲ.prerequisite course：Principle of biochemistry

Ⅳ.OBJECTIVE：

This course is one of fundamental part for modern biology education. The students participated this course are encouraged to understand the basics of biochemical reactions such as properties of solvents, properties of amino acids, metabolism of macro-molecules, enzyme catalyzed reaction, thermodynamics and kinetics, substrate transportation and energy metabolism. The most common techniques in biochemistry will also be covered in this course.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

1.Development of Biochemistry (6h)

Evolution of organisms and characteristic of macromolecules

Water: The Medium of Life

Development of Biochemistry and research on macromolecules

2.Structure and Function of Proteins and protein folding (6h)

Proteins: the primary structure and sequencing polypeptide

Proteins: secondary, tertiary, quaternary structure

Protein structure determination by NMR or crystallography

3. Enzyme Kinetics (6h)

Binding Analysis: for Binding Constants and Numbers of Sites

Steady State Enzyme Kinetics

Transient State (Fast) Kinetics

4.Structure and Function of Nucleic Acids (6h)

Structure and function of DNA and RNAs

Gene expression: concepts and basic procedure

Produce recombinant protein from prokaryotic and eukaryotic model organisms

5.Common biochemical techniques (8h)

PCR, RT-PCR, Real time PCR

Protein production and purification

Protein detection by western blotting, ELSA or immuno-fluorescence analysis

Protein identification by MADI-TOF-TOF mass spectrometry

Radio-ligand binding assay

Experiment：no experiment（0 h）

Ⅵ.Teaching Materials and Reference Books：

1.Biochemistry By Reginald H. Garret and Charles M. Grisham.

2.ANNUAL REVIEW OF BIOCHEMISTRY

3.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

4.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

5.Biochemistry、

6.Journal of biological chemistry

Ⅶ.Lecture(s)：Haifeng Shi, Jie Gu, Yang Zhou

Ⅷ.the Author who write the Syllabus：Haifeng Shi

Course code：071000B1702

2.Molecular Biology

Ⅰ. Scheduled total hours： 40 （experiments:0credits） credits：2term：I

Teaching method：Class teaching Assessment method：Essay Report

Ⅱ.Compatible major：Biochemistry and molecular biology

Ⅲ. Prerequisitecourses：Biochemistry, cell biology, genetics, microbiology

Ⅳ.OBJECTIVE：

The study of Molecular Biology helps students to understand biological processes at molecular level. The students are expected to learn detailed mechanisms of gene expression and regulation, DNA replication, DNA recombination and transposition in both prokaryotes and eukaryotes. They are also expected to understand the principles of major molecular biological experiments that led to acquisitions of the above knowledge.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1. Introduction(2 hours)

⑴. Overview

⑵. Molecular character of genes

3. Gene function

Chapter 2. Methods in Molecular Biology(4 hours)

⑴. Methods in Molecular cloning

⑵. Molecular tools for studying gene and gene activity

Chapter 3. Transcription in Prokaryotes(8 hours)

⑴. Transcription elements of Prokaryotes

⑵. Operons: fine control of prokaryotic transcription

⑶. Major shifts prokaryotic transcription

⑷. DNA and protein interaction in prokaryotes

Chapter 4. Gene Transcription in Eukaryotes(8 hours)

⑴. RNA polymerase and its promoter in Eukaryotes

⑵. General transcription factors in Eukaryotes

⑶. Transcriptional activators in Eukaryotes

⑷. Chromatin structure and its effects on transcription

Chapter 5. Post-transcriptional events(4 hours)

⑴. Splicing

⑵. Capping and polyadenylation

⑶. Other events

Chapter 6. Translation(4 hours)

⑴. Transcription mechanism 1: Initiation

⑵. Transcription mechanism 2: Elongation and termination

⑶. Ribosomes and transfer RNA

Chapter 7. DNA Replication, Recombination and Transposition(10 hours)

⑴. DNA replication I: Basic mechanism and enzymology

⑵. DNA replication II: Detailed mechanism

⑶. Homologous recombination

⑷. Site-specific recombination and transposition

Ⅵ.Textbooks and major reference books

⑴. Molecular Biology (2nd edition), Robert F. Weaver, The McGraw-Hill Companies, 2001.

⑵. Molecular Biology: Understanding the genetic revolution (2nd edition, with annotations in Chinese), David Clark, Science Press of China, 2007.

⑶. Molecular Biology of the Cell (4th edition), Alberts B, Johnson A, Lewis J, et al. New York: Garland Science, 2002.

Ⅶ.Teacher: Liang Chen

Ⅷ.Outline Written by Wang Yong

Course code：071000B1703

3.Molecular Oncology

Ⅰ.Scheduled total hours： 24 （experiments: 0 hours） credits： I term：

Teaching method：lecture, Assessment method：Write a report

Ⅱ.Compatible Major：Medicine, pharmacology, cell biology, molecular biology,

Ⅲ.prerequisite course：Cell biology

Ⅳ.OBJECTIVE：

Molecular Oncology course highlights new discoveries of tumorigenesis, approaches, as well as technical developments, in basic, clinical and discovery-driven translational research. This course contributes students o better understand tumorigenesis and research technology, cancer therapy.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Charpter 1. What is the tumor? Why we will get tumor?（2 hours）

Charpter 2. Tumorigenesis mechanism（4 hours）

Charpter 3. Tumorigenesis signal pathway（4 hours）

Charpter 4. Oncogene（4 hours）

Charpter 5. Tumor suppressor protein（4 hours）

Charpter 6. Protein posttranscriptional modification and tumorigenesis（4 hours）

Charpter 7Cancer therapy（2 hours）

Experiment：None1．（0 hours）

Ⅵ.Teaching Materials and Reference Books：

1．None

Ⅶ.Lecture(s)： Yongzhong Hou

Ⅷ.the Author who write the Syllabus：Yongzhong Hou

Course code：071000B1704

4.Bioinformatics

Ⅰ. Scheduled total hours：24（experiments:6hours） credits：2 term：I

Teaching method：Class teaching+Practice on computer,Assessment method：Exam (Open)

Ⅱ.Compatible Major：Biochemistry&Molecular Biology, Botany, Microbiology, Pharmacognosy, Molecular Medicine, Oncology, etc.

Ⅲ.prerequisite course：Molecular Biology, Biostatistics, Fundamentals of Computer.

Ⅳ.OBJECTIVE：

Master the basic principles and methods of bioinformatics,become knowledgeable about the principal bioinformatics databases, softwares and online tools, enable students to have the ability of biological data search, process and analysis.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1 Introduction（2 credits）

1．The definition, scope, origin and development of Bioinformatics

2．The biological basis of Bioinformatics

3．The computer basis of Bioinformatics

Chapter 2 Bioinformatics databases（4 credits h）

1．The type of Bioinformatics databases and their data formats

2．Nucleotide sequence databases (GenBank, EMBL, DDBJ, etc.)

3．Protein sequence databases (PIR, UniProt, InterPro, etc.)

4．Protein structure databases (PDB, SCOP, CATH, FSSP, etc.)

5．Other relevant databases

Chapter 3 Sequence alignment（2 credits h）

1．The basis of sequence alignment (similarity and homology, substitution, indel, etc.)

2．The methodological principles and statistical significance

3．BLAST and FASTA

4．Other relevant softwares and online tools (Clustal, Muscle, etc.)

Chapter 4 Molecular evolution analyssis（4 credits h）

1．The basic principle and concepts of molecular evolution

2．Molecular evolution models, parameters and main analysis steps

3．Phylogenetic methods (NJ, MP, ML, Bayes, etc.)

4．Relevant softwares and tools (MEGA, Phylip, PAUP, PAML, etc.)

Chapter 5 Genome analysis（2 credits h）

1．The characteristic of genome

2．Genome sequence analysis and evaluation methods

3．The gene prediction, UTR and regulatory element identification

4．Comparative genomics

Chapter 6 Protein sequence and structure analysis（4 credits h）

1．Computation and analysis of polypeptide physicochemical property

2．Protein secondary structure and classification

3．Protein structure prediction and modeling

4．Tools on proteomics analysis

Experiment：Practise using common biological databases and bioinformatics tools on computer.（6 credits h）

1． The use of common molecular biology databases including data retrieval and information extraction.

2． Molecular evolution analysis (using Clustal, MEGA, Phylip and so on)

3． The use of frequently-used bioinformatics softwars (DNAStar, Primer, AnthePro, Swiss-PDBViewer, etc.)

Ⅵ.Teaching Materials and Reference Books：

1． Mount D W. Bioinformatics: Sequence and genome analysis. New York: Cold Spring, 2004.

2． Zvelebil M J, Baum J O. Understanding bioinformatics, 2008, Garland Science.

Ⅶ.Lecture(s)：Jun Cao,Yanhua Yang

Ⅷ.the Author who write the Syllabus：Jun Cao, Yanhua Yang

II. Specialized core Courses

Course code：071000C1701

1.Instrumental Analysis and Experimental Technology in Biology

Ⅰ.Scheduled total hours：24 （experiments:18hours） credits：2 term：Ⅰ

Teaching method：Class teachingAssessment method：Other，evaluate experiment performance

Ⅱ.Compatible Major：Biology

Ⅲ.prerequisite course：None

Ⅳ.OBJECTIVE：

The purpose of the course is to help the students to understand the working principles of certain instruments, learn the operational protocol of a given instrument and the relevant experiment method.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1 Cell culture and Transgenic technology（2 credits h）

Chapter 2 Common techniques in protein detection（2 credits h）

Chapter 3 Techniques in molecular cloning (2 credits h）

Experiment：

1. DNA digestion and agarose gel electrophoresis（3 credits h）

2. Preparation and transformation of competent cells（3 credits h）

3. PCR and cloning（3 credits h）

4. Cell culture（3 credits h）

5. Immunofluorescence staining and ELISA（3 credits h）

6. Two dimensional gel electrophoresis and western-blot（3 credits h）

Ⅵ.Teaching Materials and Reference Books：

1. Molecular Cloning 3rd edition

2. Culture of Animal Cells: a Manual of Basic Technique

3. Short Protocols in Protein Science,

4. Short Protocols in Molecular Biology

Ⅶ.Lecture(s)：Peng Lv

Ⅷ.the Author who write the Syllabus：Peng Lv

III.Elective Courses

Course code：071000D1701

1.Molecular genetics

Ⅰ. Scheduled total hours：32（experiments:0 hours） credits：2 term： I

Teaching method：Lecture and seminar Assessment method：Essay Report

Ⅱ.Compatible Major：Biology, Medicine, Agriculture, Pharmacology

Ⅲ.prerequisite course：Principle of biology

Ⅳ.OBJECTIVE：

This course is one of fundamental part for modern biology education. The students participated this course are encouraged to understand the basics of the structure, and function of nucleic acids, to know the basics of DNA replication in prokaryotes and eukaryotes and the basics of transcription, translation, transcriptional control, and post-transcriptional control in prokaryotes and eukaryotes. The most common techniques in molecular genetics will also be covered in this course.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

1. Introduction: What Is a Gene? (6 h)

1. Genes and DNA. Mendelian inheritance, Non-Mendelian inheritance

2. Genes code for distinct proteins

3. Alleles, mutations, dominant and recessive genes

4. Re-evaluating the gene concept.

2. Identifying and analyzing functional genes (6 h)

5. Genetic variation & genetic mapping

6. Gene cloning strategies

7.Positional cloning

8. Transposons & gene discovery

9. Reverse genetics

3. Genomes and sequence analysis (6 h)

10. Background, bacterial genomes

11. Animal genomes; human genome

12. Human genome variation/evolution

13. Functional genomics

4. Regulation of Gene Transcription (8 h)

14. Prokaryotic transcription

15. Prokaryotic gene regulation

16. Prokaryotic gene regulation

17. Eukaryotic transcription: basal level & TFs

18. Eukaryotic transcription activation, chromatin

19. Eukaryotic transcription: Negative reg.

20. Epigenetic controls

5. Other aspects of gene regulation (6 h)

21. RNA processing, alternate splicing

22. Translational control, RNA stability

23. RNA mediated gene regulation

Ⅵ.Teaching Materials and Reference Books：

1. The Double Helix by James D. Watson and Molecular biology of the gene, by J. D. Watson.

2. The Selfish Gene by Richard Dawkins is also recommend for reading

3. NATURE GENETICS

4. ANNUAL REVIEW OF GENETICS

5. TRENDS IN GENETICS

6. HUMAN GENETICS

7. ADVANCES IN GENETICS

Ⅶ.Lecture(s)：Haifeng Shi, Jie Gu

Ⅷ.the Author who write the Syllabus：Haifeng Shi

Course code：071000D1702

2.Functional Genomics

1. Planned total class hours :32Credits. : 2 Semester:

Teaching method: classroom teaching Examination method: Report

2. Applicable major: Biochemistry and molecular biology

3. Preparatory course: Molecular biology

4. Instructional objective:

The objective is to understand the genes function in the context of the genome, analyze the transcriptome and proteome and explain the relationship between the structure and function of gene products, and the interaction of biomolecules.

5. Syllabus content and assignment

First chapter ……………Introduction（2 hours）

1．……………GenomicsIntroduction

2．……………Summary of Genomics expression

3.……………Concept and Role of Functional Genomics

Second chapter……………DNA Technology（2 hours）

1．……………Recombinant DNA technology

2.……………DNA cloning

Third chapter………Genomic mapping（3 hours）

1. ……………Genetic map

2. ……………Physical map

Fourth chapter………Genome sequence（2 hours）

1. ……………DNA sequencing method

2. ……………DNA sequences assembly

Fifth chapter………Reading Genome（3 hours）

1. ……………Gene localization

2. ……………Technology for Gene localization

3. ……………Study methods of a single gene function

Sixth chapter……………From Genome to Genome function（2 hours）

1. ……………Transcriptome and its study methods

2. ……………Proteome and its study methods

Seventh chapter……………Eukaryote nuclear genome（3 hours）

1. ……………Physical characteristics ofchromosome

2. ……………Hereditary feature of chromosome

3. ……………Functional classification of genes on nuclear genome

Eighth chapter……………Prokaryotic genome and Eukaryotic organelle genome（2 class hours）

1. ……………Physical characteristics ofProkaryotic genome

2. ……………Hereditary feature of Prokaryotic genome

3. ……………Physical characteristics of Eukaryotic organelle genome

4. ……………Hereditary feature of Eukaryotic organelle genome

Ninth chapter……………Viral genome and mobile genetic element（2 hours）

1. ……………Phage and Eukaryotic viruses genome

2. ……………Mobile genetic element

Tenth chapter……………Chromatin modification and genome expression（2 class hours）

1. ……………Chemical modification of histones

2. ……………Nucleosome remodeling

3. ……………DNA modification

4. ……………Genome expression

Eleventh chapter……………Regulation of Genome Activity（3 hours）

1. ……………Transient variation of Genome Activity

2. ……………Permanent and semi-permanent changes of Genome Activity

3. ……………Regulation of genome activity during development

Twelfth chapter……………Current progresses on functional genomics researches（6 class hours）

6. reference books

1) Alberts B, Johnson A, Lewis J, et al.Molecular Biology of the Cell. 4th edition.New York: Garland Science; 2002.

2) Brown TA.Genomes. 2nd edition.Oxford: Wiley-Liss; 2002.

3) Wiley-VCH Verlag GmbH & Co.KGaA,Handbook of genome research : genomics, proteomics, metabolomics, bioinformatics, ethical and legal.edited by Christoph W. Sensen. 2005.

4) Lesk, Arthur M.Introduction to protein science : architecture, function and genomics.Oxford University Press, 2004.

5) Northrop, Robert B.Introduction to molecular biology, genomics and proteomics for biomedical engineers.CRC Press/Taylor & Francis, 2009.

6.The teacher：Xiao-li Tan, Zheng Wang

7.Outline writer：Xiao-li Tan, Zheng Wang

Course code：071000D1703

3.Progress in Life Science

Ⅰ. Scheduled total hours：24 （experiments:0hours） credits：2 term：I

Teaching method：Class teaching and Seminar, Assessment method：Essay Report

Ⅱ.Compatible Major：Biology

Ⅲ.prerequisite course：None

Ⅳ.OBJECTIVE：

This class is specially designed to help students to understand the newest research findings inlife sciences worldwide,to know or even to predict the hotspots in research of current life sciences. This class will also cover partial history of biological researches, especially some interesting stories of the greatest biologists.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1Analysis of elite variety tag SNPs reveals an important allele in upland rice

（4 h）

Chapter 2Combinatorial temporal patterning in progenitors expands neural diversity（4 h）

Chapter 3High-resolution analysis with novel cell-surface markers identifies routes to iPS cells（4 h）

Chapter 4Obesity susceptibility loci and dietary intake in the Look AHEAD Trial

（4 h）

Chapter 5Cytolytic nanoparticles attenuate HIV-1 infectivity（4 h）

Summary and Discussion

Ⅵ.Teaching Materials and Reference Books：

1. Lyu, J., et al., Analysis of elite variety tag SNPs reveals an important allele in upland rice. Nat Commun, 2013. 4: p. 2138.

2. Bayraktar, O.A. and C.Q. Doe, Combinatorial temporal patterning in progenitors expands neural diversity. Nature, 2013. 498(7455): p. 449-55.

3. O'Malley, J., et al., High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. Nature, 2013. 499(7456): p. 88-91.

4. McCaffery, J.M., et al., Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am J Clin Nutr, 2012. 95(6): p. 1477-86.

5. Hood, J.L., et al., Cytolytic nanoparticles attenuate HIV-1 infectivity. Antivir Ther, 2013. 18(1): p. 95-103.

Ⅶ.Lecture(s)：Weijun Mai

Ⅷ.the Author who write the Syllabus：Weijun Mai

Course code：071000D1704

4.Molecular Virology

1. Total class hours：24 Credit：2 Semester：I

Teaching Methods：Classroom teaching and discussing

Examination mode：Special report

2. Adapted Major：Biochemistry and Molecular Biology，Microbiology and related major

3. Preparatory course：Virology, Molecular Biology

4. The objectives：

Let the students understand the basic theory of molecular virology through the course: to grasp the concept, classification and characteristics of the virus, as well as understand the history of Virology; to master the formation and function of virus particle; to understand the virus genome structure and its complexity, as well as the genetic and variation of virus; to grasp the virus replication cycle and its characteristics; to master the expression regulation of virus genes; to understand the virus infection and pathogenic mechanisms; to know the biological characteristics and research progress of common and emerging viruses.

5. The syllabus and time allocation：

CHAPTER 1:Introduction（2 hours）

1. What are viruses

2. The classification of viruses

3. The history of virology

CHAPTER 2: The virus particle（2 hours）

1. The formation and function of virus particle

2. Capsid symmetry and virus architecture

3. Protein-enucleic acid interactions and genome packaging

4. Virus receptors: recognition and binding

5. Other interactions of the virus capsid with the host cell

CHAPTER 3: The viral genomes（3 hours）

1.Thestructureandcomplexityofvirusgenomes

2.The characteristics of virus genomes

3. DNA viruses

4. RNA viruses

5. Segmented and multipartite virus genomes

6. Reverse transcription and transposition

7. Evolution and epidemiology

CHAPTER 4: The replication of viruses（4 hours）

1.Overview ofVirusReplication

2. The replication cycle

3. The interaction between viruses and receptors of host cell

4. The molecular mechanisms of virus invasion

5. The replication of DNA viruses

6. The replication of RNA viruses

7. The assembly, mature and release of viruses

CHAPTER 5: Control of virus gene expression（3 hours）

1. Expression of genetic information

2. Cording strategies of virus genomes

3. Transcriptionalcontrol ofexpression

4. Posttranscriptionalcontrolofexpression

5. Control ofexpressioninbacteriophageλ

CHAPTER 6: Infection（3 hours）

1. Infection of plant viruses

2.Immuneresponses tovirusinfectionsinanimals

3.Viruse-Hostinteractions

4.The Courseofvirusinfections

5.Prevention andtherapy ofvirusinfection

6.Virusvectorsandgenetherapy

CHAPTER 7: Pathogenesis of viruses（3 hours）

1.Mechanisms ofcellular Injury

2. Viruses andimmuno-deficiency

3. Virus-Relateddiseases

4. Celltransformationbyviruses

5. Viruses andcancer

6. Immune pathology of viral infection

CHAPTER 8:Molecular biology of insect viruses（2 hours）

1. Overview of insect viruses

2. Evolution and epidemiology

3. baculovirus expression vector system

4. Molecular diagnostic techniques and control methods of insect viruses

5. Genetically engineered virus insecticide

CHAPTER 9: Common and emerging virus（2 hours）

6. The referent books：

1. Principles of Molecular Virology, Fifth Edition, byAlan J. CannPublication Date: September 16, 2011 | ISBN-10: 012384939X | ISBN-13: 978-0123849397 | Edition: 5. Academic Press.

2. Virology: Principles and Applications, byJohn Carter,Venetia Saunders, Publication Date: May 6, 2013 | ISBN-10: 1119991420 | ISBN-13: 978-1119991427 | Edition: 2. Wiley Press

3. Fundamentals of Molecular Virology, byNicholas H. AchesonPublication. Date: August 30, 2011| ISBN-10: 0470900598 | ISBN-13:978-0470900598| Edition: 2. Wiley Press

4.杜平戚中田潘卫主编 《分子病毒学原理与实验技术》上海第二军医大学出版社2002

5.黄文林、姜勇、董小平、张辉 编《分子病毒学》研究生用书 人民卫生出版社2006第二版

6.李琦涵主编《病毒感染的分子生物学》化学化工出版社

7.吕鸿声著 昆虫病毒分子生物学 中国农业科技出版社1998

8.彭建新编著《杆状病毒分子生物学》2000年

Ⅶ.Lecture(s)：Zhaoyang Hu

Ⅷ.the Author who write the Syllabus：Z

Course code：071000D1705

5.Protein Structure, Function and 3-D Structure Resolution by X Ray Crystallography

Ⅰ. Scheduled total hours：24 （experiments: hours）credits：2 term：I

Teaching method：lecture+team discussion Assessment method：attendance+team report+final report

Ⅱ.Compatible Major：Biology, Medicine, Pharmaceutical majors

Ⅲ.prerequisite course：Molecular biology, Biochemistry

Ⅳ.OBJECTIVE：

This course provides postgraduates with advanced understanding about the current progresses in the filed of protein structure and function research. It covers the discussion of the basic “building blocks” of proteins and their biochemical and physical properties, and focuses on the relationship between the structure and function of proteins. It also introduces the current application of X ray Crystallography in the resolution of 3-D structures of protein and/or protein complexes. Students can advance their understanding about the close relationship of structure and function of proteins, and learn how to resolve the crystal structure of proteins. This course can help pave the way for students to carry on their studies related to proteins.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1 The primary structure of protein（4 class hours）

1．The biochemical properties of amino acid

2．The primary structure of protein and analysis method

Chapter 2 The secondary structure of protein（4 class hours）

1．The formation of secondary structure of protein

2．The analysis of secondary structure of proteins

Chapter 3 The tertiary structure of protein（4 class hours）

1．The formation oftertiary structures

2．The analysis oftertiary structures

Chapter 4 The quaternary structure of protein（4 class hours）

1．The formation ofquaternary structures

2．The analysis ofquaternary structures

Chapter 5 The structure and function of proteins（4 class hours）

1．The coordination of the structure and function of proteins

2．The current strategy and technique to study protein structure and function

Chapter 6 The crystal structure of protein（4 class hours）

1．The crystallization of proteins

2．The resolution of protein crystal structures by X ray crystallography

Ⅵ.Teaching Materials and Reference Books：

1. Proteins: Structure and Function,byDavid Whitford. Publication Date: April 29, 2005 | ISBN-10: 0471498947 | ISBN-13: 978-0471498940 | Edition: 1

2.Introduction to Proteins: Structure, Function, and Motion (Chapman & Hall/CRC Mathematical & Computational Biology), byAmit Kessel,Nir Ben-Tal, Publication Date: December 17, 2010| ISBN-10: 1439810710 | ISBN-13: 978-1439810712 | Edition: 1

3. Principles of X-ray Crystallography, byLi-ling OoiPublication Date: May 2, 2010 | ISBN-10: 0199569045 | ISBN-13: 978-0199569045 | Edition: (first edition)

4. X-Ray Crystallography,byGregory S. Girolami. Publisher:University Science Books,U.S. (August 1, 2014) ISBN-10:1891389777; ISBN-13:978-1891389771

5. Basic Concepts of X-Ray Diffraction, byEmil ZolotoyabkoPublication Date: April 21, 2014 | ISBN-10: 3527335617 | ISBN-13: 978-3527335619 | Edition: 1

6. Modern X-Ray Analysis on Single Crystals: A Practical Guide. byPeter Luger(Author). Publisher:Walter de Gruyter & Co; 2nd Revised edition edition (March 17, 2014). ISBN-10:3110308231, ISBN-13:978-3110308235

Ⅶ.Lecture(s)：Hengchuan Xia

Ⅷ.the Author who write the Syllabus：Hengchuan Xia

Course code：071000D1706

6.Cell Signal Transduction

Ⅰ. Scheduled total hours：40（experiments: 0 hour） credits：2 term： I

Teaching method：Class teaching and Seminar Assessment method：Exam(Open）and Essay Report

Ⅱ.Compatible Major：Biology,Medical inspection,Pharmacy

Ⅲ.Prerequisite course：Molecular biology,Biochemistry,Cell biology

Ⅳ.OBJECTIVE：

This course is one of the important couses for the major of biology."Signal Transduction" or "Signaling" is the process by which biological information is transferred. Signaling happens at multiple levels, from interactions between species in ecological systems to interactions between molecules inside a cell.This course aims at introducing the students to the basic components and properties of the major cell signaling pathways, with special emphasis on how they are switched on and off，and how they are regulated.

This course will helpa broad audience of students from Biological/Biomedical Sciences (including those considering medical school) interested in furthering their understanding of how cells regulate and coordinate their core activities.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1：Introduction：signaling origin and classics……………（2 credits h）

Chapter2：First messenger………… …（2creditsh）

Chapter3:Receptor……………（2creditsh）

Chapter4:GTP binding protein and signal transduction…………（1creditsh）

Chapter5:Enzymatic effectors that coupling with GTP binding protein（1creditsh）

Chapter 6:intracellular calcium and effector ………… …（2 credits h）

Chapter7:Phosphorylation and dephosphorylation:Protein kinase A and C（2 credits h）

Chapter 8：Nuclear receptor ……………（2 credits h）

Chapter9：All types ofsignal transduction pathways……………（2 credits h）

Chapter10：Specific interventions of signaling pathway fortherapeutic or research purpose……………（2 credits h）

Chapter 11：Protein domains and signal transduction ……………（2 credits h）

Ⅵ.Teaching Materials and Reference Books：

1.Albert et al.,Molecular Biology of the Cell,Garland Publishing (can be accessed freely through PubMed Bookshelf) 2008

2.Nelson, J.Structure and function in cell signalling.John Wiley and Sons, 2008

3. Hancock, J.Cell Signalling.Oxford University Press. 3rd edition. 2010

4. Gomperts, B.D.; Kramer, L.M. and Tatham, P.E.R.Signal Transduction.Academic Press 2009

Ⅶ.Lecture(s)：Jian Lu

Ⅷ.the Author who write the Syllabus：Jian Lu

Course code：071000D1707

7.Plant Molecular Biology

Ⅰ. Scheduled total hours： 24 （experiments: hours） credits：2 term：I

Teaching method：lecture and discussion Assessment method：open-book examination

II、Major: Biochemistry and Molecular Biology, Botany

III、Preparatory courses: Molecular Biology, Genetics, Plant Physiology

IV、Teaching objective:

Thiscoursebegins with a review of what is known about the origins of modern-day plants. Next, the special features of plant genomes and genetics are explored. Subsequent chapters provide information on our current understanding of plant cell biology,plantphotosynthesis and respiration,plant metabolism, and plant developmental biology, with the remaining chapters outlining the recent advances in plantproteomics and plant metabolomics.The final chapter discusses the relationship of plants with humans: domestication, agriculture and crop breeding.

In a word, this course providesundergraduate and graduate studentswith molecular biological understanding of complex biological problems aboutmodern plant science, reflecting recent advances in genetics and genomics and the excitement they have created. Meanwhile, this course can help pave the way for students to carry out their studies related to plant molecular biology.

V、Outline of the contents and time allocation：

Chapter 1 The origins of modern-day plants（2 hours）

Chapter 2 Plant genetics and functional genomics（4 hours）

1. Development and trends of plant genetics

Characteristics and trends of contemporary plant genetics

Status and role of plant genetics

The relationship between plant genetics and other disciplines of life science

Practical significance of plant genetics

2. Plant functional genomics

The historical development of plant functional genomics

The basic concept and research content of functional genome

Methods for analyzing genome function

Research status of representative plant functional genes

Chapter 3 Plant signals and signal transduction（2 hours）

1. Plant signal transduction

Signaling in plant cells

Recipient

Transmembrane signal transduction

Intracellular signaling molecule

Reversible phosphorylation of protein

2. Molecular mechanism of plant hormone signal transduction

Protein selective degradation ubiquitin/proteasome pathway

Molecular mechanism of auxin

Visfatin signal transduction

Chapter 4 Plant photosynthesis and respiration（4 hours）

1. Plant photosynthesis

The basic structure and properties of chloroplasts

Mechanism of photosynthesis

Internal and external factors affecting photosynthesis

Regulation of C3 and C4 pathway

Relationship between light energy utilization and crop biomass

2. Plant respiration

The concept, physiological significance and place of respiration

Respiratory metabolism of plants

Energy storage and utilization during respiration

Factors affecting respiration

Respiration and agricultural production

Chapter 5 Natural products chemistry (secondary metabolism)（2 hours）

1. The interaction of various organic metabolites

2. Terpenoids

3. Phenols

Chapter 6 Plant proteomics（2 hours）

1. The concept of proteome

2. The research techniques of proteomics

3. Advances in plant proteomics

4. Application and developmental trend of plant proteomics

Chapter 7 Plant metabolomics（2 hours）

1. The concept and significance of plant metabolomics

2. The role of metabonomics in system biology

3. Research methods of plant metabolomics

4. Application of metabonomics in plant science

Chapter 8 The relationship of plants with humans（2 hours）

Analysis and discussion（4hours）

VI、Teaching materials and reference books:

1. Alison M. Smith, Robert Sablowski, Cathie Martin, Jonathan Jones, Nick Harberd, Liam Dolan, George Coupland, Abigail Amey, Plant Biology, Press: Garland Publishing Inc, Publication Date: June 1, 2006, ISBN: 0815340257

2. Wolfram Weckwerth, Gunter Kahl, The Handbook of Plant Metabolomics, Press: Wiley-VCH Verlag GmbH, Publication Date: April 23, 2013, ISBN: 3527327770

3. Per Lea, Richard C. Leegood, Plant Biochemistry and Molecular Biology, Press: Wiley, Publication Date: March 22 , 1999, ISBN: 0471976830

4. Xiaoya Cheng, Hongwei Xue ed. Plant Physiology and Molecular Biology (Fourth Edition), Higher Education Press (June 1, 2012) | ISBN: 9787040351552

5. Haiyan Yan ed. Plant Developmental Molecular Biology, Science Press (First Edition) (May 1, 2012) | ISBN: 9787030340542, 703034054X

VII、Instructor：Yanhua Yang

VIII、Writer：Yanhua Yang

Course code：071000D1708

8.Global Regulatory Network and Signal Transduction in Bacteria

Ⅰ. Scheduled total hours： 32 （experiments: 0credits） credits： Ⅱ term：

Teaching method：Classroom teachingandseminars

Assessment method：Essay Report

Ⅱ.Compatible Major：Biochemistry and molecular biology，pharmacognosy

Ⅲ.prerequisite course：Biochemistry, General biology, Molecular biology, Microbiology

Ⅳ.OBJECTIVE：

This course will give an introduction to the fundamentals of the global regulatory network and signal transduction, and will cover the principles of global control of gene expression in bacteria, how these regulatory networks contribute tothe adaptation of the cell to the changed conditions and the interactions with hosts, as well as impact on virulence, secondary metabolism, motility and social behaviors etc. Progress in our understanding of and ability to manipulate these networks will have an enormous impact on a wide range of subjects ranging from microbial pathogenesis to ecology and biotechnology. In addition, the concepts and tools that emerge from experimental and theoretical work on bacterial regulatory networks are likely to be broadly applicable outside prokaryotic biology.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1 Introduction（3 h）

1. The concepts, levels and modes of control of gene expression in bacteria

2. Constitutive, inducible and suppressive gene expressions

3. Operon: the coordination unit of gene expression

4. Regulon and modulon

Chapter 2 Regulation of transcription initiation（6 h）

1. The composition of lactose operon and regulatory mechanism

● The composition of lactose operon

●Lacrepressor and the activator CAP

● The mechanism of the binding of regulatory proteins to their sites

2. The adjustment of alternative σ factors

● House-keeping gens (rpoD /s70

● Genes expressedduring periods ofstress and stationary-phase growth（rpoS/s38）

● Heat shock genes (rpoH /s32 )

● Nitrogen metabolism genes (rpoN /s54 )

● Flagellar genes(fliA /sF )

●B.subtilis(s43 )

Chapter 3 Regulation oftranscription termination: suppression andattenuation

（3 h）

1. The basic forms of transcription termination

2. The composition of tryptophan operon

3. The attenuator and its regulatory mechanism

Chapter 4 Bacterial cell-cell signaling: Quorum sensing（9 h）

1. The composition of LuxIR-type QS system

2. Types and diversity ofQS signal molecules

3.Role of QS

4.AI-2 QS regulatory system

5. Integration with other regulatory networks

6.AHL, as bacteria new signal molecules, can be used in communication between bacteria and eukaryotic hosts

Chapter 5Two-component signal transduction system（3 h）

1.The composition of GacS/GacA two-component signal transduction system

2.Signaltransductionmechanism

3.Regulation at the transcriptional and translational levels

4.Interaction with othersignaling pathways

Chapter 6 Post-transcriptional regulation mediated by RNA binding proteins and sRNAs（9 h）

1. Small non-coding RNAs (sRNAs) in Bacteria

2. Major sRNAs and theirfunctional mechanism

3.RNA chaperon Hfq and its function

4. RsmA and RsmB/C form the Rsm system

Chapter 7The intracellular second message C-di-GMP signaling（1.5 h）

Chapter 8 ppGpp and a response to poor growth environment（1.5 h）

Ⅵ.Teaching Materials and Reference Books：

1.Joseph W. Lengeler, Gerhart Drews & Hans G. Schlegel.Published Online 2009 “Biology of the Prokaryotes Global Regulatory Networks and Signal Transduction Pathways (Chapter 20. Global Regulatory Networks and Signal Transduction Pathways)

2. Biology of the prokaryotes. Lengeler et al.

3.www.nottingham.ac.uk/quorum, this web site is included in the ISI current web contents

4.http://www.mpiib-berlin.mpg.de/research/RNABiology.htm

5. http://www.unil.ch/dmf/page14869.html

Ⅶ.Lecture(s)：Xiaoguang Liu

Ⅷ.the Author who write the Syllabus：Xiaoguang Liu

Course code：071000D1709

9. Cell Biology

Ⅰ. Scheduled total hours：26（experiments:0credits） credits： 2 term：I

Teaching method：Classroom teachingandseminars

Assessment method：Essay Report

Ⅱ.Compatible Major：Biochemistry and molecular biology，Biology,

Ⅲ.prerequisite course：Biochemistry, biology, Molecular biology, Immunology

Ⅳ.OBJECTIVE：

This course will give an introduction to the fundamentals of the cell biology and the major methods, and major cell activity events such as autophagy, proliferation, apoptosis and signal transduction.Stem cell、iPS、Cancer stem cell；tumor and tumor micro-environment；tumor targeting therapy etc will be covered.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1 Development of Cell Biology and Basic Structure of Cells (2 h)

1. Content and Research Status of Cell Biology

2. Histories and Development of Cell Biology

3. Basic Cell Structure

Chapter 2 Techniques in Cell Biology (3 h)

1. Observation Methods of Cell Morphology

2. Analysis Techniques of Cell Components

3. Cell Culture and Cell Engineering

Chapter 3 Cellular Reproduction and Cell cycle Regulation (3 h)

1. The Cell Cycle and Cell Division

2. Signaling in Cell Cycle Regulation

Chapter 4 Cell Senescence, Apoptosis and Signaling (3 h)

1. Structure Differences and Molecular Mechanisms of Cellular Senescence

2. Structural Differences and Molecular Mechanisms of Apoptosis

3. Progress in Cellular Senescence and Apoptosis

Chapter 5 Autophagy, Cell Stem, iPS, Cancer Stem Cell (5 h)

1. Autophagy and Molecular Mechanism

2. Concepts and Identification of Stem cell, iPS, Cancer Stem Cell

3. Progress in Autophagy, Stem cell, iPS and Cancer Stem Cell

Chapter 6 Tumor and Tumor Microenvironment

(4 h)

1. Cell Coat and Extracellular Matrix

2. Tumor Stromal Cells and Function

3. Interaction Between Tumor Cells and Stromal Cells

Chapter 7 Tumor Targeting immunotherapy

(5 h)

1. Tumorigenesis and Treatment

2. Progress in Tumor Targeting Therapy

Chapter 8 How To Choose Thesis Topic and Design Experiment Scientifically (1 h)

1. Problems of Choosing Research Topic

2. Concise and Refinement Scientific Ideas

3. How To Design Experiment

Ⅵ.Teaching Materials and Reference Books：

1. Darnell, J.et al.Molecular Cell Biology, 5^thEdition.New York：W.H. Freeman Co. Avers, C. J..Molecular Cell Biology. Addison-Wesley Publ. Co. 2004

2. Alberts Bet al.Essential Cell Biology. 2^ndEdition. New York and London：Garland publishing，Inc. 2004

3. Gerald Karp. Cell and Molecular Biology：concepts and experiments，3^rdEdition. Published by John Wiley & Sons, Inc. 2002

Ⅶ.Lecture(s)：Feng Yu, Ai-hua Gong, Yang Zhou, Jie Gu

Ⅷ.the Author who write the Syllabus：Feng Yu

Course code：071000D1710

10. Genetic Engineering

Ⅰ. Scheduled total hours：24（experiments:0credits） credits： 2 term：I

Teaching method：Classroom teachingandseminars

Assessment method：Exam

Ⅱ.Compatible Major：Biochemistry and Molecular Biology, Biology, Medicine, Agriculture

Ⅲ.prerequisite course：Principle of Biology, Molecular Biology

Ⅳ.OBJECTIVE：

This course is one of fundamental part for modern biology education. The students participated this course are encouraged to understand the basics concept of genetic engineering, the main techniques and principle of gene engineering, polymerase chain reaction, the kinds of genetic engineering tool enzyme and gene engineering vector, the method of introduction, screening and identification of recombinant DNA, and to master the expression of foreign gene. The most common techniques in molecular biology and biochemistry will also be covered in this course.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

Chapter 1 Introduction (2 hours)

(1) The concept of genetic engineering

(2) The birth and development of genetic engineering

(3) The main content of genetic engineering research

(4) The significance and prospect of genetic engineering

(5) Biochip technology

(6) Human genome project

Chapter 2 The main techniques and principle of gene engineering (2 hours)

(1) The extraction and purification of nucleic acid

(2) Nucleic acid detection and preservation

(3) Gel electrophoresis technique

Chapter 3 Polymerase chain reaction (PCR) (2 hours)

(1) The principle of polymerase chain reaction (PCR) amplification

(2) PCR system

(3) The principle of PCR primer design

(4) The types of PCR

(5) The application of PCR technique

Chapter 4 The tool enzyme of genetic engineering (2 hours)

(1) Restriction endonuclease

(2) DNA ligase

(3) DNA polymerase

(4) Terminal deoxynucleotidyl transferase

(5) Nuclease

(6) T4 phage polynucleotide kinase

(7) Alkaline phosphatase

(8) Methylation enzyme

(9) Ribozyme

Chapter 5 The vector of gene engineering (2 hours)

(1) Plasmid vector

(2) Phage vector

(3) M13 phage vector

(4) Cosmid vector

(5) Other vectors

(6) Expression vector

Chapter 6 Introduction, screening and identification of recombinant DNA (2 hours)

(1) The method of foreign gene into prokaryotic cells

(2) The method of foreign gene into eukaryotic cells

(3)The detection of vector genetic marker

(4) The detection of cloning DNA sequence

(5) The detection of foreign gene products

Chapter 7 The expression of foreign gene (2 hours)

(1) Prokaryotic expression system

(2) Eukaryotic expression system

Ⅵ.Teaching Materials and Reference Books：

1 "Principles of Genetic Engineering" (Volume 1), editedby Wu Naihu, Science Press, 2005 Second Edition

2 "Principles of Genetic Engineering" (Volume 2), edited by Wu Naihu, Science Press, 2003 Second Edition

3 "Genetic engineering principle"edited by Xu Jinlin, Chen Chun, Xu Qin, Science Press, 2014 second edition

4 "Genetic engineering" edited by Long Minnan, Lou Shi Lin, Yang Shengchang, Zhang Jun, Science Press, 2014 third edition

5 "Genetic engineering"edited by Sun Ming, Higher Education Press, 2013 second edition

6 "Gene VIII" edited by Benjamin Lewin, translated by Yu Long, Jiang Songmin, Zhao Shouyuan etc, Science Press, 2005 first edition

7 "Molecular Cloning: A Laboratory Mannual" edited by M.R. Green, translated by He Fuchu, Science Press, 2012 fourth edition

Ⅶ.Lecture(s)：Yanhua Yang, Jun Li, Liang Chen, Qiang Wang

Ⅷ.the Author who write the Syllabus：Yanhua Yang

Course code：071000D1711

11. Scientific writing in English

Ⅰ. Scheduled total hours：24（experiments:0credits） credits： 2 term：I

Teaching method：Classroom teachingandseminars

Assessment method：Essay report

Ⅱ.Compatible Major：Biology, Biochemistry, Medicine, Pharmacy, Chemistry

Ⅲ.prerequisite course：College English

Ⅳ.OBJECTIVE：

Through the teaching of this course, the graduate students can master the access to professional literature, collect professional information, use English to summarize scientific research and experiment, use English for biology professional report exchange activities, especially to write, publish a clear logic, fluency High level SCI scientific papers and PCT patents.

Ⅴ.Content of the Syllabus and the Scheduled Study Hours:

1.SCI paper writing

1.1 Introduction (2h)

1.2 SCI research background (1h)

1.3 Research results collation, statistical analysis and chart selection (2h)

1.4 Literature retrieval, acquisition and reading (1h)

1.5 SCI papers written (4h)

1.6 SCI papers submission, repairs, proofreading and publishing (2h)

1.7 About the editorial company (1h)

1.8 Discipline (suspected) of the prevention and academic misconduct (suspect) after the remedy (1h)

1.9 Writing Skills in Chinese and English (2h)

1.10 Discussion on the SCI Division and Impact Factor (1h)

1.11 Case analysis and discussion (2h)

2. PCT patent

2.1 PCT patent review (1h)

2.2 PCT patent application process and fees (1h)

2.3 PCT patent project background (0.5h)

2.4 PCT patent claims (0.5h)

2.5 PCT patent novelty (0.5h)

2.6 PCT patent innovation (0.5h)

2.7 PCT patent implementation case (1h)

Ⅵ.Teaching Materials and Reference Books：

Main reference to online sites such as NCBI, ScienceDirect, SPRINGER LINK, Wiley Online Library, Nature, Science, Cell, PNAS, medsci.cn/, International Patent Cooperation Treaty (PCT), etc.

Ⅶ.Lecture(s)：Huayou Chen , Yajing Zhou, Yongzhong Hou, Jun Cao

Ⅷ.the Author who write the Syllabus：Yanhua Yang

V. Brief introduction of principle investigators

1. Prof.. Keping Chen, PhD ,PhD Supervisor

Education Background

2004.1-2004.7, High visiting scholars in Japan's University of Tokyo.

1997 .9 -2000 .6 PhD, Special Economic Animal Breeding , Southwestern University, P.R.China.

1979 .9-1983.6 B.Sc.,Sericulture, Anhui Agriculture University, P.R.China.

Working Experience

2001.1 – Present Professor of Institute oflife science inJiangsu University.

1983. 6 -2000 .12 Associate professor in the Research of Sericulture Institute of Chinese Academy of Agricultural Sciences.

Research Interesting

Silkworm molecular biology; Proteomics; Virus;Surface display of Exogenous gene in Bacillus subtilis.

Contacts

E-mail:kpchen@ujs.edu.cn

Tel & Fax: 0086-511-88791923

2. Prof. Haifeng Shi, PhD , PhD Supervisor

Education Background

2004-2009 Visiting fellow, Liver Diseases Branch, NIDDK, NIH.

1998-2002 Ph.D in Department of Biochemistry, The Hong Kong University of Science & Technology, Hong Kong.

1994-1998 B.Sc in Department of Biochemistry, Nanjing University, P.R. China.

Research Interesting

Biological toxicity of heavy metal such as cadmium, copper and iron;

Cellular iron metabolism; Protein engineering; Functional genetic screen.

Working Experience

2004-2009：Visiting fellow, Liver Diseases Branch, NIDDK, NIH

2001.1 – Present Professor of Institute of life science in Jiangsu University.

Contacts

Email:shihf@ujs.edu.cn

Tel: 15862996375

3. Prof.Yajing Zhou, PhD ,MS Supervisor

Education Background

2002,PhD in Biochemical Engineering, East China University of Science &.Technology, P. R. China.

1998,MS in Biochemical Engineering, East China University of Science &.Technology, P. R. China.

1982,BS in Organic Synthesis, Jiangsu Polytechnic University, P. R. China.

Working Experience

2008– Present Professor of Institute of life science in Jiangsu University.

Research Interesting

Foreign gene expression and protein production in silkworm bioreactor;

DNA replication, repair, and cell cycle regulation (Molecular mechanisms that control DNA replication and their functional regulation in mammalian cells and in model organisms).

Contacts

Email:yajingzhou@ujs.edu.cn

Websites:http://smkx.ujs.edu.cn/en/faculty/doctor/2010-10-14/31.html

4. Prof. Qin Yao, PhD Supervisor

Education Background

1979.9-1983.7 BS in Anhui Agricultural University ,P.R.China.

1990.9-1991.7 Ministry of Agriculture English training.

1996.9-1997.7 MS in Graduate School of Chinese Academy of Agricultural Science ,P.R.China.

Working Experience

2001.10-Present Professor in Insititute of Life Scicences in Jiangsu Universtiy .

1984.11-2001.9 Sericultural Research Institute of Chinese Academy of Agricultural Sciences Silkworm resources project leader.

1983.7-1984.10 Wanna College of Agriculture Agricultural Education Department teacher.

Acdamic and Social part-time: Member of Silkworm Variety Approval Committee of Jiangsu Province.

Research Interesting

Molecular biology of insect viruses.

Composition and structure of insect virus genome, the function and variation of gene;

Exploration of the new biotechnological product, e.g. recombined virus, anti-virus transgenic insect, as well as the molecular breeding technology of anti-virus silkworm.

Contacts

E-mail: yaoqin@ujs.edu.cn

Tel: 0511-88791702

Fax: 0511-88791923

5. Prof. Xiaoguang Liu, PhD ,PhD Supervisor

Education Background

2008-2009 Visiting the University of Nottingham (UK) during summer holidays.

2002-2003 Visiting Research Fellow in Hebrew University of Jerusalum, Israel.

1994 PhD in Forest Pathology, Northeast Forestry University, P. R. China.

1991 MS in Forest Pathology, Northeast Forestry University, P. R. China.

1988 Bachelar in Forest Protection, Northeast Forestry University, P. R. China.

Research Interesting

Global regulatory network and signal transduction in bacteria;

Molecular plant-microbe interactions;

Biocontrol agents of plant diseases and their mode of action;

Cross-kingdom signal transduction between bacteria and host plants.

Working Experience

2006-Present: Professor, Institute of Life sciences, Jiangsu University, China.

2002-2006: Professor, Department of Plant Pathology, Shandong Agricultural University.

2000-2001: Associated Professor, Department of Plant Pathology, Shandong Agri. Univ.

1996-2000: Associated Professor, Forest College, Agricultural University of Hebei.

1994-1996: Lecturer, Forest College of Hebei, China.

Contacts

E-mail: xgliu66@yahoo.com

Tel: 0086-511-88791702

Fax: 0086-511-88791923

6. Prof. Yongzhong Hou, PhD, MS Supervisor

Education Background

2002-2005, PhD of Cardiovascular pharmacology, Tianjin University, P.R. China.

1998-2000, MS of Biochemistry and Molecular Biology,Guizhou University, P.R. China.

1994-1998, BS of Biology,Sanxia College, P.R. China.

Research Interesting

Ubiquitin-proteasome sytem and cancer

The ubiquitin-proteasome system functions in a wide variety of cellular processes, including DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. Ubiquitination is carried out by an enzymatic cascade composed of the E1 ubiquitin-activating enzyme, the E2 ubiquitin-conjugating enzyme and the E3 ubiquitin-protein ligase. Lots of studies show that Lys-63-linked chains is associated with signal transduction, membrane-protein trafficking, endocytosis and DNA repair, in contrast, K6, K11, K27, K29, K33, K48, linked ubiquitin chains target proteins for proteasome-mediated degradation. At present, we focus three areas as follows:

1.The functional mechanism of PPARγ E3 ubiquitin ligase

2.The molecular mechanism of PPARs (PPARα, PPARγ, PPARδ) regulates tumorigenesis.

3. Synthesis and scan novel PPARs ligands to treat diseases.

Working Experience

2012-present, Professor. University of Jiangshu.

2007.11-2012.7, Postdoctoral fellow. University of Calgary, Canada.

2006.4 -2007.11, Postdoctoral fellow. Kinki University department of physiology. Japan.

2005.6-2006.2, Postdoctoral fellow. University of Florida department of medicine, USA.

Contacts

Tel: 18261977604

Email:houyz@ujs.edu.cn

7. Dr. Prof. Hongyin Zhang

Master and PhD Supervisor

Education Background

2008 Visiting Scholar in The University of Queensland, Australia,

2004 PhD of Food Microbiology, Zhejiang University, P. R. China.

2001 MS of Food Biochemistry, Henan University of Technology (Pre Zhengzhou Grain College), P. R. China.

1995 BS of Food Science and Technology, Huazhong Agricultural University, P. R. China.

Research Interesting

Food Microbiology

Biological Control of Postharvest Diseases of Fruits and Vegetables

Postharvest Physiology and Pathology of Fruits and Vegetables

Contacts

Tel.: 13812451167Fax.: 051188780201

Email: zhanghongyin@ujs.edu.cn

8. Prof. Zhigang Tu

PhD Supervisor

Education Background

2004.08-2008.10,Ph.D.in Chemical Biology & Biomedical Engineering Department, Stevens Institute of Technology, NJ, U.S.A.

2001.09-2004.06,M.S in School of Life Sciences, Nanjing University, Nanjing,P.R. China.

1997.09-2001.06,B.S .in School of Life Science and Technology, China Pharmaceutical University, Nanjing, P.R.China.

Research Interesting

1.To investigate function of BRG1 in oncogene-induced premature senescence.

2.Studied the effects of the oncogenic Ras on BRCA-1 protein and their biological consequence.

3.Designed three series of lytic peptides with high anti-cancer selectivities.

Working Experience

2013.10-Present Professor in Institute of Life Sciences, Jiangsu University.

2012.04-2013.10, Associate staff scientist in the Wistar Institute.

2008.11-2012.03, Postdoctoral fellow in Fox Chase Cancer Center.

Contacts

E-Mail:zhigangtu@ujs.edu.cn

9. Dr.Associate Prof.Yong Wang

Master Supervisor

Education Background

2008 Ph.D. in Processing & Storage of Agricultural Products, Jiangsu University, P. R. China.

1985 B.Sc in Plant Physiology, Fudan University, Shanghai, P. R. China.

Research Interesting

Identification, classification and molecular evolutionary analysis of basic helix-loop-helix transcription factors in various organisms

Contacts

E-mail: ywang@ujs.edu.cn

Phone: 86-511-13861392095

Mailing address: School of Food and Biological Engineering, Jiangsu University

No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013,P. R. China

10. Prof. Xiaoli Tan, PhD, MS Supervisor

Education Background

1998-2004, MS and PhD of Institute of Genetics and Developmental Biology Chinese Academy of Sciences ,Northwest A&F University,P. R. China.

1986-1990, B.S.of Agronomy Northwest A&F UniversityP. R. China.

Working Experience

2004-present, Institute of Life Sciences, Jiangsu University.

2009-2010, visiting scholar at Professor Ian A Graham’s lab in CNAP, Department of Biology, University of York, UK.

1990-1998, Research Assistant,Hybrid Rapeseed Research Center of Shanxi Province.

Research Interesting

Understanding the mechanism of fatty acids and lipids synthesis and regulation to promote the lipid contents in oil plant. Fatty acyl CoAs are the substrates for fatty acids and triacylglycerol (TAG), long chain fatty acyl CoA synthetase (LACS) catalyses the formation of the fatty acyl CoA. I am interested in characterization the function of LACSs in oil plant.

Plant based bioreactor development. We are developing high performance plant bioreactor to produce vaccines and assemble the multi-pathway to producepharmaceutical andindustrial important products.

Contacts

Tel.: 0086-13921587369

Email: xltan@ujs.edu.cn

11. Associate Prof. Huayou Chen, PhD, MS Supervisor

Education Background

2009.07-Present, Postdoctoral of Agricultural Engineering in Jiangsu University, P. R. China.

2003.09-2006.07, PhD ofMolecular MicrobiologyinShanghai Institutes for Biological Sciences (SIBS) of Chinese Academy of Sciences (CAS), P. R. China.

2000.09-2003.07, M.S.of Biochemistry and Molecular Biology in East China Normal University P. R. China.

Working Experience

2011.2007-Present Assistant and Associate Professor in JiangsuUniversity

2006.2007-2011.2007 Research director in Shanghai Manrun Bio. Co., Ltd.

2007.2006-2006.2007 Researcher in Shanghai celstar Bio. Co., Ltd.

2006.2003-2009.2003 Microbiology researcher in Shanghai Siji Bio. Co., Ltd.

Research Interesting

Bio-feed and genetic engineering; Enzyme engineering; Microbe metabolic engineering; Fermentation engineering; biochemical engineering.

Contacts

Tel.: +86-13912800258

Email: phdc@163.com

12. Associate Prof. Xiaoyong Liu, PhD, MS Supervisor

Education Background

2009 PhD in Insect molecular biology, Jiangsu University, P. R. China.

2001 MS in Animal physiology, Nanchang University, P. R. China.

1998 College Degree in Biology, Nanchang University, P. R. China.

Research Interesting

The interaction between insects and viruses, proteomics.

Contacts

Tel.: +86-511-88791702

Email:liuxiaoyong@ujs.edu.cn

13. Associate Prof. Guoping Huang, PhD, MS Supervisor

Education Background

2004 PhD in Zhejiang University, Hangzhou, Zhejiang, P. R. China.

2001 MS in Nanchang University, Nanchang, Jiangxi, P. R. China.

1994 Diploma in Fuzhuo Teachers Training College, Fuzhou, Jiangxi, P. R. China.

Research Interesting

Silk fibroin carrier for controlled drug release

Contacts

Tel.: +86-511-88791702

Email: Huanggp@ujs.edu.cn; hgp126126@yahoo.com.cn

14. Associate Prof. Jian Lu, PhD, MS Supervisor

Education Background

2011.2-2013.2 Postdoctoral Scholar, University of Kentucky, USA

2006.9-2009.12 PhD of Food Science, Jiangsu UniversityP R.China.

2004.9-2007.6 MS of Biochemistry and Molecular Biology, Jiangsu University,P R.China.

1997.9-2001.6 BS in Biopharmaceutical Engineering, Nanjing University & China Pharmaceutical University, P.R.China.

Working Experience

2012- Present Research Associate , Institute of Life Sciences, Jiangsu University

2011.2-2013.2 Reaseach assistant,University of Kentucky,USA

2006- 2012 Assistant professor, Institute of Life Sciences, Jiangsu University

2001-2006 Teaching assistant, Institute of Life Sciences, JiangsuUniversity

2006-2012 assistant professor, Institute of Life Sciences, JiangsuUniversity

Research Interesting

Reveal the effects of environmental toxin on physiology, biochemistry, metabolism, development and genetics of human and animals and related biological mechanisms;

Prevention of cancers induced by environmental toxin, including heavy metals and all kinds of chemicals;

Anticancer mechanism of natural compounds from dietary foods or traditional Chinese medicine.

Contacts

Tel:086-511-85878748

Email:lujian@ujs.edu.cn

15. Associate Prof. Zhongjian Guo, PhD, MS Supervisor

Education Background

2011 Postdoc, Louisiana State University, USA.

2005 PhD in Agricultural Insect and Pest Management, Zhejiang University, Hangzhou, P.R.China.

2002 MS in Agricultural Insect and Pest Management, Henan University of Technology, Zhengzhou, P.R.China.

1999 College Degree in Agricultural Insect and Pest Management, Henan University of Technology, Zhengzhou, P.R.China.

Working experience

2005-Present Institute of Life Sciences, Jiangsu University, P.R. China.

2011-2012 School of Veterinary Medicine, Louisiana State University, USA.

Research Interesting

Heat shock response of silkworm to infection ofBombyx morinucleopolyhedrovirus;

Role of silkworm ubiquitin-proteosome system on propagation ofBombyx mori;nucleopolyhedrovirus.

Contacts

Tel.: +86-13951287662

Email:gzh762677@ujs.edu.cn

16. Associate Prof. Qinggang Xu, PhD, MS Supervisor

Education Background

2006-2009 PhD of Genetics, Zhejiang University, P.R.China.

1999-2002 MS of Entomology, Northwest A&F University,P.R.China.

1991-1995 BS of Plant Protection, Northwest Agricultural University, P.R.China.

Research Interesting

Cellulose hydrolytic enzymes in wood-feeding termites and microorganisms;

Intestinal symbiotic microorganisms of insects and their applications.

Contacts

E-mail: xuqg@ujs.edu.cn

Tel: +86-511-88791702

17. Research Assistant Weijun Mai, PhD, MS Supervisor

Education Background

2005 PhD, South China Sea Institute of Oceanology, CAS.

2001 MS, South China Institute of Botany,P.R.China.

1997 BS, Guangzhou University,P.R.China.

Working experience

2010-Present Research Assistant in Institute of Life Sciences, Jiangsu University.

2008-2010 Postdoctor, School Of Life Science, South China Normal University.

Research Interesting

Molecular immunity of the commercial marine species;

Functional studies on immune genes of aquatic animal;

Cell damage and repair and their functional regulation in mammalian cells and model organisms.

Contacts

E-mail:mwj9876@yahoo.com.cn

Tel: 86-511-88791702

18. Associate Prof. Li Gao, PhD, MS Supervisor

Education Background

2010 PhD of Biomedical Engineering, Southeast University, Nanjing,P.R.China.

2004 MS of Plant Genetic Breeding, Anhui Agricultural Universtiy,Hefei, P.R.China.

2001 BS of Biology, Jiangsu Normal Univeristy, Xuzhou, P.R.China.

Research Interesting

DNA sequencing on a microarray;

Label-free detection based on biosensor.

Contacts

Email: gaoli@ujs.edu.cn

Tel.: +86-511-88791702

19. Research Assistant Guohui Li, PhD, MS Supervisor

Education Background

2008 PhD in SUN YAT-SEN University, Guangzhou, Guangdong, P. R. China.

2005 MS in JiNan University, Guangzhou, Guangdong, P. R. China,

1997 Diploma in GuangZhou University, Guangzhou, Guangdong, P. R. China.

Research Interesting

Molecular mechanism of interaction between insect virus and host;

Gene expression regulation.

Contacts

E-mailliguohuijnl@yahoo.com.cn

Tel: 0511-88791702, 15052931327

20. Research Assistant Zheng Wang,PhD,MS Supervisor

Education Background

2009 PhD of Biochemistry and Molecular Biology, The Chinese Academy of Agricultural Sciences ,P. R. China.

2005 MS of College of Agriculture, Inner Mongolia Agricultural University, P. R. China.

Research Interesting

The interaction between plant and pathogen;

Plant Functional Genomics.

Contacts

E-mailWangzheng4466@163.com

Tel: 0511-88791702

21. Research Assistant Huiqing Chen, PhD, MS Supervisor

Education Background

2008 PhD in Life science, Jiangsu University, P. R. China.

2005 MS in Life science, Zhongshan University, P. R. China

1998 College Degree in Life science, South China Normal University, P. R. China.

Working experience

2008-Present Research Assistant in Institute of Life Sciences, Jiangsu University.

Contacts

Email: sw98318@21cn.com

Tel.: +86-511-88791923

22. Research Assistant. Keming Zhu, PhD, MS Supervisor

Education Background

2009 PhD inYangzhou University, Yangzhou, P.R. China.

2006 MS in Yangzhou University, Yangzhou, P.R. China.

2003,BS in Yangzhou University, Yangzhou, P.R. China.

Research Interesting

The cloning and functional analysis of important genes in Rice.

Contacts

E-mail: uegzkg@ujs.edu.cn

23. Research Assistant Jun Cao, PhD, MS Supervisor

Education Background

2009 PhD of Genetics, College of Life Science, Zhejiang University, P. R. China, .

2003 MS of Biochemistry and Molecular Biology, College of Life Science, ShandongAgricultural University, P. R. China,.

2000 Bachelor’s Degree in Silkworm, College of Forestry, Shandong Agricultural University, P. R. China.

Research Interesting

DNA specific genetic structure, evolution and function;

Molecular genetics and compensatory evolution;

Gene expression regulation.

Contacts

Tel.: +86-511-88791702

Email:cjinfor@163.com

24. Research Assistant Zhaoyang Hu, PhD, MS Supervisor

Education Background

2009-2010 State Key Laboratory of Bioconctrol, Sun Yat-Sen University.

2005-2009 PhD in School of Life Science, Sun Yat-Sen University.

2002-2005 MS in School of Life Science and Technology, Guangxi university,P.R.China.

Working experience

2010-present,Research Assistant in Institute of Life Sciences, Jiangsu University.

Research Interesting

Molecular biology of insect virus;

Study the interaction between the insect viruses and its hosts.

Contacts

Email:sunnyhu163@163.com

Tel.: +86-511-88791702

25. Associate Professor, Hengchuan Xia, PhD, MS Supervisor

Education Background

1993-1997, Qu Fu Normal University, General Biology, B.Sc.

1997-2004, Shanghai Institute of Biochemistry and Cellular Biology, Chinese Academy of Science, Biochemistry and Molecular Biology, Ph.D.

Working experience

2004-2008, University of Michigan, U.S., Structural Biology, Cellular Biology, Visiting Scholar

2008-present,Life Sciences Institute, Jiangsu University, China

Research Interesting

Molecular biology of Insects, Interactions between insect viruses and hosts, Structural and functional studies of proteins.

Contacts

Email: hchxia@mail.ujs.edu.cn

Tel.: +86-511-88791702

26. Research Assistant Qiang Wang, PhD, MS Supervisor

Education Background

2005-2008, Jiangsu University, B.Sc.

2008-2013, Kazawa University, Japan, Ph.D.

Working experience

2008-Present Research Assistant in Institute of Life Sciences, Jiangsu University.

Contacts

Email: wangqiang@ujs.edu.cn

Tel.: +86-511-88791923

27. Associate Prof. Yang Zhou, PhD, MS Supervisor

Education Background

2010 PhD in Life science, Jiangsu University, P. R. China

2004 MS of Plant Genetic Breeding, Anhui Agricultural Universtiy, Hefei, P.R.China.

2001 BS of Biology, Nanjing Normal Univeristy, Nanjing, P.R.China.

Working experience

2010-Present Research Assistant in Institute of Life Sciences, Jiangsu University

Research Interesting

1. Molecular mechanism of interaction between insect virus and host

2. Biological toxicity of heavy metal such as iron, copper and cadmium

Contacts

Email: zhouyang@ujs.edu.cn

Tel.: +86-511-88791702

28.Associate Prof.GU Jie MS Supervisor NAME .

Gender: Male Degree: Doctor

Education Background

2011/07-2014/06, Hong Kong Baptist University, Biology, Doctor

2009/03-2011/02, Hong Kong Baptist University, Biology, Master

2005/09-2008/06, Yangzhou University, Biochemistry and Molecular Biology, Master

2001/09-2005/06, Yangzhou University, Biological Science and Technology, Bachelor

Working Experience

2017/09 - Present, Jiangsu University, Institute of life Sciences, associate professor

2015/06-2016/08, Jiangsu University, Institute of life Sciences, assistant professor

2014/07-2015/06, Hong Kong Baptist University, Department of Biology, Senior Research assistant

Research Interesting

Molecular toxicology mechanism of heavy metals

Calcium homeostasis related diseases

Environmental pollution associated clinical diseases

Contacts

Email: 1000004531@ujs.edu.cn Tell: 13405583078,

29. Assistant Lipeng Qiu, Ph.D., MS Supervisor

Education Background

2007.09-2011.07, Ph.D. in Biochemistry and molecular biology, Key Laboratory of Pathogenic Microbiology and Immunology (PMI), Institute of Microbiology, Chinese Academy of Sciences (IMCAS), China

2001.09-2004.07, M.S. in Microbial and Biochemical Pharmacy, Shenyang Pharmaceutical University (SPU), China

1997.09-2001.07, B.Eng. in Microbial pharmaceutics, SPU, China

Working Experience

2013.12-2016.09 Postdoctoral fellow at Johns Hopkins University School of Medicine, U.S.A.

2011.09-2016.06 Postdoctoral fellow at Jiangsu University, China

2011.07-Present Research Assistant at Jiangsu University, China

2004.07-2007.07 Assistant Lecturer at Changzhou University, China

Research Interests

The function and regulatory mechanism of non-coding RNA in different diseases; hepatitis B; allergic asthma

Contacts

Tel.: +86-511-88791702

E-mail address: qiulp@mail.ujs.edu.cn

30. Assistant Prof. Qi Tang, PhD, MS Supervisor

Education Background

2013 PhD in Life science, Jiangsu University, P. R. China.

2005 MS in JiNan University, Guangzhou, Guangdong, P. R. China.

2002 College Degree in Life science, South China Normal University, P. R. China.

Working experience

2013-present,Research Assistant in Institute of Life Sciences, Jiangsu University.

Research Interesting

Molecular biology of insect virus;

Study the interaction between the insect viruses and its hosts.

Contacts

Email:tangqi1224@163.com

Tel.: +86-511-88791702

31. Associate Prof. Qian Yu, PhD, MS Supervisor

Education Background

2010-2015. PhD in INRS-Institut Armand-Frappier, University of Quebec,Laval, Quebec, Virology and Immunology

2007-2010. M.S. in Central China Normal University, Wuhan, China, Microbiology,

2002-2006. B.Sc in Central China Normal University, Wuhan, China Biotechnology,

Research Interesting

Genome organization and transcription strategies of insect viruses

Evolution of insect viruses

Discovery of new viruses

Contacts

E-mail: qianyu@ujs.edu.cn

Tel: (+86)15050853270

32. Research Assistant Feng Yu, PhD, MS Supervisor

Education Background

2012-2015 Postdoc, Baylor college of Medicine, USA.

2010 PhD in Life science, Jiangsu University, P. R. China.

2003 MS in College of Veterinary Medicine, Yangzhou University, P. R. China

2000 Bachelor’s Degree in Huazhong Agricultural University, P. R. China.

Working experience

2003-Present Research Assistant in Institute of Life Sciences, Jiangsu University

Research Interesting

Cancer immunotherapy: Oncolytic virus therapy and CAR-T cell

33. Assistant Prof. Lina Ding, PhD, MS Supervisor

Education Background

2011 PhD in Nanjing Agricultural University, P. R. China.

2006 MS in Nanjing Agricultural University, P. R. China

2004 Bachelor’s Degree in Shandong Agricultural University, P. R. China.

Working experience

2011-Present Assistant Prof. in Institute of Life Sciences, Jiangsu University.

Research Interesting

The mechanism of plant-pathogen interactions

Signal transduction pathway and proteomics

Contacts

Email: lnding6@126.com

Tel.: +86-511-88791923

34. Peng Lü, Ms Supervisor

Education Background

2011.09-2014.06 PhD in Jiangsu University, P. R. China.

2006.09-2009.06 Ms in Jiangsu University, P. R. China

2002.09-2006.06 Bachelor in Jiangsu University, P. R. China.

Working Experience

2014.12-Present Assistant Professor in Insititute of Life Scicences, Jiangsu Universtiy .

2010.12-2011.08 Marketing Specialist in Seajet Scientific Ltd.

2009.06-2010.12 Research Asistant in Institut Pasteur of Shanghai Chinese Academy of Sciences

Research Interesting

Interaction between insect viruses and their host;

Panning and application of humanized engineered antibody

Contacts

E-mail: penglu@ujs.edu.cn

Tel: 0511-88791702

Fax: 0511-88791923

35. Associate professor Yanhua Yang, PhD, Master Supervisor

Education Background

2004.9-2008.7 Ph.D. in molecular biology and moleculalr evolution

(Supervisor: Prof. Song Ge) State Key Laboratory of Systematic and Evolutionary Botany, Institute ofBotany, Chinese Academy of Sciences, Beijing, China

2000.9-2003.6 M.S. in botany

(Supervisor: Prof. Guoxiang Chen) Institute of Life Sciences, Nanjing Normal University, Nanjing, China

Working Experience

2014/7-Present Associate Professor, Institute of Life Sciences, Jiangsu University

2010/7-2014/7 Assistant Professor, Institute of Life Sciences, Jiangsu University

2008/8-2010/7 Assistant Professor, Institute of Food Crops, Jiangsu Academy of Agricultural Sciences

Research interests

Functional genomics and proteomics of model organism, Molecular systematics and molecular evolution

Contacts

Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, China

Tel:86-(0)15262918732

Email:yanhuayang@126.com

36. Associate Prof. Feifei Zhu, PhD, MS Supervisor

Education Background

2009-2014. PhD in Analytical Chemistry, Department of Chemistry, Indiana University, USA

2005-2009. B.Sc in School of Chemistry and Chemical Engineering, Nanjing University, China

Research Interesting

Glycomic, proteomic, and glycoproteomic analysis and functional studies using different animal models

Contacts

E-mail: feifzhu@ujs.edu.cn

Tel: (+86)18705296369